Development of an intense positron source using a crystal--amorphous hybrid target for linear colliders

In a conventional positron source driven by a few GeV electron beam, a high amount of heat is loaded into a positron converter target to generate intense positrons required by linear colliders, and which would eventually damage the converter target. A hybrid target, composed of a single crystal target as a radiator of intense gamma--rays, and an amorphous converter target placed downstream of the crystal, was proposed as a scheme which could overcome the problem.This paper describes the development of an intense positron source with the hybrid target. A series of experiments on positron generation with the hybrid target has been carried out with a 8--GeV electron beam at the KEKB linac. We observed that positron yield from the hybrid target increased when the incident electron beam was aligned to the crystal axis and exceeded the one from the conventional target with the converter target of the same thickness, when its thickness is less than about 2 radiation length. The measurements in the temperature rise of the amorphous converter target was successfully carried out by use of thermocouples. These results lead to establishment to the evaluation of the hybrid target as an intense positron source.Comment: 17pages, 10figure

A Case Study of Retro Commissioning in a Standard Commercial Office Building in Japan

This paper describes retro commissioning of a standard commercial office building in Japan. The owner's expectations for retro commissioning are realization of energy and cost savings, and controlling the increase in electric power demand, while continuing use of most existing equipment, and maintenance of high efficiency operation. First, the performance of the existing equipment was checked using the BEMS during retro commissioning program phase. Next, optimal selection of a system and heat source equipment was performed using the simulation in the design phase. Furthermore, the verification of the performance of the refrigeration machine installed was carried out as a Functional Performance Test. And the economic effect by a repair work was verified during the operation phase. The simple payback of the project was about six years

Circadian Gene Circuitry Predicts Hyperactive Behavior in a Mood Disorder Mouse Model

SummaryBipolar disorder, also known as manic-depressive illness, causes swings in mood and activity levels at irregular intervals. Such changes are difficult to predict, and their molecular basis remains unknown. Here, we use infradian (longer than a day) cyclic activity levels in αCaMKII (Camk2a) mutant mice as a proxy for such mood-associated changes. We report that gene-expression patterns in the hippocampal dentate gyrus could retrospectively predict whether the mice were in a state of high or low locomotor activity (LA). Expression of a subset of circadian genes, as well as levels of cAMP and pCREB, possible upstream regulators of circadian genes, were correlated with LA states, suggesting that the intrinsic molecular circuitry changes concomitant with infradian oscillatory LA. Taken together, these findings shed light onto the molecular basis of how irregular biological rhythms and behavior are controlled by the brain

Implementing sustainability co-creation between universities and society: A typology-based understanding

Universities are under mounting pressure to partner with societal stakeholders and organizations to collaboratively create and implement sustainability-advancing knowledge, tools, and societal transformations. Simultaneously, an increasing number of societal organizations are reaching out to partner with universities to achieve organizational objectives and increase the effectiveness of strategies to further societal sustainability. Using a conceptual framework of "sustainability co-creation", this study empirically examines the historical and ongoing experiences of five organizations in Japan that actively partner with universities to enhance sustainability activities and strategies to transform society. We examine motivations for partnering with universities, innovative models of practice, factors hampering the co-creative potential of the university, and desired changes to overcome these. Our empirical study leads to the proposal of a typology that might assist in categorizing and understanding key attributes of differing types of sustainability co-creation. We build our typology from two perspectives: First, in terms of the primary objective of the co-creation (ranging from knowledge production to the transformation of society), and second, in terms of the approach taken (ranging from either socially or technologically-centered). We then reflect on the organizations' experiences to offer several strategies that could increase the effectiveness of the university when partnering with stakeholders in sustainability co-creation. We also highlight several factors effecting the university's capacity to move beyond knowledge production towards implementation measures to transform society with external stakeholders

Enhancement of the Positron Intensity by a Tungsten Single Crystal Target at the KEKB Injector Linac

International audienceA new tungsten single-crystalline positron target has been successfully employed for generation of the intense positron beam at the KEKB injector linac in September 2006. The target is composed of a tungsten single-crystal with a thickness of 10.5 mm. The positron production target is bombarded at an incident electron energy of 4 GeV, and the produced positrons are collected and accelerated up to the final injection energy of 3.5 GeV in the succeeding sections. A conventional tungsten plate with a thickness of 14 mm has been used previously, and the conversion efficiency (Ne^+/Ne^-), the ratio between the number of positrons (Ne^+) captured in the positron capture section and the number of the incident electrons (Ne^-), was 0.20 on average. By replacing the tungsten plate with the tungsten crystal, it increased to 0.25 on average. The increase of the conversion efficiency has boosted the positron intensity to its maximum since the beginning of KEKB operation in 1999. Now this new positron source is stably operating and is contributing to increasing the integrated luminosity of the KEKB B-factory

Induced sensorimotor brain plasticity controls pain in phantom limb patients

The cause of pain in a phantom limb after partial or complete deafferentation is an important problem. A popular but increasingly controversial theory is that it results from maladaptive reorganization of the sensorimotor cortex, suggesting that experimental induction of further reorganization should affect the pain, especially if it results in functional restoration. Here we use a brain-machine interface (BMI) based on real-time magnetoencephalography signals to reconstruct affected hand movements with a robotic hand. BMI training induces significant plasticity in the sensorimotor cortex, manifested as improved discriminability of movement information and enhanced prosthetic control. Contrary to our expectation that functional restoration would reduce pain, the BMI training with the phantom hand intensifies the pain. In contrast, BMI training designed to dissociate the prosthetic and phantom hands actually reduces pain. These results reveal a functional relevance between sensorimotor cortical plasticity and pain, and may provide a novel treatment with BMI neurofeedback.This research was conducted under the ‘Development of BMI Technologies for Clinical Application’ of SRPBS by MEXT and AMED. This research was also supported in part by JST PRESTO; JSPS KAKENHI JP24700419, JP26560467, JP22700435, JP26242088, JP26282165, JP15H05710 and JP15H05920; Brain/MINDS and SICP from AMED; ImPACT; Ministry of Health, Labor, and Welfare (18261201); and the Japan Foundation of Aging and Health