High-quality positrons from a multi-proton bunch driven hollow plasma wakefield accelerator

By means of hollow plasma, multiple proton bunches work well in driving nonlinear plasma wakefields and accelerate electrons to energy frontier with preserved beam quality. However, the acceleration of positrons is different because the accelerating structure is strongly charge dependent. There is a discrepancy between keeping a small normalized emittance and a small energy spread. This results from the conflict that the plasma electrons used to provide focusing to the multiple proton bunches dilute the positron bunch. By loading an extra electron bunch to repel the plasma electrons and meanwhile reducing the plasma density slightly to shift the accelerating phase with a conducive slope to the positron bunch, the positron bunch can be accelerate to 400 GeV (40% of the driver energy) with an energy spread as low as 1% and well preserved normalized emittance. The successful generation of high quality and high energy positrons paves the way to the future energy frontier lepton colliders.Comment: 14 pages, 5 figure

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.

KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex. KDM2B targets c-Fos for polyubiquitylation and regulates c-Fos protein levels. Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes substrates binding to F-box, epidermal growth factor (EGF)-induced c-Fos S374 phosphorylation dissociates c-Fos from KDM2B and stabilizes c-Fos protein. Non-phosphorylatable and phosphomimetic mutations at S374 result in c-Fos protein which cannot be induced by EGF or accumulates constitutively and lead to decreased or increased cell proliferation, respectively. Multiple tumor-derived KDM2B mutations impaired the function of KDM2B to target c-Fos degradation and to suppress cell proliferation. These results reveal a novel function of KDM2B in the negative regulation of cell proliferation by assembling an E3 ligase to targeting c-Fos protein degradation that is antagonized by mitogenic stimulations

Hybrid exciton-polaritons in a bad microcavity containing the organic and inorganic quantum wells

We study the hybrid exciton-polaritons in a bad microcavity containing the organic and inorganic quantum wells. The corresponding polariton states are given. The analytical solution and the numerical result of the stationary spectrum for the cavity field are finishedComment: 3 pages, 1 figure. appear in Communications in Theoretical Physic

Characterization of the Soluble Nanoparticles Formed through Coulombic Interaction of Bovine Serum Albumin with Anionic Graft Copolymers at Low pH

A static light scattering (SLS) study of bovine serum albumin (BSA) mixtures with two anionic graft copolymers of poly (sodium acrylate-co-sodium 2-acrylamido-2-methyl-1-propanesulphonate)-graft-poly (N, N-dimethylacrylamide), with a high composition in poly (N, N-dimethylacrylamide) (PDMAM) side chains, revealed the formation of oppositely charged complexes, at pH lower than 4.9, the isoelectric point of BSA. The core-corona nanoparticles formed at pH = 3.00, were characterized. Their molecular weight and radius of gyration were determined by SLS, while their hydrodynamic radius was determined by dynamic light scattering. Small angle neutron scattering measurements were used to determine the radius of the insoluble complexes, comprising the core of the particles. The values obtained indicated that their size and aggregation number of the nanoparticles, were smaller when the content of the graft copolymers in neutral PDMAM side chains was higher. Such particles should be interesting drug delivery candidates, if the gastrointestinal tract was to be used

Interference Cancellation at Receivers in Cache-Enabled Wireless Networks

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Interference Cancellation at Receivers in Cache-Enabled Wireless Networks

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