A theory of new type of heavy-electron superconductivity in PrOs_4Sb_12: quadrupolar-fluctuation mediated odd-parity pairings

It is shown that unconventional nature of superconducting state of PrOs_4Sb_12, a Pr-based heavy electron compound with the filled-Skutterudite structure, can be explained in a unified way by taking into account the structure of the crystalline-electric-field (CEF) level, the shape of the Fermi surface determined by the band structure calculation, and a picture of the quasiparticles in f$^{2}$-configuration with magnetically singlet CEF ground state. Possible types of pairing are narrowed down by consulting recent experimental results. In particular, the chiral "p"-wave states such as p_x+ip_y is favoured under the magnetic field due to the orbital Zeeman effect, while the "p"-wave states with two-fold symmetery such as p_x can be stabilized by a feedback effect without the magnetic field. It is also discussed that the double superconducting transition without the magnetic field is possible due to the spin-orbit coupling of the "triplet" Cooper pairs in the chiral state.Comment: 12 pages, 2 figures, submitted to J. Phys.: Condens. Matter Lette

Organization of multiprotein complexes at cell–cell junctions

The formation of stable cell–cell contacts is required for the generation of barrier-forming sheets of epithelial and endothelial cells. During various physiological processes like tissue development, wound healing or tumorigenesis, cellular junctions are reorganized to allow the release or the incorporation of individual cells. Cell–cell contact formation is regulated by multiprotein complexes which are localized at specific structures along the lateral cell junctions like the tight junctions and adherens junctions and which are targeted to these site through their association with cell adhesion molecules. Recent evidence indicates that several major protein complexes exist which have distinct functions during junction formation. However, this evidence also indicates that their composition is dynamic and subject to changes depending on the state of junction maturation. Thus, cell–cell contact formation and integrity is regulated by a complex network of protein complexes. Imbalancing this network by oncogenic proteins or pathogens results in barrier breakdown and eventually in cancer. Here, I will review the molecular organization of the major multiprotein complexes at junctions of epithelial cells and discuss their function in cell–cell contact formation and maintenance

Formin homology 2 domains occur in multiple contexts in angiosperms

BACKGROUND: Involvement of conservative molecular modules and cellular mechanisms in the widely diversified processes of eukaryotic cell morphogenesis leads to the intriguing question: how do similar proteins contribute to dissimilar morphogenetic outputs. Formins (FH2 proteins) play a central part in the control of actin organization and dynamics, providing a good example of evolutionarily versatile use of a conserved protein domain in the context of a variety of lineage-specific structural and signalling interactions. RESULTS: In order to identify possible plant-specific sequence features within the FH2 protein family, we performed a detailed analysis of angiosperm formin-related sequences available in public databases, with particular focus on the complete Arabidopsis genome and the nearly finished rice genome sequence. This has led to revision of the current annotation of half of the 22 Arabidopsis formin-related genes. Comparative analysis of the two plant genomes revealed a good conservation of the previously described two subfamilies of plant formins (Class I and Class II), as well as several subfamilies within them that appear to predate the separation of monocot and dicot plants. Moreover, a number of plant Class II formins share an additional conserved domain, related to the protein phosphatase/tensin/auxilin fold. However, considerable inter-species variability sets limits to generalization of any functional conclusions reached on a single species such as Arabidopsis. CONCLUSIONS: The plant-specific domain context of the conserved FH2 domain, as well as plant-specific features of the domain itself, may reflect distinct functional requirements in plant cells. The variability of formin structures found in plants far exceeds that known from both fungi and metazoans, suggesting a possible contribution of FH2 proteins in the evolution of the plant type of multicellularity

Comparative Live-Cell Imaging Analyses of SPA-2, BUD-6 and BNI-1 in Neurospora crassa Reveal Novel Features of the Filamentous Fungal Polarisome

A key multiprotein complex involved in regulating the actin cytoskeleton and secretory machinery required for polarized growth in fungi, is the polarisome. Recognized core constituents in budding yeast are the proteins Spa2, Pea2, Aip3/Bud6, and the key effector Bni1. Multicellular fungi display a more complex polarized morphogenesis than yeasts, suggesting that the filamentous fungal polarisome might fulfill additional functions. In this study, we compared the subcellular organization and dynamics of the putative polarisome components BUD-6 and BNI-1 with those of the bona fide polarisome marker SPA-2 at various developmental stages of Neurospora crassa. All three proteins exhibited a yeast-like polarisome configuration during polarized germ tube growth, cell fusion, septal pore plugging and tip repolarization. However, the localization patterns of all three proteins showed spatiotemporally distinct characteristics during the establishment of new polar axes, septum formation and cytokinesis, and maintained hyphal tip growth. Most notably, in vegetative hyphal tips BUD-6 accumulated as a subapical cloud excluded from the Spitzenkörper (Spk), whereas BNI-1 and SPA-2 partially colocalized with the Spk and the tip apex. Novel roles during septal plugging and cytokinesis, connected to the reinitiation of tip growth upon physical injury and conidial maturation, were identified for BUD-6 and BNI-1, respectively. Phenotypic analyses of gene deletion mutants revealed additional functions for BUD-6 and BNI-1 in cell fusion regulation, and the maintenance of Spk integrity. Considered together, our findings reveal novel polarisome-independent functions of BUD-6 and BNI-1 in Neurospora, but also suggest that all three proteins cooperate at plugged septal pores, and their complex arrangement within the apical dome of mature hypha might represent a novel aspect of filamentous fungal polarisome architecture

ABCC5, a Gene That Influences the Anterior Chamber Depth, Is Associated with Primary Angle Closure Glaucoma

Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size = -0.045 mm, P = 8.17×10-9). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45×10-9; 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions

Pulse duration dependence of opacity effects in Ni-like W TCE X-ray lasers

A compact simulation code is modified and used to investigate the effects of opacity on the 4.3-nm nickellike tungsten soft-x-ray laser, which includes the change in the escape factor with time. Result shows that the maximum gain depends only weakly on the opacity and the pump pulse duration below 1-ps. The above results predict that a 1-ps, 4-joule KrF laser pulse is sufficient for the saturated operation of the 4.3-nm laser, and that special methods to decrease opacity effects are not necessary

Jetlike visible emission from preplasma pumped by a longitudinal picosecond laser pulse

We report on the observation of jetlike visible emission from molybdenum plasma, which is pumped by a high-intensity 2-ps-duration Nd : phosphate glass laser pulse. These jets are found to extend over an unusually long length of several millimeters. The structure appears only at longitudinal pump intensities between 5x1014 W/cm2 and 7.5x1014 W/cm2, and the temporal duration of the jetlike emission is measured to be 500 ns

Propagation of picosecond Nd : glass laser pulse through molybdenum preplasma

We experimentally investigate the interaction of a high intensity 2-ps Nd : Glass laser pulse with preformed plasma, relevant to longitudinally-pumped transient-collisional-excitation x-ray lasers. The transverse intensity profile of the longitudinal beam after propagation through molybdenum preplasma is experimentally observed. The experimental results are found to be well reproduced by simple hydrodynarnic and ray-tracing calculations, if the nonuniform intensity distribution along the line-focus is taken into account