Chubby mothers-maternal and perinatal outcome in high body mass index

Background: Obesity is a state of excess adipose tissue mass. Body mass index (BMI) is a crucial predictor of nutritional status of pregnant women. High BMI may lead to various adverse maternal and perinatal outcomes. This study is designed to see the effect of maternal BMI on pregnancy outcome and perinatal outcome according to Asian standards.Methods: This is an institutional retrospective, descriptive study of 100 pregnant women conducted in the department of obstetrics and gynaecology of a rural tertiary centre Dr. PSIMS and RF, Chinaoutpalli, Gannavaram, Vijayawada, AP, India from June 2017 to July 2019.Results: It was observed that as BMI increased risk of complications increased like hypertension disorders in pregnancy, gestational diabetes mellitus, preterm labour. Also risk of macrosomia, operative delivery, Neonatal intensive care unit (NICU) admissions increased.Conclusions: As maternal BMI is a good predictor has strong correlation with pregnancy complications and outcomes, measures should be taken to motivate for pre pregnancy counselling regarding weight management and close surveillance in antenatal period to diagnose at the earliest any complications

An Ayurvedic perspective of Haemostatic Measures - A Review Article

The Raktadhatu i.e., the blood is given greater importance in life sciences, especially in the field of surgery. Acharya Susruta has even considered it as an important Dosha as Tridoshas in the etiopathology of diseases, its curative measures and in maintenance of health. To prevent loss of this entity, Acharya Susruta has elaborately described this under a specific heading namely Chaturvidha Rakta Sthambhana Upayas, namely Sandhana, Skandana, Dahana and Pachana. Sandhana is applying Kashayarasa Dravyas in different forms, suturing, ligation, application of pressure and pressure bandages etc. Skandhana is application of cold by any means. Pachana is application of caustic ashes and alkalis. Dahana is to burn by different means. In above methods haemostasis is achieved by inducing vasoconstriction, coagulation, mechanical and physical obliteration of vessels. Thus Skandana, Sandhana, Pachana, Dahana are the absolute haemostatic measures, understanding of which will equip surgeons to face haemorrhage with every available resources.&nbsp

Gaschromatography Mass Spectrometry GC MS Determination of Bioactive Components from Aervalanata. (L.) Whole Plant

Aervalanata L. belongs to the family of Amaranthaceae, found in the tropical regions. Traditionally, this plant is known for antimicrobial, anthelminthic, antiparasitic, antidiabetic, diuretic, nephroprotective, cytotoxic, and antihyperlipidemic activities. As yet no further characteristic study has been conducted from ethanolic extract of this species, therefore in this present study we seek to identify and evaluate the bioactive compounds from the ethanolic extracts of Aervalanata L whole plant by using the GCMS. Result of this research work reports twenty-eight compounds. The identified chemical compounds were correlated with the NIST Mass Spectrum Library.In conclusion, we seek to provide additional information on the clinical significance and pharmacological information associated with this plant

Plants used as Medicine by Paliyar Tribes of Shenbagathope in Virudhunagar District of Tamilnadu, India

The traditional medicinal uses of 58 angiospermic plant species belonging to 54 genera of 31 families for various diseases and ailments like wounds, cuts, stomach pain, diabetes, fever, cold, poisonous bites etc., by the Paliyar tribes of Shenbagathope in Virudhunagar district of Tamilnadu, India, are mentioned. Generally, fresh part of the plant is used for the preparation of medicine. When fresh plant parts are not available, dried parts are also used. Attention should be made on proper exploitation and utilization of these ethnomedicinally important plant species

Comparative efficacious study between preoperative pregabalin and gabapentin on postoperative pain in abdominal hysterectomy: an institutional experience

Background: Pain is a consistent and predominant complaint following surgical intervention including abdominal open hysterectomy. A multimodal approach has been suggested to improve postoperative analgesia and to reduce opioid related side effects. In this context we conducted a comparative study on efficacy between gabapentin and pregabalin on postoperative pain relief.Methods: In this prospective randomised study, 60 patients were divided in to two arms group G and group P. 900 mg of gabapentin and 300 mg of pregabalin were administered orally one hour before spinal anaesthesia to respective groups. Hemodynamic parameters such as heart rate, mean arterial pressure, respiratory rate was monitored pre, per and postoperatively. Also, the need for first analgesic dose and visual analog pain score were documented in all subjects of both groups. Statistical analysis with SPSS 16.0 performed.Results: There was significant fall in mean arterial pressure in group G than group P patients. Further the fall in mean pulse rate was more in group G compared to group P throughout pre, per and post-operative phases. In terms of mean postoperative time required for first dose of analgesic drug, pregabalin and gabapentin was required after 7 and 5 hours respectively. There was a statistically significant change in Visual Analogue Scale, showing pregabalin as better drug than gabapentin in post operative pain control with score 5 and 7 respectively.Conclusions: Pre-emptive analgesia with pregabalin appears to be superior to gabapentin as a part of multimodal perioperative pain management in abdominal hysterectomy

Study on HELLP syndrome - maternal and perinatal outcome

Background: HELLP Syndrome is a serious obstetric complication in pregnancy characterised by haemolysis, elevated liver enzymes and low platelet count. Incidence is 0.5-0.9% of all pregnancies and in 10-20% of cases with severe preeclampsia and eclampsia. The aim of the study was to study the incidence, different clinical presentations and diagnosis of HELLP syndrome in Pre eclampsia and Eclampsia and to analyze the severity, complications, maternal and perinatal outcome.Methods: It is a 16 months period retrospective study of 102 cases of preeclampsia and eclampsia admitted in NRIMC and GH in OBGY Department with more than 28 weeks gestation. Of these, 91 cases had preeclampsia and 11 cases had eclampsia. Out of these, 15 cases developed HELLP Syndrome. The available history, clinical data, detailed laboratory investigations were studied and categorized by Mississippi classification for better analysis of complications and outcome in HELLP syndrome.Results: Of 91 cases of Preeclampsia, 12 cases (13.18%) developed HELLP syndrome and out of 11 cases of Eclampsia, 3 cases (27.27%) had HELLP Syndrome. Majority of the cases belonged to 21-25years age group and were mostly from lower Socio economic status. The present study showed 60% maternal morbidity and 6.6% maternal mortality and the perinatal morbidity and mortality was 46.6% each.Conclusions: HELLP Syndrome is a severe variant and a dreadful complication of Preeclampsia and Eclampsia, it needs early diagnosis and timely intervention in the form of termination of pregnancy to arrest further progress of pathophysiology leading to complications

Laxative Property of Safoof-E-Sana, a Unani Formulation

An investigation was carried out to study the laxative property of aqueous extract Safoof-ESana in the unani formulation. Aqueous extract of Safoof-E-Sana was evaluated for laxative property and was measured by weighing the fecal out at 8th and 16th hour of drug administration. Safoof-E-Sana at 50, and 100 mg/kg showed dose dependent laxative effect. The results are compared with standard Senna. Safoof-E-Sana was showed significant laxative activity

PHARMACOGNOSTIC AND HPTLC BASED COMPARATIVE STUDY ON LEAVES OF MERREMIA EMARGINATA BURM. F. AND CENTELLA ASIATICA (L.) URBAN

Objective: In this study, an attempt was made to generate information based on botanical, physicochemical and HPTLC data needed for proper identification and authentication of M. emarginata and C. asiatica belonging to two different families. Methods: Botanical study comprises of macroscopy, microscopy and powder microscopy of leaves of both crude drugs. The physicochemical parameters such as water-soluble extractive, alcohol soluble extractive and loss on drying at 105℃, total ash, acid insoluble ash, and volatile oil were determined according to standard methods. HPTLC studies of chloroform extracts of leaves of both drugs were conducted at 254 nm, 366 nm and 575 nm after derivatisation using vanillin-sulphuric acid and the results were documented. Results: The present study reveals that microscopy and most of the physicochemical parameters of both the plant materials are different. Anatomy of the leaves showed two main characteristic differences. First plenty of trichome with trichome base and calcium oxalate crystal is common in M. emarginata, which is not observed in C. asiatica. Both plants have different venation patterns and leaf constants. The total ash content and the solubility in alcohol and water for leaves of C. asiatica are higher than that of M. emarginata. The HPTLC fingerprinting pattern obtained for both drugs are different. Conclusion: All the results obtained from this study help in determining differences and similarities of leaves of M. emarginata and C. asiatica and thereby preventing adulteration and substitution and emphasizing the importance of standardization

Central giant cell reparative granuloma of the maxilla in a 5-year-old child- A case Report

Central Giant Reparative Granuloma is a non-neoplastic lesion that most commonly affects the mandible and is uncommon in children. This case-report detailed the clinical features, diagnosis, treatment, and recall of a 5-year-old boy. The oral lesion is erythematous and consists of a 4x3 cm well-demarcated swelling on the anterior maxilla that extends across the midline and covers the entire length of the palate till the junction of the hard and soft palate. Upon radiographic and histologic investigation, it was conclusive of Central giant cell reparative granuloma (CGCG). The treatment comprised of a conservative approach that included excision of the lesion, thereby reducing the risk of tooth and bone loss