Mesoscopic Mechanical Resonators as Quantum Non-Inertial Reference Frames

An atom attached to a micrometer-scale wire that is vibrating at a frequency of 100 MHz and with displacement amplitude 1 nm experiences an acceleration magnitude 10^9 ms^-2, approaching the surface gravity of a neutron star. As one application of such extreme non-inertial forces in a mesoscopic setting, we consider a model two-path atom interferometer with one path consisting of the 100 MHz vibrating wire atom guide. The vibrating wire guide serves as a non-inertial reference frame and induces an in principle measurable phase shift in the wave function of an atom traversing the wire frame. We furthermore consider the effect on the two-path atom wave interference when the vibrating wire is modeled as a quantum object, hence functioning as a quantum non-inertial reference frame. We outline a possible realization of the vibrating wire, atom interferometer using a superfluid helium quantum interference setup.Comment: Published versio

Measurement of energy eigenstates by a slow detector

We propose a method for a weak continuous measurement of the energy eigenstates of a fast quantum system by means of a "slow" detector. Such a detector is only sensitive to slowly-changing variables, e. g. energy, while its back-action can be limited solely to decoherence of the eigenstate superpositions. We apply this scheme to the problem of detection of quantum jumps between energy eigenstates in a harmonic oscillator.Comment: 4 page

Quantum measurement backaction from a BEC coupled to a mechanical oscillator

We study theoretically the dynamics of a a hybrid optomechanical system consisting of a macroscopic mechanical membrane magnetically coupled to a spinor Bose-Einstein condensate via a nanomagnet attached at the membrane center. We demonstrate that this coupling permits us to monitor indirectly the center-of-mass position of the membrane via measurements of the spin of the condensed atoms. These measurements normally induce a significant backaction on the membrane motion, which we quantify for the cases of thermal and coherent initial states of the membrane. We discuss the possibility of measuring that quantum backaction via repeated measurements. We also investigate the potential to generate non-classical states of the membrane, in particular Schrodinger cat states, via such repeated measurements.Comment: 14 pages, 4 figures. Submitted to PR

Schwann cells migrate along axons in the absence of GDNF signaling

BACKGROUND: During development neural crest derived Schwann Cell (SC) precursors migrate to nerve trunks and populate nascent nerves. Axonal ensheathment by SC is a prerequisite for normal nerve function and the integrity of myelinated as well as nonmyelinated axons. To provide adequate support functions, SC colonize entire nerves. One important prerequisite for this is their migration into distal axonal regions. RESULTS: Here, we studied the role of Glial cell line derived neurotrophic factor (GDNF), a TGF-beta related growth factor, for SC migration. To this end we used a superior cervical ganglion (SCG) explant-SC migration assay, GDNF null mutant mouse embryos and a chemical inhibitor for GDNF signaling in combination with time-lapse imaging. We found that GDNF signaling is dispensable for SC migration along murine embryonic sympathetic axons. Furthermore, in vivo analyzes revealed that SC migration along the sciatic nerve is also not dependent on GDNF. CONCLUSIONS: In contrast to previous in vitro findings in the sciatic nerve and a SC precursor cell line, our results clearly indicate that GDNF is dispensable for embryonic SC migration. This is demonstrated for the sympathetic nervous system and also for the sciatic nerve in mouse

Cooling a mechanical resonator via coupling to a tunable double quantum dot

We study the cooling of a mechanical resonator (MR) that is capacitively coupled to a double quantum dot (DQD). The MR is cooled by the dynamical backaction induced by the capacitive coupling between the DQD and the MR. The DQD is excited by a microwave field and afterwards a tunneling event results in the decay of the excited state of the DQD. An important advantage of this system is that both the energy level splitting and the decay rate of the DQD can be well tuned by varying the gate voltage. We find that the steady average occupancy, below unity, of the MR can be achieved by changing both the decay rate of the excited state and the detuning between the transition frequency of the DQD and the microwave frequency, in analogy to the laser sideband cooling of an atom or trapped ion in atomic physics. Our results show that the cooling of the MR to the ground state is experimentally implementable.Comment: 10 pages, 5 figure

Dissipation in nanocrystalline-diamond nanomechanical resonators

We have measured the dissipation and frequency of nanocrystalline-diamond nanomechanical resonators with resonant frequencies between 13.7 MHz and 157.3 MHz, over a temperature range of 1.4–274 K. Using both magnetomotive network analysis and a time-domain ring-down technique, we have found the dissipation in this material to have a temperature dependence roughly following T^(0.2), with Q^(–1) ≈ 10^(–4) at low temperatures. The frequency dependence of a large dissipation feature at ~35–55 K is consistent with thermal activation over a 0.02 eV barrier with an attempt frequency of 10 GHz

Enhancement of Cavity Cooling of a Micromechanical Mirror Using Parametric Interactions

It is shown that an optical parametric amplifier inside a cavity can considerably improve the cooling of the micromechanical mirror by radiation pressure. The micromechanical mirror can be cooled from room temperature 300 K to sub-Kelvin temperatures, which is much lower than what is achievable in the absence of the parametric amplifier. Further if in case of a precooled mirror one can reach millikelvin temperatures starting with about 1 K. Our work demonstrates the fundamental dependence of radiation pressure effects on photon statistics.Comment: 14 pages, 7 figure

Self-cooling of a micro-mirror by radiation pressure

We demonstrate passive feedback cooling of a mechanical resonator based on radiation pressure forces and assisted by photothermal forces in a high-finesse optical cavity. The resonator is a free-standing high-reflectance micro-mirror (of mass m=400ng and mechanical quality factor Q=10^4) that is used as back-mirror in a detuned Fabry-Perot cavity of optical finesse F=500. We observe an increased damping in the dynamics of the mechanical oscillator by a factor of 30 and a corresponding cooling of the oscillator modes below 10 K starting from room temperature. This effect is an important ingredient for recently proposed schemes to prepare quantum entanglement of macroscopic mechanical oscillators.Comment: 11 pages, 9 figures, minor correction

alpha-Amylase Production in Fed BatchCultivation of Bacillus caldolyticus: An Interpretation of FermentationCourseUsing 2-D Gel Electrophoresis

The conditions for increased production of thermostable a-amylase from Bacillus caldolyticus DSM 405 were investigated. Preliminary experiments in batch shake flasks led to an optimized initial cultivation medium. Shake flask experiments in extended-batch and in fed-batch mode of operation indicated that the a-amylase production was enhanced by continuous feeding of starch. The activity of the a-amylase with optimized initial medium in batch-operated shake flasks was 5.7 U mL–1 compared to 15.4U mL–1 in the extended-batch culture and 21 U mL–1 in fed-batch culture. The improvements were achieved by avoiding any excess of starch in medium that led to accumulation of glucose followed by acetate formation. Adding casitone as the second component of the feeding solution in an aerated and agitated fed-batch bioreactor (3-liter working volume) led to an increased -amylase activity of up to 163.7 U mL.–1 All phases of cultivation were analyzed using 2D-gel electrophoresis in combination with nano LC-ESI-MS/MS for identification of altered proteins. Pyruvate kinase, 6-phosphofructokinase, GltC, anti-sigma F factor, glycogen synthase and several important variable proteins were detected. With help of these results, potential improvements of a two-component feeding strategy are discussed