Role of modified biophysical profile and cerebroplacental ratio in fetal outcome in low risk and high risk pregnancies

Background: The timely detection of morbid changes in the fetal status followed by adequate interventions to avoid death or disability is one of the most important objectives of prenatal care. Objective of present study was to Comparing the role of modified biophysical profile and the cerebroplacental ratio in fetal outcome in low risk and high risk pregnancies.Methods: Two hundred and seventy three singleton pregnant women were included in this study. Following routine examination, amniotic fluid index, pulsatility index of middle cerebral artery and pulsatility index of umbilical artery, uterine artery mean pulsatility index were evaluated. Non stress test (NST) was done. Modified biophysical profile (MBPP) and Cerebroplacental ratio (CPR in percentile) was generated. Caeserean section because of Fetal distress, birth weight 24hours were used in evaluating the perinatal outcome.Results: Out of 273 cases, 107 cases had poor perinatal outcome. Out of 107 cases, 35.5% cases were IUGR, 39.2% cases underwent caesarean section in view of fetal distress, 39.2% babies had 5min APGAR 24hrs. In high risk cases, poor perinatal outcome was seen in 45.5% pregnancies and 36.7% in low risk pregnancies. Sixty seven percent of these cases had abnormal modified biophysical profile and only 7.4% cases had cerebroplacental ratio <1.Conclusions: Modified biophysical profile was proved to be more significant than cerebroplacental ratio in prediction of perinatal outcome.

Synthesis, characterization and evaluation of new thiazole derivatives as anthelmintic agents

A series of 2-amino substituted 4-phenyl thiazole derivatives has been synthesized by the conventional method. The thiazole derivatives have been synthesized by three steps. The obtained five derivatives have been purified by recrystallization process by using methanol as solvent and column chromatography [IVd Compound] and have been characterized by melting point, TLC, FTIR, 1H NMR and mass spectral data. All the five derivatives have been evaluated using in silico studies by using different softwares (Lipinski’s Rule of 5, OSIRIS molecular property explorer, Molsoft molecular property explorer, PASS and docking studies). These compounds have then been evaluated for anthelmintic activity against Indian adult earth worms (Pheretima postuma). All the compounds show significant anthelmintic activity. The compound IVc and IVe are shown to be potent compounds when compared with the standard drug (Mebendazole). Molecular docking studies have guided and prove the biological activity of the sythesised compounds against beta tubulin protein (1OJ0).

Performance Enhancement of Cisc Microcontroller

Increase in the speed of the system always demands for a major alteration on the existing system, which result in overall cost of the implementation of a system. Generally, CISC controllers are used for control operations, which have large number of instruction sets and take a large amount for processing due to its multiple sizes. For very high speed of controlling these controllers may fail to operate properly. The alternate solution is the RISC controllers, which are considerably faster than the normal CISC controllers. But these controllers have got various limitations as less instruction operations, complex register operation, costlier than the CISC controller etc. The only solution to this problem is the enhancement to the operational speed of a CISC controller, by enhancing the overall controller operation. Additionally, today�s controller doesn�t support the floating-point operation for signal processing. The enhancement of existing CISC controller by pipelining the overall operational flow of a CISC microcontroller and it includes the enhancement of UART. This research work is to be implemented using VHDL language and simulated using Active-HDL tool for functional verification

LowDINO -- A Low Parameter Self Supervised Learning Model

This research aims to explore the possibility of designing a neural network architecture that allows for small networks to adopt the properties of huge networks, which have shown success in self-supervised learning (SSL), for all the downstream tasks like image classification, segmentation, etc. Previous studies have shown that using convolutional neural networks (ConvNets) can provide inherent inductive bias, which is crucial for learning representations in deep learning models. To reduce the number of parameters, attention mechanisms are utilized through the usage of MobileViT blocks, resulting in a model with less than 5 million parameters. The model is trained using self-distillation with momentum encoder and a student-teacher architecture is also employed, where the teacher weights use vision transformers (ViTs) from recent SOTA SSL models. The model is trained on the ImageNet1k dataset. This research provides an approach for designing smaller, more efficient neural network architectures that can perform SSL tasks comparable to heavy model

PREVALENCE OF SUBCLINICAL HYPOCALCAEMIA and subclinical ketosis in buffaloes

ABSTRACT The present study was undertaken to while buffaloes in fi rst parity were least affected by the two conditions. The prevalence of both conditions was higher in organised dairy farms than the unorganised dairy units. Of the diagnostic tests utilised for SCH, estimation of serum calcium levels was found superior to the Sulkowitch test while for SCK, estimation of blood ketones was found superior to Rothera&apos;s test and the urine dip stick test

Synthesis, characterization and evaluation of new thiazole derivatives as anthelmintic agents

616-623A series of 2-amino substituted 4-phenyl thiazole derivatives has been synthesized by the conventional method. The thiazole derivatives have been synthesized by three steps. The obtained five derivatives have been purified by recrystallization process by using methanol as solvent and column chromatography [IVd Compound] and have been characterized by melting point, TLC, FTIR, 1H NMR and mass spectral data. All the five derivatives have been evaluated using in silico studies by using different softwares (Lipinski’s Rule of 5, OSIRIS molecular property explorer, Molsoft molecular property explorer, PASS and docking studies). These compounds have then been evaluated for anthelmintic activity against Indian adult earth worms (Pheretima postuma). All the compounds show significant anthelmintic activity. The compound IVc and IVe are shown to be potent compounds when compared with the standard drug (Mebendazole). Molecular docking studies have guided and prove the biological activity of the sythesised compounds against beta tubulin protein (1OJ0)

Preparation and characterization of electroless Ni coated nano alumina powder under different sensitization - activation conditions

The development of electroless coatings on various substrates has gained much interest among researchers for the sake of improved properties. However, the coating on ceramic particles as a source of reinforcement is still a challenge for the researchers and requires a good comprehension of fundamentals since the coating thickness relies upon many parameters. Particularly the sensitization and activation conditions are more important for the creation of an ideal environment to draw metallic ions as a coating layer. Therefore, this paper examines the role of sensitization and activation conditions on the viability of nickel coating on the alumina particles of an average size of 50 nm. A comparison is made between two environments, namely individual and blended activations in the preparation of coated particles. Characterization studies are also presented to support the discussion.&nbsp

Clinical profile of dengue fever with severe thrombocytopenia and its complications: a retrospective study at a tertiary care hospital in South India

Background: Dengue haemorrhagic fever is a potentially lethal illness that is universally prevalent in the tropics and has become a major health concern globally in recent decades. The clinical manifestation of dengue infection varies from asymptomatic to severe life threatening illness in the form of DHF/DSS. Dengue haemorrhagic fever or DSS may be fatal in 40% to 50% of untreated patients. A hallmark of dengue infection is severe thrombocytopenia which causes concern for the patients and treating doctors. The objective of this study was to correlate clinical profile during the evolution of dengue fever with severe thrombocytopenia (platelets <10,000/mm3), and comparing frequencies between the different clinical forms in order to predict the severity of the disease.  The present study includes 40 individuals who were found to be seropositive with the detection of NS1Ag, IgM and IgG antibodies for dengue infection with severe thrombocytopenia. Early diagnosis and monitoring is largely dependent on haematological parameters. As no specific antiviral therapy is available, supportive therapy is of utmost importance.Methods: This is an observational, descriptive and retrospective study of 40 patients with clinical and serological diagnosis of dengue fever with severe thrombocytopenia (platelets<10,000/mm3), in the period from August 2015 to September 2016, who were admitted in a tertiary care hospital in South India. ELISA was performed for the detection of dengue NS1, Ig M and Ig G, haematological parameters by automated analyzer and peripheral smear, coagulation profile analysis were done.Results: Out of 40 cases with severe thrombocytopenia, 50% of the patients had classical dengue fever, 30% cases had DHF with bleeding manifests and 20% cases with DHF plasma leakage signs and 5% lead to DSS. There was lack of association studied between severe thrombocytopenia and bleeding manifestations as p value<0.065 was insignificant. However, the risk of complications increased with decreasing platelet counts in the present study.Conclusions: Thrombocytopenia was most predominant haematological discrepancy. There was no predilection for any age group or gender for thrombocytopenia or bleeding among the dengue patients. The results were relevant in assessing the severity of infection and can help by enabling the adaptation of the therapeutic conduct to the needs of individual patients