140 research outputs found
Strategic communication and the entrepreneurial role of the corporate communication officer
Considering the recent evolution of the communication/PR profession in large
organizations both private and public, many scholars agree that a process of
institutionalization is occurring. In other words, communicationâs importance
has been growing, reaching in recent years a strategic position as a lever for
companiesâ governance.
A first objective of this chapter is to describe, looking at management and
communication/PR literature, how and to what extent communication has
become strategic. The main hypothesis is that communication has become
strategic within companiesâ governance in order to help each organization
to develop consistently â mainly in terms of values â within its environment.
A second objective is to describe, looking at the entrepreneurial organization
theory and communication/PR literature, another side of the strategic
evolution of communication, which is to help each organization to develop â
mainly in terms of services, products and reputation â as a different, or preferably
unique, entity as compared to the other organizations.
The evolution of the strategic contribution of communication/PR within
organizationsâ decision-making has a strong impact on the role that corporate
communication officers (CCOs) play in organizations both on the isomorphic
and on the entrepreneurialâinnovative sides of the communicational activity
they carry out to support the evolution of their organizations
High-risk HPV E5-induced cell fusion: a critical initiating event in the early stage of HPV-associated cervical cancer
<p>Abstract</p> <p>Background</p> <p>Cervical cancer is strongly associated with high-risk human papillomavirus (HPV) and viral oncoproteins E5, E6 and E7 can transform cells by various mechanisms. It is proposed that oncogenic virus-induced cell fusion may contribute to oncogenesis if p53 or apoptosis is perturbed simultaneously. Recently, HPV-16 E5 was found to be necessary and sufficient for the formation of tetraploid cells, which are frequently found in precancerous cervical lesions and its formation is strongly associated with HPV state.</p> <p>Presentation of the hypothesis</p> <p>We propose that high-risk HPV E5-induced cell fusion is a critical initiating event in the early stage of HPV-associated cervical cancer.</p> <p>Testing the hypothesis</p> <p>Our hypothesis can be tested by comparing the likelihood for colony formation or tumorigenic ability in nude mice between normal HaCaT cells expressing all three oncogenic proteins and E5-induced bi-nucleated HaCaT cells expressing E6 and E7. Moreover, investigating premature chromosome condensation (PCC) in HPV-positive and negative precancerous cervical cells is another way to assess this hypothesis.</p> <p>Implication of the hypothesis</p> <p>This viewpoint would change our understanding of the mechanisms by which HPV induces cervical cancer. According to this hypothesis, blocking E5-induced cell fusion is a promising way to prevent the progression of cervical cancer. Additionally, establishment of a role of cell fusion in cervical carcinogenesis is of reference value for understanding the pathogenesis of other virus-associated cancers.</p
Biochronostratigraphy and paleoenvironment analysis of Neogene deposits from the Pelotas Basin (well 2-TG-96-RS), Southernmost Brazil
EMPIRICAL COMPARISON OF THE MULTIDIMENSIONAL MODELS OF ITEM RESPONSE THEORY IN E-COMMERCE
Public relations research: European and international perspectives and innovations
This volume is a major contribution to the trans-national debate on public relations research and communication management. It presents dominant concepts and findings from the scientific community in Germany in English language. At the same time, the compilation contains a selection of the most influential and relevant approaches from European and international researchers. Editors and contributors are renowned academics from all over the world. This books honours Guenter Bentele, one of the international spearheads of public relations research, and gives academics, students and communication managers a focussed insight into the field
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