41 research outputs found
Single breath-hold non-contrast thoracic mra using highly-accelerated parallel imaging with a 32-element coil array
Highly accelerated single breath-hold non-contrast thoracic MRA: evaluation in a clinical population
Single breath-hold non-contrast thoracic mra using highly-accelerated parallel imaging with a 32-element coil array
Verwijzen naar het hospice: verwijsgedrag van artsen en ervaren belemmeringen in Deventer en omgeving
Kinesin and Myosin Motors Compete to Drive Rich Multi-Phase Dynamics in Programmable Cytoskeletal Composites
The cytoskeleton of biological cells relies on a diverse population of
motors, filaments, and binding proteins acting in concert to enable
non-equilibrium processes ranging from mitosis to chemotaxis. The
cytoskeleton's versatile reconfigurability, programmed by interactions between
its constituents, make it a foundational active matter platform. However,
current active matter endeavors are limited largely to single force-generating
components acting on a single substrate - far from the composite cytoskeleton
in live cells. Here, we engineer actin-microtubule composites, driven by
kinesin and myosin motors and tuned by crosslinkers, that restructure into
diverse morphologies from interpenetrating filamentous networks to de-mixed
amorphous clusters. Our Fourier analyses reveal that kinesin and myosin compete
to delay kinesin-driven restructuring and suppress de-mixing and flow, while
crosslinking accelerates reorganization and promotes actin-microtubule
correlations. The phase space of non-equilibrium dynamics falls into three
broad classes - slow reconfiguration, fast advective flow, and multi-mode
ballistic dynamics - with structure-dynamics relations described by the
relative contributions of elastic and dissipative responses to motor-generated
strain