Public wrongs and the criminal law

This paper is about how best to understand the notion of ‘public wrongs’ in the longstanding idea that crimes are public wrongs. By contrasting criminal law with the civil laws of torts and contracts, it argues that ‘public wrongs’ should not be understood merely as wrongs that properly concern the public, but more specifically as those which the state, as the public, ought to punish. It then briefly considers the implications that this has on criminalization.AHRC (AH/H015655/1

Population health profile of the NSW Outback Division of General Practice: supplement

© Commonwealth of Australia To view the data presented in the profiles in Excel spreadsheets or via Interactive Mapping, please see the PHIDU website at: www.publichealth.gov.au

GSI3D model metadata report for HS2 area 8 (Drayton Bassett to Rugeley)

This report describes the 3D geological model of HS2 (High Speed 2 rail link) Area 8 (Drayton Basset to Rugeley), created by Keith Ambrose with support from Steve Thorpe. The model was created as part of a set of nine geological models that cover the proposed HS2 rail route from the end of the HS2 London model to Birmingham and the West Coast Main Line near Lichfield. The models were funded from the NERC/BGS Science Budget to promote BGS modelling and geological interpretation services to this important infrastructure project and to test methodologies and procedures for creating geological models by multiple compilers. The report describes the model construction and purpose, with spatial limits and scale, sources of information, data processing, workflow, decisions, assumptions, rules and limitations, together with images of the model

GSI3D model metadata report for HS2 area 7 (Hampton in Arden to Drayton Bassett)

This report describes the 3D geological model of HS2 (High Speed 2 rail link) Area 7 (Hampton in Arden to Drayton Bassett), created by Keith Ambrose with support from Steve Thorpe and borehole coding by John Powell. The model was created as part of a set of nine geological models that cover the proposed HS2 rail route from the end of the HS2 London model to Birmingham and the West Coast Main Line near Lichfield. The models were funded from the NERC/BGS Science Budget to promote BGS modelling and geological interpretation services to this important infrastructure project and to test methodologies and procedures for creating geological models by multiple compilers. The report describes the model construction and purpose, with spatial limits and scale, sources of information, data processing, workflow, decisions, assumptions, rules and limitations, together with images of the model

GSI3D model metadata report for HS2 area 5 (Ladbroke to Cubbington)

This report describes the 3D geological model of HS2 (High Speed 2 rail link) Area 5 (Ladbroke to Cubbington), created by Keith Ambrose with support from Steve Thorpe. The model was created as part of a set of nine geological models that cover the proposed HS2 rail route from the end of the HS2 London model to Birmingham and the West Coast Main Line near Lichfield. The models were funded from the NERC/BGS Science Budget to promote BGS modelling and geological interpretation services to this important infrastructure project and to test methodologies and procedures for creating geological models by multiple compilers. The report describes the model construction and purpose, with spatial limits and scale, sources of information, data processing, workflow, decisions, assumptions, rules and limitations, together with images of the model

Population health profile of the Northern Melbourne Division of General Practice

© Commonwealth of Australia To view the data presented in the profiles in Excel spreadsheets or via Interactive Mapping, please see the PHIDU website at: www.publichealth.gov.au

Developmental and Adult Basic Education Motivation and Optimism/Helplessness Model

Students in Developmental and Adult Basic Education often have very specific motivational needs; however, there is no model of motivation that describes these students’ experiences. This model synthesizes motivation research on those populations as well as motivational theories and models from psychology (including K-12 educational psychology)

Defending a communicative theory of punishment: the relationship between hard treatment and amends

According to communicative theories of punishment, legal punishment is pro tanto justified because it communicates the censure that offenders deserve for their crimes. The aim of this article is to offer a modest defence for a particular version of a communicative theory. This version builds on the one that has been advanced by Antony Duff. According to him, legal punishment should be understood as a kind of (secular) penitential burden that is placed upon offenders to censure them for their crimes, with the aims that they will then come to repent, reform themselves and reconcile with those whom they have wronged. This article departs from Duff’s version, however, by arguing that the penitential burdens in question should be understood more specifically in terms of the amends that offenders ought to make to apologise for their criminal wrongdoings. The article then attempts to address three potential objections to this revised version of the communicative theory.The Leverhulme Trust (ECF-2012-032

Duties of Minimal Wellbeing and Their role in Global Justice

This thesis is the first step in a research project which aims to develop an accurate and robust theory of global justice. The thesis concerns the content of our duties of global justice, under strict compliance theory. It begins by discussing the basic framework of my theory of global justice, which consists in two aspects: duties of minimal wellbeing, which are universal, and duties of fairness and equality, which are associative and not universal. With that in place, it briefly discusses the nature of duties of fairness and equality. I shall argue that they are associative, because they are derived from the form of cooperation at hand; and that there are three kinds of them in our contemporary world: states, local cooperation and trans-state cooperation. It is from their forms of cooperation that these duties are derived. After that, the thesis focuses exclusively on duties of minimal wellbeing. Against the usual account of these duties - the human-flourishing account - I argue for my human-life account. This account argues that the function of these duties is to secure a human life for individuals; and it begins with a Razian conception of wellbeing, which states that the wellbeing of an individual is fundamentally constituted by: (a) the satisfaction of his biological needs, and (b) his success in whole-heartedly pursuing socially defined and determined goals and activities which are in fact valuable. An account of what constitutes a human life is then derived from this conception of wellbeing – it is a life that consists in having a level of wellbeing that is higher than the satisfaction of biological needs, where this is constituted by the pursuit of goals and activities with a sense of what is worth doing; and this in turn consists in: (a) being able to forms ideas of what is worth doing, (b) being able to revise them in light of further reasons, and (c) being able to coordinate one's actions according to them. I then determine the specific objects of duties of minimal wellbeing (means for the satisfaction of biological needs, education, physical security, freedom of belief, association and expression, freedom of non-harmful conduct, and minimal resources), by determining what is involved in securing such a human life for individuals

Escaping death: how cancer cells and infected cells resist cell-mediated cytotoxicity

Cytotoxic lymphocytes are critical in our immune defence against cancer and infection. Cytotoxic T lymphocytes and Natural Killer cells can directly lyse malignant or infected cells in at least two ways: granule-mediated cytotoxicity, involving perforin and granzyme B, or death receptor-mediated cytotoxicity, involving the death receptor ligands, tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and Fas ligand (FasL). In either case, a multi-step pathway is triggered to facilitate lysis, relying on active pro-death processes and signalling within the target cell. Because of this reliance on an active response from the target cell, each mechanism of cell-mediated killing can be manipulated by malignant and infected cells to evade cytolytic death. Here, we review the mechanisms of cell-mediated cytotoxicity and examine how cells may evade these cytolytic processes. This includes resistance to perforin through degradation or reduced pore formation, resistance to granzyme B through inhibition or autophagy, and resistance to death receptors through inhibition of downstream signalling or changes in protein expression. We also consider the importance of tumour necrosis factor (TNF)-induced cytotoxicity and resistance mechanisms against this pathway. Altogether, it is clear that target cells are not passive bystanders to cell-mediated cytotoxicity and resistance mechanisms can significantly constrain immune cell-mediated killing. Understanding these processes of immune evasion may lead to novel ideas for medical intervention