157 research outputs found
Effect of Increased Doses of Zinc and Copper on the Activity of Liver Monooxygenase System in Chronic Experimental Carbon Disulfide Intoxication
Addressing optimal folate and related B vitamin status through the lifecycle: health impacts and challenges
MTHFR 677TT genotype and disease risk: is there a modulating role for B-vitamins?
Methylenetetrahydrofolate reductase (MTHFR) is a critical folate-metabolising enzyme which requires riboflavin as its co-factor. A common polymorphism (677CāT) in theMTHFRgene results in reduced MTHFR activityin vivowhich in turn leads to impaired folate metabolism and elevated homocysteine concentrations. Homozygosity for this polymorphism (TT genotype) is associated with an increased risk of a number of conditions including heart disease and stroke, but there is considerable variability in the extent of excess risk in various reports. The present review will explore the evidence which supports a role for this polymorphism as a risk factor for a number of adverse health outcomes, and the potential modulating roles for B-vitamins in alleviating disease risk. The evidence is convincing in the case which links this polymorphism with hypertension and hypertensive disorders of pregnancy, particularly preeclampsia. Furthermore, elevated blood pressure was found to be highly responsive to riboflavin intervention specifically in individuals with theMTHFR677TT genotype. Future intervention studies targeted at these genetically predisposed individuals are required to further investigate this novel geneānutrient interaction. This polymorphism has also been associated with an increased risk of neural tube defects (NTD) and other adverse pregnancy outcomes; however, the evidence in this area has been inconsistent. Preliminary evidence has suggested that there may be a much greater need for women with theMTHFR677TT genotype to adhere to the specific recommendation of commencing folic acid prior to conception for the prevention of NTD, but this requires further investigation.</jats:p
Assessment of candidate folate sensitive-differentially methylated regions in a randomised controlled trial of continued folic acid supplementation during the second and third trimesters of pregnancy
CandiMeth: Powerful yet simple visualization and quantification of DNA methylation at candidate genes
MenaQ7 (R) and maintenance of the elastic properties of the arteries: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006
Peer reviewedPublisher PD
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