On the Impact of Multiobjective Scalarizing Functions

Recently, there has been a renewed interest in decomposition-based approaches for evolutionary multiobjective optimization. However, the impact of the choice of the underlying scalarizing function(s) is still far from being well understood. In this paper, we investigate the behavior of different scalarizing functions and their parameters. We thereby abstract firstly from any specific algorithm and only consider the difficulty of the single scalarized problems in terms of the search ability of a (1+lambda)-EA on biobjective NK-landscapes. Secondly, combining the outcomes of independent single-objective runs allows for more general statements on set-based performance measures. Finally, we investigate the correlation between the opening angle of the scalarizing function's underlying contour lines and the position of the final solution in the objective space. Our analysis is of fundamental nature and sheds more light on the key characteristics of multiobjective scalarizing functions.Comment: appears in Parallel Problem Solving from Nature - PPSN XIII, Ljubljana : Slovenia (2014

A multi-objective approach to solve the build orientation problem in additive manufacturing

Additive manufacturing (AM) has been increasingly used in the creation of three-dimensional objects, layer-by-layer, from three-dimensional (3D) computer-aided design (CAD) models. The problem of determining the 3D model printing orientation can lead to reduced amount of supporting material, build time, costs associated with the deposited material, labor costs, and other factors. This problem has been formulated and studied as a single-objective optimization problem. More recently, due to the existence and relevance of considering multiple criteria, multi-objective approaches have been developed. In this paper, a multi-objective optimization approach is proposed to solve the part build orientation problem taking into account the support area characteristics and the build time. Therefore, the weighted Tchebycheff scalarization method embedded in the Electromagnetism-like Algorithm will be used to solve the part build orientation bi-objective problem of four 3D CAD models. The preliminary results seem promising when analyzing the Pareto fronts obtained for the 3D CAD models considered. Concluding, the multi-objective approach effectively solved the build orientation problem in AM, finding several compromise solutions.This work has been supported and developed under the FIBR3D project - Hybrid processes based on additive manufacturing of composites with long or short fibers reinforced thermoplastic matrix (POCI-01-0145-FEDER-016414), supported by the Lisbon Regional Operational Programme 2020, under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF). This work was also supported by FCT - Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019

Potent high-avidity neutralizing antibodies and T cell responses after COVID-19 vaccination in individuals with B cell lymphoma and multiple myeloma.

Individuals with hematologic malignancies are at increased risk for severe coronavirus disease 2019 (COVID-19), yet profound analyses of COVID-19 vaccine-induced immunity are scarce. Here we present an observational study with expanded methodological analysis of a longitudinal, primarily BNT162b2 mRNA-vaccinated cohort of 60 infection-naive individuals with B cell lymphomas and multiple myeloma. We show that many of these individuals, despite markedly lower anti-spike IgG titers, rapidly develop potent infection neutralization capacities against several severe acute respiratory syndrome coronavirus 2 variants of concern (VoCs). The observed increased neutralization capacity per anti-spike antibody unit was paralleled by an early step increase in antibody avidity between the second and third vaccination. All individuals with hematologic malignancies, including those depleted of B cells and individuals with multiple myeloma, exhibited a robust T cell response to peptides derived from the spike protein of VoCs Delta and Omicron (BA.1). Consistently, breakthrough infections were mainly of mild to moderate severity. We conclude that COVID-19 vaccination can induce broad antiviral immunity including ultrapotent neutralizing antibodies with high avidity in different hematologic malignancies