Role of metallurgical factors in structure and property formation for thick plates of alloys of the Al-Cu-Mg-Mn system

The role of chemical composition is studied in thick plate structure and property formation for alloys of the Al-Cu-Mg-Mn system. It is shown that in order to correct the chemical composition of aluminum alloys it is necessary to consider the alloying element compatible solubility limit within an aluminum matrix at the heating temperature for hardening and the proportion of alloying elements participating in forming almost insoluble phases with impurity elements. An important role is also played by alloying elements formed with reaction of excess phases, although they are soluble but cannot be dissolved during heating for hardening due to saturation of α-solid solution with alloying elements. © 2013 Springer Science+Business Media New York

Phase formation during nonequilibrium crystallization of Al-Mg-Si system alloys

Nonequilibrium crystallization of alloys of the Al-Mg-Si system, and also their structure and phase composition in a cast condition are studied. Thermal analysis is used to establish phase transformation temperature ranges, occurring during nonequilibrium crystallization of industrial aluminum alloys AD31 and AD33. x-Ray microanalysis is used to determine metastable phase composition in the alloys in a cast condition. © 2013 Springer Science+Business Media New York

A Single-Loop DC Motor Control System Design with a Desired Aperiodic Degree of Stability

The application of the original analytical approach for Pi-controller synthesis of a stable second-order plant is considered. This approach allows finding controller parameters without any intensive computing by using the direct expressions. The plant model is obtained on the basis of identification, which is based on the automated real-interpolation method. The results of natural experiments are given

Effectiveness of mindfulness-based therapy, stress reduction in hypertension and prehypertension: a systematic review

Aim. To collect and analyze currently available clinical studies on the effectiveness of mindfulness-based stress reduction (MBSR) for lowering blood pressure in individuals with normal, high normal blood pressure and hypertension.Material and methods. The systematic review was prepared according to the PRISMA algorithm with minor modifications. The search algorithm included articles in Russian and English, indexed in the Pubmed/MEDLINE and Cochrane Library databases. The study included studies on the impact of mindfulness interventions on blood pressure levels in individuals aged ≥18 years with an established diagnosis of hypertension, with normal (120-129/80-84 mm Hg) and high normal office blood pressure (130-139/85-89 mm Hg).Results. A total of 4785 publications were identified and included in the study, of which, after a multistage sampling, including screening of articles, 6 studies were included in a qualitative systematic review.Conclusion. Qualitative synthesis of the results of clinical studies revealed that the evidence currently available indicates a possible positive effect of mindfulness interventions on blood pressure levels in individuals with normal, high normal blood pressure and hypertension. However, further studies with larger samples and measurement of more primary and secondary endpoints are required

Mobile applications for anxiety and stress reduction: potential for preventing noncommunicable diseases

The article discusses using mobile applications for smartphones as tools to reduce anxiety and stress. The modern views on pathogenesis of the relationship between stress, anxiety disorders and cardiovascular disease are considered. Based on a review of some representative studies, a methodology for evaluating the characteristics and functions of mobile applications for managing anxiety and stress symptoms is proposed. The applications selected for analysis were tested according to this methodology. There are following key features of the Russianlanguage field of mobile applications for anxiety and stress reduction: a small number of applications, high prevalence of using breathing exercises, meditations and sound therapy, an extremely low disease specificity and focus mainly on helping with general symptoms of anxiety

Assessment of the quality of mobile applications for smoking cessation and its potential for the modification of psychosocial and behavioral risk factors for cardiovascular disease

Aim. To analyze the functionality and characteristics of quit smoking applications available to Russian-speaking users using validated scales for its evaluation.Material and methods. Applications were searched in the App Store and Google Play, and a specialized MARS scale was used to evaluate applications. A total of 598 applications were found, of which 54 applications met the inclusion criteria and were included in the study.Results. It was found that 54% of applications use short- and medium-term goals as methods and techniques to increase the likelihood of quitting tobacco, while 31% of applications use various educational materials in order to form a negative attitude towards smoking. In addition, 22% of applications use cognitive and behavioral techniques of cognitive behavioral therapy. A negative moderate correlation was established between the application user rating and MARS score (r=-0,32).Conclusion. The Russian-language anti-smoking mobile applications included in this study demonstrated satisfactory quality on average. A significant number of applications use proven effective cognitive behavioral therapy techniques. At the same time, mobile applications in healthcare has shortcomings, especially in terms of compliance with guidelines, and needs to be further improved

Geometric and Statistical Properties of the Mean-Field HP Model, the LS Model and Real Protein Sequences

Lattice models, for their coarse-grained nature, are best suited for the study of the ``designability problem'', the phenomenon in which most of the about 16,000 proteins of known structure have their native conformations concentrated in a relatively small number of about 500 topological classes of conformations. Here it is shown that on a lattice the most highly designable simulated protein structures are those that have the largest number of surface-core switchbacks. A combination of physical, mathematical and biological reasons that causes the phenomenon is given. By comparing the most foldable model peptides with protein sequences in the Protein Data Bank, it is shown that whereas different models may yield similar designabilities, predicted foldable peptides will simulate natural proteins only when the model incorporates the correct physics and biology, in this case if the main folding force arises from the differing hydrophobicity of the residues, but does not originate, say, from the steric hindrance effect caused by the differing sizes of the residues.Comment: 12 pages, 10 figure