Bij kanker zit ook partner in emotionele achtbaan

Hoe gaat het nou met jou? Partners van kankerpatiënten krijgen die vraag maar zelden te horen. En druk als ze zijn met de zorg voor de zieke, stellen ze hem zelf ook niet gauw. Psychische en fysieke klachten kunnen zich zo gemakkelijk opstapelen. Met de online zelfhulpcursus ‘Houvast, voor elkaar’ wil UT-promovenda Nadine Köhle hen helpen in balans te blijven

Elements at risk as a framework for assessing the vulnerability of communities to landslides

International audienceThe assessment of the vulnerability of communities prone to landslide related disasters is a topic that is growing in importance. Few studies discuss this issue and limited research has been carried out on the relationship between types of landslide and their potential impact on buildings and infrastructure. We outline a framework to undertake an assessment of the vulnerability of buildings to landslide utilising a similar framework used for assessing the vulnerability of buildings to tsunami damage. The framework is based on the development of an "elements at risk database" that takes into consideration the characteristics and use of the buildings, their importance for the local economy and the characteristics of the inhabitants (population density, age and so forth). The attributes that affect vulnerability are imported and examined within a GIS database which is used to visualise the physical, human and economic vulnerability. The results may have important implications for disaster management and emergency planning, and the database can be used by various end-users and stakeholders such as insurance companies, local authorities and the emergency services. The approach presented here can be integrated in to a wider more detailed "Framework for Landslide Risk and Vulnerability Assessment for Communities". We illustrate the potential of this framework and present preliminary results from Lichtenstein, Baden Württemberg, Germany

Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference