324 research outputs found
Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
<p>Abstract</p> <p>Background</p> <p>Previous studies have shown that administration of oxidized oils increases gene expression and activities of various enzymes involved in xenobiotic metabolism and stress response in the liver of rats and guinea pigs. As these genes are controlled by nuclear factor erythroid-derived 2-like 2 (Nrf2), we investigated the hypothesis that feeding of oxidized fats causes an activation of that transcription factor in the liver which in turn activates the expression of antioxidant, cytoprotective and detoxifying genes.</p> <p>Methods</p> <p>Twenty four crossbred pigs were allocated to two groups of 12 pigs each and fed nutritionally adequate diets with either fresh rapeseed oil (fresh fat group) or oxidized rapeseed oil prepared by heating at a temperature of 175°C for 72 h (oxidized fat group).</p> <p>Results</p> <p>After 29 days of feeding, pigs of the oxidized fat group had a markedly increased nuclear concentration of the transcription factor Nrf2 and a higher activity of cellular superoxide dismutase and T4-UDP glucuronosyltransferase in liver than the fresh fat group (<it>P </it>< 0.05). In addition, transcript levels of antioxidant and phase II genes in liver, like superoxide dismutase 1, heme oxygenase 1, glutathione peroxidase 1, thioredoxin reductase 1, microsomal glutathione-S-transferase 1, UDP glucuronosyltransferase 1A1 and NAD(P)H:quinone oxidoreductase 1 in the liver were higher in the oxidized fat group than in the fresh fat group (<it>P </it>< 0.05). Moreover, pigs of the oxidized fat group had an increased hepatic nuclear concentration of the transcription factor NF-κB which is also an important transcription factor mediating cellular stress response.</p> <p>Conclusion</p> <p>The present study shows for the first time that administration of an oxidized fat activates the Nrf2 in the liver of pigs which likely reflects an adaptive mechanism to prevent cellular oxidative damage. Activation of the NF-κB pathway might also contribute to this effect of oxidized fat.</p
Governing a shared hidden resource: A review of governance mechanisms for transboundary groundwater security
© 2017 Elsevier B.V. Globally, groundwater is by far the largest store of liquid freshwater, making it a key component of a secure water supply. However, over the past few decades the amount of usable groundwater available around the world has rapidly decreased. This depletion is caused primarily by mismanagement (e.g., overpumping, contamination, and under-regulation), but also by reduced natural recharge due to climate change and urbanization. Management of groundwater resources is particularly challenging for the nearly 600 aquifers that are transboundary, meaning that they extend across international political borders. To understand how governance mechanisms can reduce water insecurity in transboundary groundwater contexts, we review key literature from what we view as the most relevant fields: groundwater management, water security, international water law and international water governance. We then formulate a set of recommendations for improved groundwater governance that can address the specific physical nature of groundwater systems, enhance water security, and apply to transboundary groundwater settings. We argue that groundwater governance in transboundary contexts requires processes that (1) enhance context-specific and flexible international mechanisms; (2) address the perpetual need for groundwater data and information; (3) prioritize the precautionary principle and pollution prevention, in particular; (4) where appropriate, integrate governance of surface and subsurface water and land; and (5) expand institutional capacity, especially of binational or multinational actors
Impulsive phase flare energy transport by large-scale Alfven waves and the electron acceleration problem
The impulsive phase of a solar flare marks the epoch of rapid conversion of
energy stored in the pre-flare coronal magnetic field. Hard X-ray observations
imply that a substantial fraction of flare energy released during the impulsive
phase is converted to the kinetic energy of mildly relativistic electrons
(10-100 keV). The liberation of the magnetic free energy can occur as the
coronal magnetic field reconfigures and relaxes following reconnection. We
investigate a scenario in which products of the reconfiguration - large-scale
Alfven wave pulses - transport the energy and magnetic-field changes rapidly
through the corona to the lower atmosphere. This offers two possibilities for
electron acceleration. Firstly, in a coronal plasma with beta < m_e/m_p, the
waves propagate as inertial Alfven waves. In the presence of strong spatial
gradients, these generate field-aligned electric fields that can accelerate
electrons to energies on the order of 10 keV and above, including by repeated
interactions between electrons and wavefronts. Secondly, when they reflect and
mode-convert in the chromosphere, a cascade to high wavenumbers may develop.
This will also accelerate electrons by turbulence, in a medium with a locally
high electron number density. This concept, which bridges MHD-based and
particle-based views of a flare, provides an interpretation of the
recently-observed rapid variations of the line-of-sight component of the
photospheric magnetic field across the flare impulsive phase, and offers
solutions to some perplexing flare problems, such as the flare "number problem"
of finding and resupplying sufficient electrons to explain the impulsive-phase
hard X-ray emission.Comment: 31 pages, 6 figure
No effect of 24 h severe energy restriction on appetite regulation and ad libitum energy intake in overweight and obese males
Background/Objectives: Long-term success of weight loss diets might depend on how the appetite regulatory system responds to energy restriction (ER). This study determined the effect of 24 h severe ER on subjective and hormonal appetite regulation, subsequent ad libitum energy intake and metabolism.
Subjects/Methods: In randomised order, eight overweight or obese males consumed a 24 h diet containing either 100% (12105 (1174 kJ; energy balance; EB) or 25% (3039 (295) kJ; ER) of estimated daily energy requirements (EER). An individualised standard breakfast containing 25% of EER (3216 (341) kJ) was consumed the following morning and resting energy expenditure, substrate utilisation and plasma concentrations of acylated ghrelin, glucagon-like peptide-1 (GLP-17–36), glucose-dependant insulinotropic peptide (GIP1–42), glucose, insulin and non-esterified fatty acid (NEFA) were determined for 4 h after breakfast. Ad libitum energy intake was assessed in the laboratory on day 2 and via food records on day 3. Subjective appetite was assessed throughout.
Results: Energy intake was not different between trials for day 2 (EB: 14946 (1272) kJ; ER: 15251 (2114) kJ; P=0.623), day 3 (EB: 10580 (2457) kJ; 10812 (4357) kJ; P=0.832) or day 2 and 3 combined (P=0.693). Subjective appetite was increased during ER on day 1 (P0.381). Acylated ghrelin, GLP-17–36 and insulin were not different between trials (P>0.104). Post-breakfast area under the curve (AUC) for NEFA (P<0.05) and GIP1–42 (P<0.01) were greater during ER compared with EB. Fat oxidation was greater (P<0.01) and carbohydrate oxidation was lower (P<0.01) during ER, but energy expenditure was not different between trials (P=0.158).
Conclusions: These results suggest that 24 h severe ER does not affect appetite regulation or energy intake in the subsequent 48 h. This style of dieting may be conducive to maintenance of a negative EB by limiting compensatory eating behaviour, and therefore may assist with weight loss
The decline and rise of neighbourhoods: the importance of neighbourhood governance
There is a substantial literature on the explanation of neighbourhood change. Most of this literature concentrates on identifying factors and developments behind processes of decline. This paper reviews the literature, focusing on the identification of patterns of neighbourhood change, and argues that the concept of neighbourhood governance is a missing link in attempts to explain these patterns. Including neighbourhood governance in the explanations of neighbourhood change and decline will produce better explanatory models and, finally, a better view about what is actually steering neighbourhood change
New Insights into White-Light Flare Emission from Radiative-Hydrodynamic Modeling of a Chromospheric Condensation
(abridged) The heating mechanism at high densities during M dwarf flares is
poorly understood. Spectra of M dwarf flares in the optical and
near-ultraviolet wavelength regimes have revealed three continuum components
during the impulsive phase: 1) an energetically dominant blackbody component
with a color temperature of T 10,000 K in the blue-optical, 2) a smaller
amount of Balmer continuum emission in the near-ultraviolet at lambda 3646
Angstroms and 3) an apparent pseudo-continuum of blended high-order Balmer
lines. These properties are not reproduced by models that employ a typical
"solar-type" flare heating level in nonthermal electrons, and therefore our
understanding of these spectra is limited to a phenomenological interpretation.
We present a new 1D radiative-hydrodynamic model of an M dwarf flare from
precipitating nonthermal electrons with a large energy flux of erg
cm s. The simulation produces bright continuum emission from a
dense, hot chromospheric condensation. For the first time, the observed color
temperature and Balmer jump ratio are produced self-consistently in a
radiative-hydrodynamic flare model. We find that a T 10,000 K
blackbody-like continuum component and a small Balmer jump ratio result from
optically thick Balmer and Paschen recombination radiation, and thus the
properties of the flux spectrum are caused by blue light escaping over a larger
physical depth range compared to red and near-ultraviolet light. To model the
near-ultraviolet pseudo-continuum previously attributed to overlapping Balmer
lines, we include the extra Balmer continuum opacity from Landau-Zener
transitions that result from merged, high order energy levels of hydrogen in a
dense, partially ionized atmosphere. This reveals a new diagnostic of ambient
charge density in the densest regions of the atmosphere that are heated during
dMe and solar flares.Comment: 50 pages, 2 tables, 13 figures. Accepted for publication in the Solar
Physics Topical Issue, "Solar and Stellar Flares". Version 2 (June 22, 2015):
updated to include comments by Guest Editor. The final publication is
available at Springer via http://dx.doi.org/10.1007/s11207-015-0708-
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