End of a Dark Age?

We argue that dark matter and dark energy phenomena associated with galactic rotation curves, X-ray cluster mass profiles, and type Ia supernova data can be accounted for via small corrections to idealized general relativistic spacetime geometries due to disordered locality. Accordingly, we fit THINGS rotation curve data rivaling modified Newtonian dynamics, ROSAT/ASCA X-ray cluster mass profile data rivaling metric-skew-tensor gravity, and SCP Union2.1 SN Ia data rivaling $\Lambda$CDM without non-baryonic dark matter or a cosmological constant. In the case of dark matter, we geometrically modify proper mass interior to the Schwarzschild solution. In the case of dark energy, we modify proper distance in Einstein-deSitter cosmology. Therefore, the phenomena of dark matter and dark energy may be chimeras created by an errant belief that spacetime is a differentiable manifold rather than a disordered graph.Comment: This version was accepted for publication in the International Journal of Modern Physics D; revised version of an essay that won Honorable Mention in the Gravity Research Foundation 2016 Awards for Essays on Gravitation. 10 pages, 3 figures. arXiv admin note: text overlap with arXiv:1509.0928

The Missing Mass Problem as a Manifestation of GR Contextuality

In Newtonian gravity, mass is an intrinsic property of matter while in general relativity (GR), mass is a contextual property of matter, i.e., matter can simultaneously possess two different values of mass when it is responsible for two different spatiotemporal geometries. Herein, we explore the possibility that the astrophysical missing mass attributed to non-baryonic dark matter (DM) actually obtains because we have been assuming the Newtonian view of mass rather than the GR view. Since an exact GR solution for realistic astrophysical situations is not feasible, we explore GR-motivated ansatzes relating proper mass and dynamic mass for one and the same baryonic matter, as justified by GR contextuality. We consider four GR alternatives and find that the GR ansatz motivated by metric perturbation theory works well in fitting galactic rotation curves (THINGS data), the mass profiles of X-ray clusters (ROSAT and ASCA data) and the angular power spectrum of the cosmic microwave background (CMB, Planck 2015 data) without DM. We compare our galactic rotation curve fits to modified Newtonian dynamics (MOND), Burkett halo DM and Navarro-Frenk-White (NFW) halo DM. We compare our X-ray cluster mass profile fits to metric skew-tensor gravity (MSTG) and core-modified NFW DM. We compare our CMB angular power spectrum fit to scalar-tensor-vector gravity (STVG) and $\Lambda$CDM. Overall, we find our fits to be comparable to those of MOND, MSTG, STVG, $\Lambda$CDM, Burkett, and NFW. We present and discuss correlations and trends for the best fit values of our fitting parameters. For the most part, the correlations are consistent with well-established results at all scales, which is perhaps surprising given the simple functional form of the GR ansatz.Comment: 18 pages text. Twice revised per referee/reviewer comments. Fit of CMB angular power spectrum and dark matter halo fits adde

Measuring subdiffusion parameters

We propose a method to extract from experimental data the subdiffusion parameter $\alpha$ and subdiffusion coefficient $D_\alpha$ which are defined by means of the relation $=2D_\alpha/\Gamma(1+\alpha) t^\alpha$ where $$ denotes a mean square displacement of a random walker starting from $x=0$ at the initial time $t=0$. The method exploits a membrane system where a substance of interest is transported in a solvent from one vessel to another across a thin membrane which plays here only an auxiliary role. Using such a system, we experimentally study a diffusion of glucose and sucrose in a gel solvent. We find a fully analytic solution of the fractional subdiffusion equation with the initial and boundary conditions representing the system under study. Confronting the experimental data with the derived formulas, we show a subdiffusive character of the sugar transport in gel solvent. We precisely determine the parameter $\alpha$, which is smaller than 1, and the subdiffusion coefficient $D_\alpha$.Comment: 17 pages, 9 figures, revised, to appear in Phys. Rev.

Development of an e-learning portal for pediatric endocrinology: educational considerations

Background: Global accessibility and dissemination of developments in pediatric endocrinology prompted to examine how to develop an educational interactive e-SPE web portal. Methods: A systematic approach was used to identify the relevant aspects of accessibility and dissemination. An orientation at the big idea was made, executed by an analysis of the needs of student and teacher pediatric endocrinologists, a definition of the learning objectives, a research in educational literature and an exploration of ICT design specifications. Results: The intensive collaboration between medical, educational and information technology disciplines resulted in a portal design. The portal meets requirements of adult learning, stresses interaction between partners in learning and offers direct feedback during the learning process. The portal supports the development of not only knowledge but also competences both at junior and advanced levels. Conclusion: When the e-SPE portal is completed, the options for summative assessment will be examined as a medium for international certification in conjunction with local and national requirements (http://espe.elearning.nl). Copyrigh

The tectum/superior colliculus as the vertebrate solution for spatial sensory integration and action

The superior colliculus, or tectum in the case of non-mammalian vertebrates, is a part of the brain that registers events in the surrounding space, often through vision and hearing, but also through electrosensation, infrared detection, and other sensory modalities in diverse vertebrate lineages. This information is used to form maps of the surrounding space and the positions of different salient stimuli in relation to the individual. The sensory maps are arranged in layers with visual input in the uppermost layer, other senses in deeper positions, and a spatially aligned motor map in the deepest layer. Here, we will review the organization and intrinsic function of the tectum/superior colliculus and the information that is processed within tectal circuits. We will also discuss tectal/superior colliculus outputs that are conveyed directly to downstream motor circuits or via the thalamus to cortical areas to control various aspects of behavior. The tectum/superior colliculus is evolutionarily conserved among all vertebrates, but tailored to the sensory specialties of each lineage, and its roles have shifted with the emergence of the cerebral cortex in mammals. We will illustrate both the conserved and divergent properties of the tectum/superior colliculus through vertebrate evolution by comparing tectal processing in lampreys belonging to the oldest group of extant vertebrates, larval zebrafish, rodents, and other vertebrates including primates