Effect of left atrial and ventricular abnormalities on renal transplant recipient outcome—a single-center study

Background: Premature cardiovascular (CV) death is the commonest cause of death in renal transplant recipients. Abnormalities of left ventricular (LV) structure (collectively termed uremic cardiomyopathy) and left atrial (LA) dilation, a marker of fluid status and diastolic function, are risk factors for reduced survival in patients with end stage renal disease (ESRD). In the present analysis, we studied the impact of pre-transplant LA and LV abnormalities on survival after successful renal transplantation (RT).<p></p> Methods: One hundred nineteen renal transplant recipients (first transplant, deceased donors) underwent cardiovascular MRI (CMR) as part of CV screening prior to inclusion on the waiting list. Data regarding transplant function and patient survival after transplantation were collected.<p></p> Results: Median post-transplant follow-up was 4.3 years (interquartile range (IQR) 1.9, 6.2). During the post-transplant period, 13 patients returned to dialysis after graft failure and 23 patients died with a functioning graft. Survival analyses, censoring for patients returning to dialysis, showed that pre-transplant LV hypertrophy and elevated LA volume were significantly associated with reduced survival after transplantation. Multivariate Cox regression analyses demonstrated that longer waiting time, poorer transplant function, presence of LV hypertrophy and higher LA volume on screening CMR and female sex were independent predictors of death in patients with a functioning transplant.<p></p> Conclusions: Presence of LVH and higher LA volume are significant, independent predictors of death in patients who are wait-listed and proceed with renal transplantation.<p></p> METHODS: One hundred nineteen renal transplant recipients (first transplant, deceased donors) underwent cardiovascular MRI (CMR) as part of CV screening prior to inclusion on the waiting list. Data regarding transplant function and patient survival after transplantation were collected.<p></p> RESULTS: Median post-transplant follow-up was 4.3 years (interquartile range (IQR) 1.9, 6.2). During the post-transplant period, 13 patients returned to dialysis after graft failure and 23 patients died with a functioning graft. Survival analyses, censoring for patients returning to dialysis, showed that pre-transplant LV hypertrophy and elevated LA volume were significantly associated with reduced survival after transplantation. Multivariate Cox regression analyses demonstrated that longer waiting time, poorer transplant function, presence of LV hypertrophy and higher LA volume on screening CMR and female sex were independent predictors of death in patients with a functioning transplant.<p></p> CONCLUSIONS: Presence of LVH and higher LA volume are significant, independent predictors of death in patients who are wait-listed and proceed with renal transplantation

Sensitivity-analysis method for inverse simulation application

An important criticism of traditional methods of inverse simulation that are based on the Newton–Raphson algorithm is that they suffer from numerical problems. In this paper these problems are discussed and a new method based on sensitivity-analysis theory is developed and evaluated. The Jacobian matrix may be calculated by solving a sensitivity equation and this has advantages over the approximation methods that are usually applied when the derivatives of output variables with respect to inputs cannot be found analytically. The methodology also overcomes problems of input-output redundancy that arise in the traditional approaches to inverse simulation. The sensitivity- analysis approach makes full use of information within the time interval over which key quantities are compared, such as the difference between calculated values and the given ideal maneuver after each integration step. Applications to nonlinear HS125 aircraft and Lynx helicopter models show that, for this sensitivity-analysis method, more stable and accurate results are obtained than from use of the traditional Newton–Raphson approach

No classical limit of quantum decay for broad states

Though the classical treatment of spontaneous decay leads to an exponential decay law, it is well known that this is an approximation of the quantum mechanical result which is a non-exponential at very small and large times for narrow states. The non exponential nature at large times is however hard to establish from experiments. A method to recover the time evolution of unstable states from a parametrization of the amplitude fitted to data is presented. We apply the method to a realistic example of a very broad state, the sigma meson and reveal that an exponential decay is not a valid approximation at any time for this state. This example derived from experiment, shows the unique nature of broad resonances

Folding model analysis of alpha radioactivity

Radioactive decay of nuclei via emission of $\alpha$ particles has been studied theoretically in the framework of a superasymmetric fission model using the double folding (DF) procedure for obtaining the $\alpha$-nucleus interaction potential. The DF nuclear potential has been obtained by folding in the density distribution functions of the $\alpha$ nucleus and the daughter nucleus with a realistic effective interaction. The M3Y effective interaction has been used for calculating the nuclear interaction potential which has been supplemented by a zero-range pseudo-potential for exchange along with the density dependence. The nuclear microscopic $\alpha$-nucleus potential thus obtained has been used along with the Coulomb interaction potential to calculate the action integral within the WKB approximation. This subsequently yields microscopic calculations for the half lives of $\alpha$ decays of nuclei. The density dependence and the exchange effects have not been found to be very significant. These calculations provide reasonable estimates for the lifetimes of $\alpha$ radioactivity of nuclei.Comment: 7 pages including 1 figur

Uncertainty in the evolution of northwestern North Atlantic circulation leads to diverging biogeochemical projections

The global ocean's coastal areas are rapidly experiencing the effects of climate change. These regions are highly dynamic, with relatively small-scale circulation features like shelf break currents playing an important role. Projections can produce widely diverging estimates of future regional circulation structures. Here, we use the northwestern North Atlantic, a hotspot of ocean warming, as a case study to illustrate how the uncertainty in future estimates of regional circulation manifests itself and affects projections of shelf-wide biogeochemistry. Two diverging climate model projections are considered and downscaled using a high-resolution regional model with intermediate biogeochemical complexity. The two resulting future scenarios exhibit qualitatively different circulation structures by 2075 where along-shelf volume transport is reduced by 70 % in one of them and while remaining largely unchanged in the other. The reduction in along-shelf transport creates localized areas with either amplified warming (+3 ∘C) and salinification (+0.25 units) or increased acidification (−0.25 units) in shelf bottom waters. Our results suggest that a wide range of outcomes is possible for continental margins and suggest a need for accurate projections of small-scale circulation features like shelf break currents in order to improve the reliability of biogeochemical projections.</p

Geometry and Structural Modeling for High-Fidelity Aircraft Conceptual Design Optimization

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140431/1/6.2014-2041.pd

Radioactive decays at limits of nuclear stability

The last decades brought an impressive progress in synthesizing and studying properties of nuclides located very far from the beta stability line. Among the most fundamental properties of such exotic nuclides, usually established first, is the half-life, possible radioactive decay modes, and their relative probabilities. When approaching limits of nuclear stability, new decay modes set in. First, beta decays become accompanied by emission of nucleons from highly excited states of daughter nuclei. Second, when the nucleon separation energy becomes negative, nucleons start to be emitted from the ground state. Here, we present a review of the decay modes occurring close to the limits of stability. The experimental methods used to produce, identify and detect new species and their radiation are discussed. The current theoretical understanding of these decay processes is overviewed. The theoretical description of the most recently discovered and most complex radioactive process - the two-proton radioactivity - is discussed in more detail.Comment: Review, 68 pages, 39 figure

Hidden evidence of non-exponential nuclear decay

The framework to describe natural phenomena at their basics being quantum mechanics, there exist a large number of common global phenomena occurring in different branches of natural sciences. One such global phenomenon is spontaneous quantum decay. However, its long time behaviour is experimentally poorly known. Here we show, that by combining two genuine quantum mechanical results, it is possible to infer on this large time behaviour, directly from data. Specifically, we find evidence for non-exponential behaviour of alpha decay of 8Be at large times from experiments.Comment: 12 pages LaTex, 3 figure

Physical Qualities of International Female Rugby League Players by Playing Position.

The purpose of the current study was to investigate the anthropometric, body composition and fitness characteristics of female rugby league players by playing position. Data were collected on 27 players who were part of the English elite women's rugby league squad. Player assessments comprised anthropometric (stature and body mass), body composition (dual-energy X-ray absorptiometry) and fitness (lower-body power [countermovement jump (CMJ), 20 kg jump squat (JS) and 30 cm drop jump], 5, 10, 20, 30, and 40 m sprint, 505 agility, Yo-Yo intermittent recovery test level 1) measures. Players were classified into playing position (i.e., forwards and backs) prior to analysis. A multivariate analysis of variance (MANOVA) demonstrated significant (p<0.05) differences for body mass, stature, total fat, lean mass and percentage body fat between forwards and backs. Positional differences were also observed for speed, agility and lower-body power. Significant relationships were observed between total body fat and all fitness variables, and total lean mass was related to CMJ and JS peak power. This study provides comparative data for female rugby league forwards and backs. Body fat was strongly associated with performance and should therefore be considered in developing fitness characteristics. The relationship to match performance and trainability of these characteristics warrants further investigation

Theoretical Study of Fluid Membranes of Spherical Topology with Internal Degrees of Freedom

A theoretical study of vesicles of topological genus zero is presented. The bilayer membranes forming the vesicles have various degrees of intrinsic (tangent-plane) orientational order, ranging from smectic to hexatic, frustrated by curvature and topology. The field-theoretical model for these `$n$-atic' surfaces has been studied before in the low temperature (mean-field) limit. Work presented here includes the effects of thermal fluctuations. Using the lowest Landau level approximation, the coupling between order and shape is cast in a simple form, facilitating insights into the behaviour of vesicles. The order parameter contains vortices, whose effective interaction potential is found, and renormalized by membrane fluctuations. The shape of the phase space has a counter-intuitive influence on this potential. A criterion is established whereby a vesicle of finite rigidity may be burst by its own in-plane order, and an analogy is drawn with flux exclusion from a type-I superconductor.Comment: 34 pages + 4 Postscript figures. Uses RevTe