Glycemic control and long-acting insulin analog utilization in patients with type 2 diabetes

Introduction: The objective was to compare glycemic control, insulin utilization, and body weight in patients with type 2 diabetes (T2D) initiated on insulin detemir (IDet) or insulin glargine (IGlar) in a real-life setting in the Netherlands. Methods: Insulin-naïve patients with T2D, starting treatment with IDet or IGlar between January 1, 2004 and June 30, 2008, were selected from the PHARMO data network. Glycemic control (hemoglobin A1c [HbA1c]), target rates (HbA1c <7%), daily insulin dose, and weight gain were analyzed comparing IDet and IGlar for patients with available HbA1c levels both at baseline and at 1-year follow-up. Analysis of all eligible patients (AEP) and a subgroup of patients without treatment changes (WOTC) in the follow-up period were adjusted for patient characteristics, propensity scores, and baseline HbA1c. Results: A total of 127 IDet users and 292 IGlar users were included in the WOTC analyses. The mean HbA1c dropped from 8.4%-8.6% at baseline to 7.4% after 1 year. Patients at HbA1c goal increased from 9% at baseline to 32% for IDet and 11% to 35% for IGlar, which was not significantly different (OR 0.75, 95% CI 0.46, 1.24). Weight gain (n=90) was less among IDet users (+0.4kg) than among IGlar users (+1.1kg), albeit not significant. The AEP analysis (252 IDet

A RECURSIVE PROCESS ALGEBRA FOR QUEUES

We present a new algebra for processes that involve queueing operations. The algebra uses operators from CSP with extensions that uses dynamical event alphabets [1] and a new process operator for modeling FIFO process queueing. Two methods are suggested for deriving a buffered automaton from a given I/O (Mealy) automaton and the second one is applied to derive a general algebraic model for an SDL program. The algebra has the power to express the global state of an SDL program in terms of an algebraic expression and Can be used as a tool for verification and animation purposes. The idea, in principle, is applicable to the specification language ESTELLE and can also be integrated in LOTOS to avoid using ADTs for FIFO queues

Is there an increase in the prevalence of allergic diseases among schoolchildren from the Aegean region of Turkey?

WOS: 000232906800015PubMed ID: 16450577The prevalence of asthma, allergic rhinitis, allergic conjunctivitis, and allergic skin disorders (urticaria and atopic dermatitis) was investigated between the years 1993 and 1994 in the Aegean region of Turkey and was found to be 3.8, 4.6, 12.6, and 19.4%, respectively (Tanac R, Kurugol Z, Demir E, et at., (Cocuk Sagligi ve Hast Derg 39:77-85, 1996). The aim of the present study was to determine whether there is a change in the prevalence of allergic diseases in the Aegean region in the last 8 years, based on the comparison of the results using the same method applied in the study mentioned above. Three thousand three hundred seventy children (48.6% male participants and 51.4% female participants) between the ages of 5 and 18 years (mean age, 11.55 +/- 3.34 years) were enrolled in the study. The participants were randomly chosen among children attending primary schools in the cities of the Aegean region. The children completed a questionnaire; and physical examinations, serum-specific immunoglobulin E antibody levels, and peak expiratory flow measurements were done for each of them. Of the children, 21.2% were,found to have at least one attack of wheezing whereas the prevalence of asthma was 6.4%. The prevalence (of allergic rhinitis, allergic conjunctivitis, and allergic skin disorders (urticaria and atopic dermatitis) were found to be 13.6, 13.2, and 23.7%, respectively. The increase of prevalence for asthma was 2.6%, for allergic rhinitis was 9%, and for allergic conjunctivitis was 0.6%. These data show that the prevalence of allergic diseases, especially respiratory allergy, has increased among schoolchildren from the Aegean region of Turkey

Stable electrospinning composition for stable nano-/submicrostructure production and preparation method thereof

The present invention proposes an electrospinning composition comprising a catalyst and a functionalized polymer or copolymer bearing one or more epoxy ring, said mixture further comprises an anhydride, preferably phthalic anhydride as a crosslinking agent; wherein the epoxy:anhydride molar ratio in the electrospinning composition is within the range between 1:1 and 50:1. The present invention further proposes a method for preparation of such electrospinning composition, electrospun nano/ submicrostructures prepared using said method and composite material comprising such electrospun nano/ submicrostructures