11 research outputs found
Structural-Functional of the Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1
Backround: The molecular mechanisms underlying activation of CRF1 receptor (CRF1R) were elusive.
Results: We determined specific residues in the transmembrane domains (TMs) of CRF1R that are critical for receptor
activation.
Conclusion: A possible “transmission switch” involving TM interactions is important for CRF1R activation.
Significance: This knowledge may aid in the development of nonpeptide CRF1R antagonists for use in stress-related disorder
Trimethylsulfonium Lead Triiodide: An Air-Stable Hybrid Halide Perovskite
We
report on the synthesis, characterization, and optoelectronic properties
of the novel trimethylsulfonium lead triiodide perovskite, (CH<sub>3</sub>)<sub>3</sub>SPbI<sub>3</sub>. At room temperature, the air-stable
compound adopts a hexagonal crystal structure with a 1D network of
face-sharing [PbI<sub>6</sub>] octahedra along the <i>c</i> axis. UV–vis reflectance spectroscopy on a pressed pellet
revealed a band gap of 3.1 eV, in agreement with first-principles
calculations, which show a small separation between direct and indirect
band gaps. Electrical resistivity measurements on single crystals
indicated that the compound behaves as a semiconductor. According
to multi-temperature single-crystal X-ray diffraction, synchrotron
powder X-ray diffraction, Raman spectroscopy, and differential scanning
calorimetry, two fully reversible structural phase transitions occur
at −5 and ca. −100 °C with reduction of the unit
cell symmetry to monoclinic as temperature decreases. The role of
the trimethylsulfonium cation regarding the chemical stability and
optoelectronic properties of the new compound is discussed in comparison
with APbI<sub>3</sub> (A = Cs, methylammonium, and formamidinium cation),
which are most commonly used in perovskite solar cells