X-raying the coronae of HD~155555

We present an analysis of the high-resolution Chandra observation of the multiple system, HD 155555 (an RS CVn type binary system, HD 155555 AB, and its spatially resolved low-mass companion HD 155555 C). This is an intriguing system which shows properties of both an active pre-main sequence star and a synchronised (main sequence) binary. We obtain the emission measure distribution, temperature structures, plasma densities, and abundances of this system and compare them with the coronal properties of other young/active stars. HD 155555 AB and HD 155555 C produce copious X-ray emission with log Lx of 30.54 and 29.30, respectively, in the 0.3-6.0 keV energy band. The light curves of individual stars show variability on timescales of few minutes to hours. We analyse the dispersed spectra and reconstruct the emission measure distribution using spectral line analysis. The resulting elemental abundances exhibit inverse first ionisation potential effect in both cases. An analysis of He-like triplets yields a range of coronal electron densities ~10^10-10^13 cm-3. Since HD 155555 AB is classified both as an RS CVn and a PMS star, we compare our results with those of other slightly older active main-sequence stars and T Tauri stars, which indicates that the coronal properties of HD 155555 AB closely resemble that of an older RS CVn binary rather than a younger PMS star. Our results also suggests that the properties of HD 155555 C is very similar to those of other active M dwarfs.Comment: 17 pages, 23 figues, Accepted in Ap

Why Don't Prices Rise During Periods of Peak Demand? Evidence from Scanner Data

We examine the retail prices and wholesale prices of a large supermarket chain in Chicago over seven and one-half years. We show that prices tend to fall during the seasonal demand peak for a product and that changes in retail margins account for most of those price changes; thus we add to the growing body of evidence that markups are counter-cyclical. The pattern of margin changes that we observe is consistent with loss leader' models such as the Lal and Matutes (1994) model of retailer pricing and advertising competition. Other models of imperfect competition are less consistent with retailer behavior. Manufacturer behavior plays a more limited role in the counter-cyclicality of prices.

Deposing the Cool Corona of KPD 0005+5106

The ROSAT PSPC pulse height spectrum of the peculiar He-rich hot white dwarf KPD 0005+5106 provided a great surprise when first analysed by Fleming, Werner & Barstow (1993). It defied the best non-LTE modelling attempts in terms of photospheric emission from He-dominated atmospheres including C, N and O and was instead interpreted as the first evidence for a coronal plasma around a white dwarf. We show here that a recent high resolution Chandra LETGS spectrum has more structure than expected from a thermal bremsstrahlung continuum and lacks the narrow lines of H-like and He-like C expected from a coronal plasma. Moreover, a coronal model requires a total luminosity more than two orders of magnitude larger than that of the star itself. Instead, the observed 20-80 AA flux is consistent with photospheric models containing trace amounts of heavier elements such as Fe. The soft X-ray flux is highly sensitive to the adopted metal abundance and provides a metal abundance diagnostic. The weak X-ray emission at 1 keV announced by O'Dwyer et al (2003) instead cannot arise from the photosphere and requires alternative explanations. We echo earlier speculation that such emission arises in a shocked wind. Despite the presence of UV-optical O VIII lines from transitions between levels n=7-10, no X-ray O VIII Ly alpha flux is detected. We show that O VIII Lyman photons can be trapped by resonant scattering within the emitting plasma and destroyed by photoelectric absorption.Comment: 15 Pages, 4 figures. Accepted for the Astrophysical Journa

What have we learned about primary liver transplantation under tacrolimus immunosuppression? - Long-term follow-up of the first 1000 patients

Objective: To summarize the long-term efficacy and safety of tacrolimus in orthotopic liver transplant (OLT) recipients, as well as to examine the factors that influence long-term morbidity and mortality rates. Background: Tacrolimus (FK506, Prograf) was introduced as primary immunosuppression for primary liver transplantation in 1989; many subsquent trials have verified the association of tacrolimus with decreased rates of acute rejection and steroid-resistant rejection after OLT. Cumulative experience with tacrolimus has also defined its short- and intermediate-term toxicity. Methods: One thousand consecutive patients undergoing primary OLT at a single center from August 1989 to December 1992, under tacrolimus immunosuppression, were followed until January 1999. Patients were categorized by age. Mean follow-up was 93.4 ± 11 months after OLT. Patient survival, graft survival (with corresponding causes of death and retransplantation), and rejection rates (and corresponding doses of immunosuppression) were examined as efficacy parameters. Hypertension, renal function, incidence of malignancies, incidence of diabetes, and other toxicities were examined as safety parameters. Results: Actual 6-year overall patient survival rate was 68.1% and graft survival rate was 62.5%, with significant differences in the patterns of survival among the different age groups. After the first post-OLT year, infection, recurrence of disease, de novo malignancies, and cardiovascular events were the main causes of graft loss and death during the long-term follow-up. Graft loss related to either acute or chronic rejection was rare. The rate of acute rejection beyond 2 years was approximately 3% per year, and most were steroid-responsive. Approximately 70% of the patients were receiving tacrolimus monotherapy beyond year 1; at the latest follow-up, 74.2% were maintained on tacrolimus alone. In 6.1% of the survivors, end- stage renal disease developed during the follow-up period, requiring either dialysis or kidney transplantation. Hyperkalemia and hypertension was observed in approximately one third of the patients. Insulin-dependent diabetes mellitus (including patients who had diabetes before the transplant) was observed in 14% in year 1, dropping to 11% in year 7. In 82 patients, de novo malignancies developed; in 41 patients, lymphoproliferative disorders developed during the entire follow-up period. Conclusions: Long-term patient and graft survival rates are excellent under tacrolimus immunosuppression. Pediatric patients have a better long-term outcome than adults, in part because of the limited recurrence of the original disease, which was the most common cause of late graft loss (other than patient death, most commonly the result of late de novo malignancies and cardiovascular events). Graft loss from late rejection was rare

Best Prices

We explore the role of strategic price-discrimination by retailers for price determination and inflation dynamics. We model two types of customers, "loyals" who buy only one brand and do not strategically time purchases, and "shoppers" who seek out low-priced products both across brands and across time. Shoppers always pay the lowest price available, the "best price". Retailers in this setting optimally choose long periods of constant regular prices punctuated by frequent temporary sales. Supermarket scanner data confirm the model's predictions: the average price paid is closely approximated by a weighted average of the fixed weight average list price and the "best price". In contrast to standard menu cost models, our model implies that sales are an essential part of the price plan and the number and frequency of sales may be an important mechanism for adjustment to shocks. We conclude that our "best price" construct provides a tractable input for constructing price series.

Development and Validation of a Stability-Indicating RP-HPLC Method for Duloxetine Hydrochloride in its Bulk and Tablet Dosage Form

The objective of the present work was to develop a stability-indicating RP-HPLC method for duloxetine hydrochloride (DUL) in the presence of its degradation products generated from forced decomposition studies. The drug substance was found to be susceptible to stress conditions of acid hydrolysis. The drug was found to be stable to dry heat, photodegradation, oxidation and basic condition attempted. Successful separation of the drug from the degradation products formed under acidic stress conditions was achieved on a Hypersil C-18 column (250 mm × 4.6 mm id, 5μm particle size) using acetonitrile: 0.01 M potassium dihydrogen phosphate buffer (pH 5.4 adjusted with orthophosphoric acid) (50:50, v/v) as the mobile phase at a flow rate of 1.0 ml/min. Quantification was achieved with photodiode array detection at 229 nm over the concentration range 1–25 μg/ml with range of recovery 99.8–101.3 % for DUL by the RP-HPLC method. Statistical analysis proved the method to be repeatable, specific, and accurate for estimation of DUL. It can be used as a stability-indicating method due to its effective separation of the drug from its degradation products

Damping Analysis of Composites Used in Drilling Machine Bed

Vibrations are generally occurs during the machining process as drilling, milling etc. which is the main cause of defects in the machine tools. So vibrational damping study is very necessary for minimizing the vibrational effect on the machines bed. At present work glass fiber epoxy and glass fiber polyester are the composites used as the drilling machine bed as a base of the work piece. The purpose of the paper is to analyze the damping of sandwich composites used in this work is calculating by the energy balance approach method

Effect of an atom on a quantum guided field in a weakly driven fiber-Bragg-grating cavity

We study the interaction of an atom with a quantum guided field in a weakly driven fiber-Bragg-grating (FBG) cavity. We present an effective Hamiltonian and derive the density-matrix equations for the combined atom-cavity system. We calculate the mean photon number, the second-order photon correlation function, and the atomic excited-state population. We show that, due to the confinement of the guided cavity field in the fiber cross-section plane and in the space between the FBG mirrors, the presence of the atom in the FBG cavity can significantly affect the mean photon number and the photon statistics even though the cavity finesse is moderate, the cavity is long, and the probe field is weak.Comment: Accepted for Phys. Rev.