dS-AdS structures in the non-commutative Minkowski spaces

We consider a family of non-commutative 4d Minkowski spaces with the signature (1,3) and two types of spaces with the signature (2,2). The Minkowski spaces are defined by the common reflection equation and differ in anti-involutions. There exist two Casimir elements and the fixing of one of them leads to non-commutative "homogeneous" spaces $H_3$, $dS_3$, $AdS_3$ and light-cones. We present the quasi-classical description of the Minkowski spaces. There are three compatible Poisson structures - quadratic, linear and canonical. The quantization of the former leads to the considered Minkowski spaces. We introduce the horospheric generators of the Minkowski spaces. They lead to the horospheric description of $H_3$, $dS_3$ and $AdS_3$. The irreducible representations of Minkowski spaces $H_3$ and $dS_3$ are constructed. We find the eigen-functions of the Klein-Gordon equation in the terms of the horospheric generators of the Minkowski spaces. They give rise to eigen-functions on the $H_3$, $dS_3$, $AdS_3$ and light-cones.Comment: 31 pages, LateX, typos corrected, references adde

Considerable enhancement of the critical current in a superconducting film by magnetized magnetic strip

We show that a magnetic strip on top of a superconducting strip magnetized in a specified direction may considerably enhance the critical current in the sample. At fixed magnetization of the magnet we observed diode effect - the value of the critical current depends on the direction of the transport current. We explain these effects by a influence of the nonuniform magnetic field induced by the magnet on the current distribution in the superconducting strip. The experiment on a hybrid Nb/Co structure confirmed the predicted variation of the critical current with a changing value of magnetization and direction of the transport current.Comment: 6 pages, 7 figure

Thermal Analysis of EPOS components

We present a simulation study of the thermal behaviour of essential parts of the electron-positron converter of the positron source EPOS at the Research Center Dresden-Rossendorf. The positron moderator foil and the upper tube element of the electrostatic extraction einzellens are directly exposed to the primary electron beam (40 MeV, 40 kW). Thus, it was necessary to prove by sophisticated simulations that the construction can stand the evolving temperatures. It was found that thin moderator foils (< 20...40 µm) will not show a too strong heating. Moreover, the temperature can be varied in a wide range by choosing an appropriate thickness. Thus, the radiation-induced lattice defects can at least partly be annealed during operation. The wall of the extraction lens which is made from a stainless steel tube must be distinctly thinned to avoid damage temperatures. The simulations were performed time dependent. We found that the critical parts reach their final temperature after less than a minute

HUWE1 E3 ligase promotes PINK1/PARKINindependent mitophagy by regulating AMBRA1 activation via IKKa

The selective removal of undesired or damaged mitochondria by autophagy, known as mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion, neurodegeneration and ageing. The pro-autophagic molecule AMBRA1 (autophagy/beclin-1 regulator-1) has been defined as a novel regulator of mitophagy in both PINK1/PARKIN-dependent and -independent systems. Here, we identified the E3 ubiquitin ligase HUWE1 as a key inducing factor in AMBRA1-mediated mitophagy, a process that takes place independently of the main mitophagy receptors. Furthermore, we show that mitophagy function of AMBRA1 is post-translationally controlled, upon HUWE1 activity, by a positive phosphorylation on its serine 1014. This modification is mediated by the IKKα kinase and induces structural changes in AMBRA1, thus promoting its interaction with LC3/GABARAP (mATG8) proteins and its mitophagic activity. Altogether, these results demonstrate that AMBRA1 regulates mitophagy through a novel pathway, in which HUWE1 and IKKα are key factors, shedding new lights on the regulation of mitochondrial quality control and homoeostasis in mammalian cells