Comparative analysis of hemodynamic characteristics of the biological xenogenic pericardial prosthesis MEDINGE-BIO with “easy change” system and the xenogenic aortic prosthesis Hancock II after aortic valve replacement

Aim. To compare the outcomes of aortic valve replacement using the xenogenic aortic prosthesis Hancock II and the novel Russian xenogenic pericardial prosthesis MEDINGE-BIO.Material and methods. The study included patients operated on for aortic stenosis in the cardiac surgery department № 1 of the Cardiology Research Institute (Tomsk National Research Medical Center). All patients were divided into two groups. The first group included 54 patients with Hancock II prostheses, the second — 91 patients with MEDINGE-BIO prostheses. Hemodynamic characteristics of heart valves were assessed by echocardiography before surgery and before discharge (on average 10 days after surgery).Results. When comparing hemodynamic parameters before and after surgery, significant differences between the groups were not obtained. The average pressure gradient after surgery using Hancock II and MEDINGE-BIO prosthesis was 21,6±7,9 and 17,9±5,6 mm Hg, respectively (p=0,05).Conclusion. The comparative analysis showed that the novel biological prosthesis MEDINGE-BIO has comparable hemodynamic characteristics with the well-known aortic prosthesis Hancock II

Influence of implantation of a novel domestic prosthetic aortic valve on the functional class of heart failure one year after surgery

Aim. To assess the severity of heart failure (HF) 1 year after aortic valve replacement with a novel bioprosthetic valve with the “easy change” system.Material and methods. The study included 59 patients (24 men and 35 women) diagnosed with degenerative aortic valve disease without concomitant cardiac pathology. The mean age of the patients was 69,6±4,3 years. An assessment of NYHA HF class using six-minute walk test was carried out. The venous plasma level of N-terminal pro-brain natriuretric peptide (NT-proBNP) before and after surgery was also used to determine the severity of HF. In 31 patients (52,5%), NYHA class III HF was determined before surgery.Results. Comparative analysis of HF classes revealed a significant difference. Thus, after implantation of MedEng-BIO prosthetic aortic valve, the distance of the six-minute walk test increased by an average of 125 m (p=0,001). NT-proBNP level decreased from 162,2 pg/ml to 63,7 pg/ml (p=0,003).Conclusion. One-year follow-up of patients after implantation of a novel bioprosthetic aortic valve showed an objective decrease in the severity of HF according to six-minute walk test and NT-proBNP level in venous blood plasma

Первый клинический случай имплантации составного каркасного ксеноперикардиального биопротеза в митральную позицию

The article presents the first clinical case of the implantation of a composite frame xenopericardial bioprosthesis “MedEng-Bio” in the mitral position. The special design of the prosthesis implantation procedure simplifies and reduces the risks associated with possible repeated operations.В статье представлен первый клинический случай имплантации составного каркасного ксеноперикардиального биопротеза «МедИнж-Био» в митральную позицию. Особая конструкция протеза упрощает процедуру имплантации и позволяет уменьшить риски при возможных повторных операциях

Efficient silver nanoparticles deposition method on DBD plasma-treated polyamide 6,6 for antimicrobial textile

The study of antimicrobial fabrics with silver nanoparticles (AgNPs) incorporation has shown excellent properties in medical, pharmaceutical, cosmetics and electronics applications due to their formidable action against pathogens, preventing and treating infections.[1] The high surface-to-volume ratio from AgNPs promotes an easy release of silver ion, responsible for the antimicrobial effect.[2] The most traditional method for nanoparticles deposition onto fabrics is the pad-dry-cure technique.[3] Other methods were developed such as dip coating, electrochemical methods and layer-by-layer depositions.[4-6]. However, the major methods have several limitations for noble metals. In this work, several methods for AgNPs deposition on Dielectric barrier discharge (DBD) plasma pre-treated polyamide 6,6 (PA66) were tested for the production of durable antibacterial textiles. DBD plasma was previously used for surface modification to increase surface energy through the introduction of polar groups altering wettability and roughness.[7] However, the study for an efficient deposition methods after plasma treatment was disregarded. SEM, XPS, cytotoxicity and antimicrobial tests were performed to evaluate the different deposition methods.info:eu-repo/semantics/publishedVersio

The first clinical case of implantation of a composite frame xenopericardial bioprosthesis “MedEng-Bio” in the mitral position

The article presents the first clinical case of the implantation of a composite frame xenopericardial bioprosthesis “MedEng-Bio” in the mitral position. The special design of the prosthesis implantation procedure simplifies and reduces the risks associated with possible repeated operations