15 research outputs found
Ectopia cordis about a case at Ourossogui regional hospital center
We report in this work, an extremely rare and major case of anterior body wall defects included ectopia cordis define by abnormal location of heart outside of the thorax. This case was diagnosed at the maternity of Ourossogui regional hospital center, in Senegal. Any scan was performed during the pregnancy. Newborn died 10 minutes after birth. Ectopia cordis is related to a possible ventral midline developmental abnormality. Itâs associated to other midline abnormalities and is a part of pentalogy of Cantrell. An X-linked genetic abnormality
Apport de la scintigraphie renale dans lâexploration dâun syndrome de jonction pyelo ureterale sur rein ectopique revele par une pyelonephrite gravidique a propos dâun cas.
Le syndrome de jonction pyelo-urĂ©tĂ©rale est une uropathie malformative de diagnostic antĂ©natal de nos jours notamment dans les pays dĂ©veloppĂ©s. Nous rapportons un cas associĂ© Ă une ectopie rĂ©nale iliaque gauche rĂ©vĂ©lĂ© par une pyĂ©lonĂ©phrite avec pyonephrose chez une gestante de 26 ans. Lâexploration en imagerie a Ă©tĂ© faite Ă lâĂ©chographie et Ă la scintigraphie rĂ©nale dynamique au DTPA-99mTc et statique au DMSA-99mTc. Lâexploration scintigraphique a Ă©tĂ© dĂ©terminante dans lâorientation thĂ©rapeutique qui a Ă©tĂ© sanctionnĂ©e par une nĂ©phrectomie gauche. Les aspects Ă©tiopathogĂ©niques et la place de lâimagerie mĂ©dicale notamment de la scintigraphie aussi bien dans la prise en charge diagnostique que thĂ©rapeutique sont discutĂ©es Ă la lumiĂšre de la littĂ©rature.Mots clĂ©s : Syndrome de jonction pyĂ©lo-urĂ©terale, ectopie rĂ©nale, Scintigraphie rĂ©nale, pays en dĂ©veloppement
The association of intraprostatic calcifications and dosimetry parameters with biochemical control after permanent prostate implant
Purpose: The objective of this study was to evaluate the impact of intraprostatic calcifications (IC) on long-term tumor control in patients treated with permanent implant prostate brachytherapy (PIPB). Materials and Methods: Data from 609 I-125 patients treated with PIPB were retrospectively reviewed. The presence of IC was determined by reviewing postimplant CT images. Doses delivered were determined using the Monte Carlo (model-based) calculations and the TG43 approach. Biochemical relapses at 7 and 10 years were determined according to Phoenix definition. Long-term biochemical relapse-free survival (bRFS) was determined using KaplanâMeier estimates with log rank test. Cox proportional hazard models were used for analysis of predictor factors of biochemical recurrence. Results: IC were observed for 11.1% of patients. Clinical stage, PSA, Gleason score, D'Amico risk group, and ADT use were comparable between IC and no IC groups. The 7- and 10-year bRFS for the entire cohort were 94.1% and 90.6%, respectively. The bRFS at 7 years was 90.5% (with IC) vs. 94.5% (without IC) (p = 0.198); the corresponding values at 10 years were 78.8% vs. 91.8% (p = 0.046). On Cox model, only prostatic calcifications were a significant risk factor for biochemical relapse (HR: 2.30, IC 95%: 1.05â5.00, p = 0.037; and HR: 3.94; IC 95%: 1.00â15.38; p = 0.049 for univariate and multivariate analysis, respectively). Conclusion: The presence of IC in patients treated with PIPB decreases V100 and D90 for postimplant Monte Carlo dosimetry (compared with TG43); correspondingly, IC are associated with a lower 10-y bRFS. Model-based dose calculations are critical to evaluate potential cold spots due to calcifications
Addition of Berberine to 5-Aminosalicylic Acid for Treatment of Dextran Sulfate Sodium-Induced Chronic Colitis in C57BL/6 Mice.
Ulcerative colitis (UC) is a common chronic remitting disease but without satisfactory treatment. Alternative medicine berberine has received massive attention for its potential in UC treatment. Conventional therapies with the addition of berberine are becoming attractive as novel therapies in UC. In the present study, we investigated the preclinical activity of a conventional oral 5-aminosalicylic acid (5-ASA) therapy plus berberine in experimental colitis. A subclinical dose of 5-ASA (200 mg/kg/day) alone or 5-ASA plus berberine (20 mg/kg/day) was orally administered for 30 days to C57BL/6 mice with colitis induced by three cycles of 2% dextran sulfate sodium (DSS). The disease severity, inflammatory responses, drug accumulation and potential toxicity of colitis mice were examined. The results showed that comparing to 5-ASA alone, 5-ASA plus berberine more potently ameliorated DSS-induced disease severity, colon shortening, and colon histological injury. Further, the up-regulation in mRNA level of colonic TNF-α as well as NFÎșB and JAK2 phosphorylation caused by DSS were more pronouncedly reversed in animals treated with the combination therapy than those treated with 5-ASA alone. Moreover, the addition of berberine to 5-ASA more significantly inhibited lymphocyte TNF-α secretion of DSS mice than 5-ASA alone. In the meanwhile, no extra drug accumulation or potential toxicity to major organs of colitis mice was observed with this combination treatment. In summary, our studies provide preclinical rationale for the addition of berberine to 5-ASA as a promising therapeutic strategy in clinic by reducing dose of standard therapy
Silica-Coated and Bare Akaganeite Nanorods: Structural and Magnetic Properties
We
report on structural and magnetic properties of uniform silica-coated
akaganeite nanorods with length of <i>L</i> ⌠80
± 15 nm and diameter <i>D</i> ⌠15 ± 5
nm as well as silica shell thickness of about 5 nm. Unexpected negative
difference between field-cooled (FC) and zero-field-cooled (ZFC) magnetization
Î<i>M</i> = <i>M</i><sub>FC</sub> â <i>M</i><sub>ZFC</sub> < 0, room temperature ferromagnetism,
and exchange bias effect have been found. The nanorods are investigated
by X-ray powder diffraction (XRPD), transmission electron microscopy
(TEM), and vibrating sample magnetometer (VSM) measurements. The magnetic
measurements were also performed on bare akaganeite nanorods in order
to discriminate the effects of silica coating on the magnetic properties.
The measured coercivity and exchange bias effect of bare ÎČ-FeOOH
nanorods are much lower compared with same properties of SiO<sub>2</sub>@ÎČ-FeOOH nanorods, emphasizing the effect of silica coating
on the magnetic properties. These results are discussed considering
the coreâshell structure of akaganeite nanorods; i.e., the
inner part of the akaganeite nanorod has antiferromagnetic ordering,
whereas the nanorod surface exhibits some disorder spin state