Brackish water culture fisheries: A comment

Based on the papers and proceedings of The National Workshop on Development of Inland Fishery Resources, sponsored by the Ministry of Agriculture, Govemment of India, and held during November 1-3, 1983 at Ahmedabad under the joint auspices of the Centre for Management in Agriculture, Indian Institute of Management, Ahmedabad, and the Indian Society of Agricultural Economics, Bomba

Application and Analysis of Machine Learning Algorithms on Pima and Early Diabetes Datasets for Diabetes Prediction

Diabetes is a chronic condition that strike how your body burns food for energy. Much of the food you consume is converted by your body into sugar (glucose), which is then released into your bloodstream. Your pancreas releases insulin when your blood sugar levels rise. Over the years, several scholars have sought to create reliable diabetes prediction models. Due to a lack of adequate data sets and prediction techniques, this discipline still faces many unsolved research issues, which forces researchers to apply big data analytics and ML-based methodology. Four distinct machine learning algorithms are used in the study to analyze healthcare prediction analytics and solve the issues. In this investigation, the Pima and Early detection datasets were employed. We applied the Decision Tree, MLP, Naive Bayes, and Random Forest algorithms to these datasets and evaluated the accuracy and F-Measure. The goal of this research is to develop a system that could more precisely predict a patient's risk of developing diabetes

Physical Association of PDK1 with AKT1 Is Sufficient for Pathway Activation Independent of Membrane Localization and Phosphatidylinositol 3 Kinase

Frequent activation of the AKT serine-threonine kinase in cancer confers resistance to therapy. AKT is activated by a multi-step process involving phosphatidylinositide (PtdIns) phosphate-mediated recruitment of AKT and its upstream kinases, including 3-Phosphoinositide-dependent kinase 1 (PDK1), to the inner surface of the cell membrane. PDK1 in the appropriate context phosphorylates AKT at threonine 308 (T308) to activate AKT. Whether PtdIns(3,4,5)Ps (PtdInsP3) binding and AKT membrane translocation mediate functions other than formation of a functional PDK1::AKT complex have not been fully elucidated. We fused complementary fragments of intensely fluorescent protein (IFP) to AKT1 and PDK1 to induce a stable complex to study the prerequisites of AKT1 phosphorylation and function. In the stabilized PDK1-IFPC::IFPN-AKT1 complex, AKT1 T308 phosphorylation was independent of PtdIns, as demonstrated by treatment with Phosphatidylinositol 3 Kinase (PI3K) inhibitors. Further when interaction with PtdIns and the cell membrane was prevented by creating PH-domain mutants of AKT1 (R25A) and PDK1 (R474A), AKT1 phosphorylation on T308 was maintained in the PDK1-IFPC::IFPN-AKT1 complex. The PDK1-IFPC::IFPN-AKT1 complex was sufficient for phosphorylation of known AKT substrates, and conferred resistance to inhibitors of PI3K (LY294002, PI103, GDC0941 and TGX286) but not inhibitors of the downstream TORC1 complex (rapamycin). Thus the locus of action of targeted therapeutics can be elucidated by the constitutively active AKT1 complex. Our data indicate that PtdIns and membrane localization are not required for AKT phosphorylation and activation, but rather serve to induce a functional physical interaction between PDK1 and AKT. The PDK1-IFPC::IFPN-AKT1 complex provides a cell-based platform to examine specificity of drugs targeting PI3K pathway components

Multifaceted incorporation of Zn-Al2O3/Cr2O3/SiO2 nanocomposite coatings: anti-corrosion, tribological, and thermal stability

Nano-sized particle incorporation into metal matrix has gained worldwide acceptance. Al2O3, Cr2O3, and SiO2 nanoparticles have been co-deposited with Zn using electrodeposition process to produce advanced alloy. The coatings were characterized using SEM/EDX and XRD. The mechanical properties of the coatings were studied using microhardness indenter and dry abrasive wear tester. Zn-10 g/L Cr2O3 nanocomposite exhibited the highest microhardness of 228 HVN; Zn-5 g/L Al2O3 nanocomposite possessed the highest corrosion resistance and lowest wear loss. Zn-5 g/L SiO2 nanocomposite showed good stability against other composite coatings. The incorporation of the Al2O3, Cr2O3, and SiO2 shows grain refinement and modify orientation on Zn matrix

The NKF-NUS hemodialysis trial protocol - a randomized controlled trial to determine the effectiveness of a self management intervention for hemodialysis patients

<p>Abstract</p> <p>Background</p> <p>Poor adherence to treatment is common in patients on hemodialysis which may increase risk for poor clinical outcomes and mortality. Self management interventions have been shown to be effective in improving compliance in other chronic populations. The aim of this trial is to evaluate the effectiveness of a recently developed group based self management intervention for hemodialysis patients compared to standard care.</p> <p>Methods/Design</p> <p>This is a multicentre parallel arm block randomized controlled trial (RCT) of a four session group self management intervention for hemodialysis patients delivered by health care professionals compared to standard care. A total of 176 consenting adults maintained on hemodialysis for a minimum of 6 months will be randomized to receive the self management intervention or standard care. Primary outcomes are biochemical markers of clinical status and adherence. Secondary outcomes include general health related quality of life, disease-specific quality of life, mood, self efficacy and self-reported adherence. Outcomes will be measured at baseline, immediately post-intervention and at 3 and 9 months post-intervention by an independent assessor and analysed on intention to treat principles with linear mixed-effects models across all time points. A qualitative component will examine which aspects of program participants found particularly useful and any barriers to change.</p> <p>Discussion</p> <p>The NKF-NUS intervention builds upon previous research emphasizing the importance of empowering patients in taking control of their treatment management. The trial design addresses weaknesses of previous research by use of an adequate sample size to detect clinically significant changes in biochemical markers, recruitment of a sufficiently large representative sample, a theory based intervention and careful assessment of both clinical and psychological endpoints at various follow up points. Inclusion of multiple dependent variables allows us to assess the broader impact on the intervention including both hard end points as well as patient reported outcomes. This program, if found to be effective, has the potential to be implemented within the existing renal services delivery model in Singapore, particularly as this is being delivered by health care professionals already working with hemodialysis patients in these settings who are specifically trained in facilitating self management in renal patients.</p> <p>Trial registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRTN31434033">ISRTN31434033</a></p

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Not AvailableBased on the papers and proceedings of The National Workshop on Development of Inland Fishery Resources, sponsored by the Ministry of Agriculture, Govemment of India, and held during November 1 -3, 1983 at Ahmedabad under the joint auspices of the Centre for Management in Agriculture, Indian Institute of Management, Ahmedabad, and the Indian Society of Agricultural Economics, BombayNot Availabl