Role of Nutrition in Alcoholic Liver Disease: Summary of the Symposium at the ESBRA 2017 Congress.

The symposium, "Role of Nutrition in Alcoholic Liver Disease", was held at the European Society for Biomedical Research on Alcoholism Congress on 9 October 2017 in Crete, Greece. The goal of the symposium was to highlight recent advances and developments in the field of alcohol and nutrition. The symposium was focused on experimental and clinical aspects in relation to the role of different types of dietary nutrients and malnutrition in the pathogenesis of alcoholic liver disease (ALD). The following is a summary of key research presented at this session. The speakers discussed the role of dietary fats and carbohydrates in the development and progression of alcohol-induced multi-organ pathology in animal models of ALD, analyzed novel nutrition-related therapeutics (specifically, betaine and zinc) in the treatment of ALD, and addressed clinical relevance of malnutrition and nutrition support in ALD. This summary of the symposium will benefit junior and senior faculty currently investigating alcohol-induced organ pathology as well as undergraduate, graduate, and post-graduate students and fellows

Effect of rhPDGF-BB on bone turnover during periodontal repair

Purpose : Growth factors such as platelet-derived growth factor (PDGF) exert potent effects on wound healing including the regeneration of periodontia. Pyridinoline cross-linked carboxyterminal telopeptide of type I collagen (ICTP) is a well-known biomarker of bone turnover, and as such is a potential indicator of osseous metabolic activity. The objective of this study was to evaluate the release of the ICTP into the periodontal wound fluid (WF) following periodontal reconstructive surgery using local delivery of highly purified recombinant human PDGF (rhPDGF)-BB. Methods : Forty-seven human subjects at five treatment centres possessing chronic severe periodontal disease were monitored longitudinally for 24 weeks following PDGF regenerative surgical treatment. Severe periodontal osseous defects were divided into one of three groups and treated at the time of surgery with either: Β -tricalcium phosphate (TCP) osteoconductive scaffold alone (active control), Β -TCP+0.3 mg/ml of rhPDGF-BB, or Β -TCP+1.0 mg/ml of rhPDGF-BB. WF was harvested and analysed for local ICTP levels by radioimmunoassay. Statistical analysis was performed using analysis of variance and an area under the curve analysis (AUC). Results : The 0.3 and 1.0 mg/ml PDGF-BB treatment groups demonstrated increases in the amount of ICTP released locally for up to 6 weeks. There were statistically significant differences at the week 6 time point between Β -TCP carrier alone group versus 0.3 mg/ml PDGF-BB group ( p <0.05) and between Β -TCP alone versus the 1.0 mg/ml PDGF-BB-treated lesions ( p <0.03). The AUC analysis revealed no statistical differences amongst groups. Conclusion : This study corroborates the release of ICTP as a measure of active bone turnover following local delivery of PDGF-BB to periodontal osseous defects. The amount of ICTP released from the WF revealed an early increase for all treatment groups. Data from this study suggests that when PDGF-BB is delivered to promote periodontal tissue engineering of tooth-supporting osseous defects, there is a direct effect on ICTP released from the wound.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72239/1/j.1600-051X.2005.00870.x.pd

Duality in Non-Trivially Compactified Heterotic Strings

We study the implications of duality symmetry on the analyticity properties of the partition function as it depends upon the compactification length. In order to obtain non-trivial compactifications, we give a physical prescription to get the Helmholtz free energy for any heterotic string supersymmetric or not. After proving that the free energy is always invariant under the duality transformation $R\rightarrow \alpha^{'}/(4R)$ and getting the zero temperature theory whose partition function corresponds to the Helmholtz potential, we show that the self-dual point $R_{0}=\sqrt{\alpha^{'}}/2$ is a generic singularity as the Hagedorn one. The main difference between these two critical compactification radii is that the term producing the singularity at the self-dual point is finite for any $R \neq R_{0}$. We see that this behavior at $R_{0}$ actually implies a loss of degrees of freedom below that point.Comment: (Preprint No. FTUAM-92/12) 17 page

Yang-Mills Theory as a Deformation of Topological Field Theory, Dimensional Reduction and Quark Confinement

We propose a reformulation of Yang-Mills theory as a perturbative deformation of a novel topological (quantum) field theory. We prove that this reformulation of the four-dimensional QCD leads to quark confinement in the sense of area law of the Wilson loop. First, Yang-Mills theory with a non-Abelian gauge group G is reformulated as a deformation of a novel topological field theory. Next, a special class of topological field theories is defined by both BRST and anti-BRST exact action corresponding to the maximal Abelian gauge leaving the maximal torus group H of G invariant. Then we find the topological field theory ($D>2$) has a hidden supersymmetry for a choice of maximal Abelian gauge. As a result, the D-dimensional topological field theory is equivalent to the (D-2)-dimensional coset G/H non-linear sigma model in the sense of Parisi and Sourlas dimensional reduction. After maximal Abelian gauge fixing, the topological property of magnetic monopole and anti-monopole of four-dimensional Yang-Mills theory is translated into that of instanton and anti-instanton in two-dimensional equivalent model. It is shown that the linear static potential in four-dimensions follows from the instanton--anti-instanton gas in the equivalent two-dimensional non-linear sigma model obtained from the four-dimensional topological field theory by dimensional reduction, while the remaining Coulomb potential comes from the perturbative part in four-dimensional Yang-Mills theory. The dimensional reduction opens a path for applying various exact methods developed in two-dimensional quantum field theory to study the non-perturbative problem in low-energy physics of four-dimensional quantum field theories.Comment: 58 pages, Latex, no figures, version accepted for publication in Phys. Rev. D (additions of Discussion, references and minor changes

Optical activity induced by curvature in a gravitational pp-wave background

We study optical activity induced by curvature. The optical activity model we present has two phenomenological gyration parameters, within which we analyze three model cases, namely, an exactly integrable model, the Landau-Lifshitz model and the Fedorov model, these latter two are solved in the short wavelength approximation. The model background is a gravitational pp-wave. The solutions show that the optical activity induced by curvature leads to Faraday rotation.Comment: 16 pages, late

Platelet‐Derived Growth Factor Stimulates Bone Fill and Rate of Attachment Level Gain: Results of a Large Multicenter Randomized Controlled Trial

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141430/1/jper2205.pd

Platelet‐Derived Growth Factor Promotes Periodontal Regeneration in Localized Osseous Defects: 36‐Month Extension Results From a Randomized, Controlled, Double‐Masked Clinical Trial

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141092/1/jper0456.pd

SeaWiFS technical report series. Volume 19: Case studies for SeaWiFS calibration and validation, part 2

This document provides brief reports, or case studies, on a number of investigations and data set development activities sponsored by the Calibration and Validation Team (CVT) within the Sea-viewing Wide Field-of-view Sensor (SeaWiFS) Project. Chapter 1 is a comparison with the atmospheric correction of Coastal Zone Color Scanner (CZCS) data using two independent radiative transfer formulations. Chapter 2 is a study on lunar reflectance at the SeaWiFS wavelengths which was useful in establishing the SeaWiFS lunar gain. Chapter 3 reports the results of the first ground-based solar calibration of the SeaWiFS instrument. The experiment was repeated in the fall of 1993 after the instrument was modified to reduce stray light; the results from the second experiment will be provided in the next case studies volume. Chapter 4 is a laboratory experiment using trap detectors which may be useful tools in the calibration round-robin program. Chapter 5 is the original data format evaluation study conducted in 1992 which outlines the technical criteria used in considering three candidate formats, the hierarchical data format (HDF), the common data format (CDF), and the network CDF (netCDF). Chapter 6 summarizes the meteorological data sets accumulated during the first three years of CZCS operation which are being used for initial testing of the operational SeaWiFS algorithms and systems and would be used during a second global processing of the CZCS data set. Chapter 7 describes how near-real time surface meteorological and total ozone data required for the atmospheric correction algorithm will be retrieved and processed. Finally, Chapter 8 is a comparison of surface wind products from various operational meteorological centers and field observations. Surface winds are used in the atmospheric correction scheme to estimate glint and foam radiances

Thermodynamic behavior of IIA string theory on a pp-wave

We obtain the thermal one loop free energy and the Hagedorn temperature of IIA superstring theory on the pp-wave geometry which comes from the circle compactification of the maximally supersymmetric eleven dimensional one. We use both operator and path integral methods and find the complete agreement between them in the free energy expression. In particular, the free energy in the $\mu \to \infty$ limit is shown to be identical with that of IIB string theory on maximally supersymmetric pp-wave, which indicates the universal thermal behavior of strings in the large class of pp-wave backgrounds. We show that the zero point energy and the modular properties of the free energy are naturally incorporated into the path integral formalism.Comment: 25 pages, Latex, JHEP style, v4: revised for clarity without change in main contents, version to appear in JHE