Astrophysical Insights into Radial Velocity Jitter from an Analysis of 600 Planet-search Stars

Radial velocity (RV) detection of planets is hampered by astrophysical processes on the surfaces of stars that induce a stochastic signal, or "jitter," which can drown out or even mimic planetary signals. Here, we empirically and carefully measure the RV jitter of more than 600 stars from the California Planet Search sample on a star by star basis. As part of this process, we explore the activity–RV correlation of stellar cycles and include appendices listing every ostensibly companion-induced signal we removed and every activity cycle we noted. We then use precise stellar properties from Brewer et al. to separate the sample into bins of stellar mass and examine trends with activity and with evolutionary state. We find that RV jitter tracks stellar evolution and that in general, stars evolve through different stages of RV jitter: the jitter in younger stars is driven by magnetic activity, while the jitter in older stars is convectively driven and dominated by granulation and oscillations. We identify the "jitter minimum"—where activity-driven and convectively driven jitter have similar amplitudes—for stars between 0.7 and 1.7 M⊙ and find that more-massive stars reach this jitter minimum later in their lifetime, in the subgiant or even giant phases. Finally, we comment on how these results can inform future RV efforts, from prioritization of follow-up targets from transit surveys like TESS to target selection of future RV surveys

Arousal regulates frequency tuning in primary auditory cortex.

Changes in arousal influence cortical sensory representations, but the synaptic mechanisms underlying arousal-dependent modulation of cortical processing are unclear. Here, we use 2-photon Ca2+ imaging in the auditory cortex of awake mice to show that heightened arousal, as indexed by pupil diameter, broadens frequency-tuned activity of layer 2/3 (L2/3) pyramidal cells. Sensory representations are less sparse, and the tuning of nearby cells more similar when arousal increases. Despite the reduction in selectivity, frequency discrimination by cell ensembles improves due to a decrease in shared trial-to-trial variability. In vivo whole-cell recordings reveal that mechanisms contributing to the effects of arousal on sensory representations include state-dependent modulation of membrane potential dynamics, spontaneous firing, and tone-evoked synaptic potentials. Surprisingly, changes in short-latency tone-evoked excitatory input cannot explain the effects of arousal on the broadness of frequency-tuned output. However, we show that arousal strongly modulates a slow tone-evoked suppression of recurrent excitation underlying lateral inhibition [H. K. Kato, S. K. Asinof, J. S. Isaacson, Neuron, 95, 412-423, (2017)]. This arousal-dependent "network suppression" gates the duration of tone-evoked responses and regulates the broadness of frequency tuning. Thus, arousal can shape tuning via modulation of indirect changes in recurrent network activity

HIV-associated multi-centric Castleman’s disease with multiple organ failure: cuccessful treatment with rituximab

Introduction: Multicentric Castleman's Disease (MCD), a lymphoproliferative disorder associated with Human Herpes Virus-8 (HHV-8) infection, is increasing in incidence amongst HIV patients. This condition is associated with lymphadenopathy, polyclonal gammopathy, hepato-splenomegaly and systemic symptoms. A number of small studies have demonstrated the efficacy of the anti-CD20 monoclonal antibody, rituximab, in treating this condition. Case presentation: We report the case of a 46 year old Zambian woman who presented with pyrexia, diarrhoea and vomiting, confusion, lymphadenopathy, and renal failure. She rapidly developed multiple organ failure following the initiation of treatment of MCD with rituximab. Following admission to intensive care (ICU), she received prompt multi-organ support. After 21 days on the ICU she returned to the haematology medical ward, and was discharged in remission from her disease after 149 days in hospital. Conclusion: Rituximab, the efficacy of which has thus far been examined predominantly in patients outside the ICU, in conjunction with extensive organ support was effective treatment for MCD with associated multiple organ failure. There is, to our knowledge, only one other published report of its successful use in an ICU setting, where it was combined with cyclophosphamide, adriamycin and prednisolone. Reports such as ours support the notion that critically unwell patients with HIV and haematological disease can benefit from intensive care

Network-Level Control of Frequency Tuning in Auditory Cortex

Lateral inhibition is a fundamental circuit operation that sharpens the tuning properties of cortical neurons. This operation is classically attributed to an increase in GABAergic synaptic input triggered by non-preferred stimuli. Here we use in vivo whole-cell recording and two-photon Ca imaging in awake mice to show that lateral inhibition shapes frequency tuning in primary auditory cortex via an unconventional mechanism: non-preferred tones suppress both excitatory and inhibitory synaptic inputs onto layer 2/3 cells ("network suppression"). Moreover, optogenetic inactivation of inhibitory interneurons elicits a paradoxical increase in inhibitory synaptic input. These results indicate that GABAergic interneurons regulate cortical activity indirectly via the suppression of recurrent excitation. Furthermore, the network suppression underlying lateral inhibition was blocked by inactivation of somatostatin-expressing interneurons (SOM cells), but not parvalbumin-expressing interneurons (PV cells). Together, these findings reveal that SOM cells govern lateral inhibition and control cortical frequency tuning through the regulation of reverberating recurrent circuits

Information-disturbance tradeoff in estimating a maximally entangled state

We derive the amount of information retrieved by a quantum measurement in estimating an unknown maximally entangled state, along with the pertaining disturbance on the state itself. The optimal tradeoff between information and disturbance is obtained, and a corresponding optimal measurement is provided.Comment: 4 pages. Accepted for publication on Physical Review Letter

Improving empathy of physicians through guided reflective writing

Objectives: This study was designed to explore how guided reflective writing could evoke empathy and reflection in a group of practicing physicians. Methods: Total participants recruited included 40 staff physicians at Cleveland Clinic, a tertiary care academic medical center. Twenty physicians (intervention group) were assigned to participate in a 6-session faculty development program introducing narrative medicine and engaging in guided reflective writing. Ten physicians (comparison group 1) received the assigned course reading materials but did not participate in the course sessions. Ten physicians (comparison group 2) neither received the reading materials nor participated in the sessions. Qualitative analysis of the physicians\u27 reflective writings was performed to identify major themes. The Jefferson Scale of Empathy was administered three times during the course. Results: Qualitative analysis of physicians\u27 writings showed themes of both compassionate solidarity and detached concern. Exploration of negative emotions occurred more frequently than positive ones. The most common writing style was case presentation. A total of 36 staff physicians completed the Jefferson Scale of Empathy. Results of statistical analysis suggested an improvement in empathy in the intervention group at the end of the course (p \u3c 0 .05). Conclusions: These results suggest a faculty development program using guided narrative writing can promote reflection and may enhance empathy among practicing physicians. These findings should encourage medical educators to design additional strategies for enhancing reflection and empathic behavior in trainees and specifically practicing physicians who can role model these behaviors to achieve the ultimate goal of improving the quality of patient care

Best Practices by Occupational and Physical Therapists Performing Seating and Mobility Evaluations

Occupational and Adult Educatio

Astrophysical Insights into Radial Velocity Jitter from an Analysis of 600 Planet-search Stars

Radial velocity (RV) detection of planets is hampered by astrophysical processes on the surfaces of stars that induce a stochastic signal, or "jitter," which can drown out or even mimic planetary signals. Here, we empirically and carefully measure the RV jitter of more than 600 stars from the California Planet Search sample on a star by star basis. As part of this process, we explore the activity–RV correlation of stellar cycles and include appendices listing every ostensibly companion-induced signal we removed and every activity cycle we noted. We then use precise stellar properties from Brewer et al. to separate the sample into bins of stellar mass and examine trends with activity and with evolutionary state. We find that RV jitter tracks stellar evolution and that in general, stars evolve through different stages of RV jitter: the jitter in younger stars is driven by magnetic activity, while the jitter in older stars is convectively driven and dominated by granulation and oscillations. We identify the "jitter minimum"—where activity-driven and convectively driven jitter have similar amplitudes—for stars between 0.7 and 1.7 M⊙ and find that more-massive stars reach this jitter minimum later in their lifetime, in the subgiant or even giant phases. Finally, we comment on how these results can inform future RV efforts, from prioritization of follow-up targets from transit surveys like TESS to target selection of future RV surveys