258 research outputs found
Auricular Oedema and Dyshidrotic Eczema in a Patient with Acute Myeloid Leukaemia Treated with Cytarabine
Cytarabine is an effective drug in the treatment of haematological malignancies. The therapy is associated with various complications. Frequencies of dermatological side-effects range from 2–72% and occur most commonly after high-dose regimens. Although most cutaneous reactions are mild and resolve spontaneously within several days, they may result in an increased risk of infection and alterations in comfort. In some cases, severe life-threatening reactions have been reported. Here we describe the case of a patient with acute myeloid leukaemia, who developed severe exceptional skin toxicity in terms of auricular oedema and palmar dyshidrotic eczema after the application of low-dose cytarabine. Re-administration of the drug resulted in reduced skin toxicity during further cycles of chemotherapy. Negative epicutaneous patch-testing supported the existence of cytarabine-provoked toxicity
Differential Effects of Comorbid Psychiatric Disorders on Treatment Outcome in Posttraumatic Stress Disorder from Childhood Trauma
Differential Effects of Comorbid Psychiatric Disorders on Treatment Outcome in Posttraumatic Stress Disorder from Childhood Trauma
PRO*BPD: effectiveness of outpatient treatment programs for borderline personality disorder: a comparison of Schema therapy and dialectical behavior therapy: study protocol for a randomized trial
Collective Modes of Soliton-Lattice States in Double-Quantum-Well Systems
In strong perpendicular magnetic fields double-quantum-well systems can
sometimes occur in unusual broken symmetry states which have interwell phase
coherence in the absence of interwell hopping. When hopping is present in such
systems and the magnetic field is tilted away from the normal to the quantum
well planes, a related soliton-lattice state can occur which has kinks in the
dependence of the relative phase between electrons in opposite layers on the
coordinate perpendicular to the in-plane component of the magnetic field. In
this article we evaluate the collective modes of this soliton-lattice state in
the generalized random-phase aproximation. We find that, in addition to the
Goldstone modes associated with the broken translational symmetry of the
soliton-lattice state, higher energy collective modes occur which are closely
related to the Goldstone modes present in the spontaneously phase-coherent
state. We study the evolution of these collective modes as a function of the
strength of the in-plane magnetic field and comment on the possibility of using
the in-plane field to generate a finite wave probe of the spontaneously
phase-coherent state.Comment: REVTEX, 37 pages (text) and 15 uuencoded postscript figure
A microfluidic platform for the characterisation of membrane active antimicrobials.
The spread of bacterial resistance against conventional antibiotics generates a great need for the discovery of novel antimicrobials. Polypeptide antibiotics constitute a promising class of antimicrobial agents that favour attack on bacterial membranes. However, efficient measurement platforms for evaluating their mechanisms of action in a systematic manner are lacking. Here we report an integrated lab-on-a-chip multilayer microfluidic platform to quantify the membranolytic efficacy of such antibiotics. The platform is a biomimetic vesicle-based screening assay, which generates giant unilamellar vesicles (GUVs) in physiologically relevant buffers on demand. Hundreds of these GUVs are individually immobilised downstream in physical traps connected to separate perfusion inlets that facilitate controlled antibiotic delivery. Antibiotic efficacy is expressed as a function of the time needed for an encapsulated dye to leak out of the GUVs as a result of antibiotic treatment. This proof-of-principle study probes the dose response of an archetypal polypeptide antibiotic cecropin B on GUVs mimicking bacterial membranes. The results of the study provide a foundation for engineering quantitative, high-throughput microfluidics devices for screening antibiotics.-Trinity College, University of Cambridge (Trinity-Henry Barlow Scholarship)
-H2020 European Research Council Advanced grants SynDiv (no. 669598), Consolidator Grant Designer- Pores (no. 647144)
-Nederlandse Organisatie voor Wetenschappelijk Onderzoek Frontiers of Nanoscience program
-Winton Programme for the Physics of Sustainability
-Biotechnology and Biological Sciences Research Council
-Friedrich-Naumann-Foundation
-National Physical Laboratory EPSRC CASE
-Department for Business, Energy & Industrial Strategy
-European Metrology Research Programme (EMRP
The transition from the adiabatic to the sudden limit in core level photoemission: A model study of a localized system
We consider core electron photoemission in a localized system, where there is
a charge transfer excitation. The system is modelled by three electron levels,
one core level and two outer levels. The model has a Coulomb interaction
between these levels and the continuum states into which the core electron is
emitted. The model is simple enough to allow an exact numerical solution, and
with a separable potential an analytic solution. We calculate the ratio
r(omega) between the weights of the satellite and the main peak as a function
of the photon energy omega. The transition from the adiabatic to the sudden
limit takes place for quite small photoelectron kinetic energies. For such
small energies, the variation of the dipole matrix element is substantial and
described by the energy scale Ed. Without the coupling to the photoelectron,
the corresponding ratio r0(omega) is determined by Ed and the satellite
excitation energy dE. When the interaction potential with the continuum states
is introduced, a new energy scale Es=1/(2Rs^2) enters, where Rs is a length
scale of the interaction potential. At threshold there is typically a (weak)
constructive interference between intrinsic and extrinsic contributions, and
the ratio r(omega)/r0(omega) is larger than its limiting value for large omega.
The interference becomes small or weakly destructive for photoelectron energies
of the order Es. For larger energies r(omega)/r0(omega) therefore typically has
a weak undershoot. If this undershoot is neglected, r(omega)/r0(omega) reaches
its limiting value on the energy scale Es.Comment: 18 pages, latex2e, 13 eps figure
Stealth dark matter confinement transition and gravitational waves
We use non-perturbative lattice calculations to investigate the finite-temperature confinement transition of stealth dark matter, focusing on the regime in which this early-universe transition is first order and would generate a stochastic background of gravitational waves. Stealth dark matter extends the standard model with a new strongly coupled SU(4) gauge sector with four massive fermions in the fundamental representation, producing a stable spin-0 'dark baryon' as a viable composite dark matter candidate. Future searches for stochastic gravitational waves will provide a new way to discover or constrain stealth dark matter, in addition to previously investigated direct-detection and collider experiments. As a first step to enabling this phenomenology, we determine how heavy the dark fermions need to be in order to produce a first-order stealth dark matter confinement transition
Near-conformal dynamics in a chirally broken system
Composite Higgs models must exhibit very different dynamics from quantum chromodynamics (QCD) regardless whether they describe the Higgs boson as a dilatonlike state or a pseudo-Nambu-Goldstone boson. Large separation of scales and large anomalous dimensions are frequently desired by phenom- enological models. Mass-split systems are well-suited for composite Higgs models because they are governed by a conformal fixed point in the ultraviolet but are chirally broken in the infrared. In this work we use lattice field theory calculations with domain wall fermions to investigate a system with four light and six heavy flavors. We demonstrate how a nearby conformal fixed point affects the properties of the four light flavors that exhibit chiral symmetry breaking in the infrared. Specifically we describe hyperscaling of dimensionful physical quantities and determine the corresponding anomalous mass dimension. We obtain ym = 1 + γ* = 1.47(5) suggesting that Nf = 10 lies inside the conformal window. Comparing the low energy spectrum to predictions of dilaton chiral perturbation theory, we observe excellent agreement which supports the expectation that the 4+6 mass-split system exhibits near-conformal dynamics with a relatively light 0þþ isosinglet scalar
Near-conformal dynamics in a chirally broken system
Composite Higgs models must exhibit very different dynamics from quantum chromodynamics (QCD) regardless whether they describe the Higgs boson as a dilaton-like state or a pseudo-Nambu-Goldstone boson. Large separation of scales and large anomalous dimensions are frequently desired by phenomenological models. Mass-split systems are well-suited for composite Higgs models because they are governed by a conformal fixed point in the ultraviolet but are chirally broken in the infrared. In this work we use lattice field theory calculations with domain wall fermions to investigate a system with four light and six heavy flavors. We demonstrate how a nearby conformal fixed point affects the properties of the four light flavors that exhibit chiral symmetry breaking in the infrared. Specifically we describe hyperscaling of dimensionful physical quantities and determine the corresponding anomalous mass dimension. We obtain suggesting that lies inside the conformal window. Comparing the low energy spectrum to predictions of dilaton chiral perturbation theory, we observe excellent agreement which supports the expectation that the 4+6 mass-split system exhibits near-conformal dynamics with a relatively light isosinglet scalar
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