The Effect of a Frailty Management Program on the Rehabilitation of Elderly Patients after Surgical Treatment

The article performs the results of rehabilitation programs realized among senile patients after videolaparoscopic cholecystectomy, based on specific for geriatrics senile patients’ status assessment methods with determination of frailty and geriatric syndromes exten

Social and medical aspects longevity

The article deals with the demographical problem's population aging, life expectancy, premature aging, are shown results on quality of life in countries in relation to different indexes, that form itye

Frailty Syndrome and Main Geriatric Syndromes in Surgical Clinical Picture

The paper represents an original research dedicated to one of the topical issues of the modern geriatrics - frailty syndrome. The rate of the syndrome incidence among the patient of the elderly and old age of the surgical profile has been specified; the increase in prevalence and degree of the frailty syndrome severity in the patients after surgical treatment has been confirme

Frailty and age dynamics of separate clinical indicators in patients of therapeutic profile

Age-related dynamics of body homeostasis individual indicators in patients with risk of developing frailty and without frailty was studied in the research. Clinical indicators mostly associated with age were determined: muscle strength, glomerular filtration rate, total protein, potassium, hemoglobin, alanine aminotransferase activity, and blood plasma glucose. The contribution of reduced overall renal function, as well as anabolic activity of the liver in the development of age-related changes and frailty was studie

Neuroimmune and endocrine mechanisms of unfavorable geriatric status in patients with acute coronary syndrome

Background: Acute coronary syndrome (ACS) is the cause of above 70% of deaths in patients of older age. Frailty that develops in elderly patients provokes pro-inflammatory and neuroimmune inflammatory responses in the body that promote deterioration of the ACS course.Aim: To study neuroimmunoendocrine alterations in elderly patients with ACS depending on the presence or absence of the frailty syndrome.Materials and methods: The study was performed by retrospective, cross-sectional and prospective evaluation of the ACS patient registries within an international project GIRAFFE (Gerontological Research International Against Frailty: Fit Experience) in 2011–2015. We analyzed the results of measurement of serum tumor necrosis factor alfa (TNF-α) and the interleukin family (IL-1β, IL-4, IL-6, IL-10) in 633 patients with non-ST ACS (n = 270) and with ST-ACS (n = 363) at days 5, 12, and 26 from the beginning of the pain syndrome. From those, 265 patients were non-frail, 97 were pre-frail, and 271 patients had the frailty syndrome. The control group included 116 patients without significant somatic disease.Results: In all study groups of patients with non-ST ACS, there was an increase in IL-4, IL-6 and IL-10 levels, compared to their reference ranges, at day 5 from the beginning of the pain syndrome. Subsequently, these parameters were changing with therapy, similarly in all groups: IL-4 level gradually decreased by the end of the follow-up, IL-10 level increased by day 12 from the beginning of the pain syndrome and decreased by day 26. The lowest IL-10 levels compared to the reference range (1.5 ± 0.2 pg/mL) were seen in the elderly frail patients: 2.9 ± 0.6 pg/mL at day 5 from the beginning of the pain syndrome, 7.2 ± 1.2 pg/mL at day 12, and 1.9 ± 0.3 pg/mL at day 26, compared to 8 ± 1.2, 15.5 ± 1.6 and 6.2 ± 1.1 pg/mL in the isolated ACS group, respectively (all p < 0.05). In the group with non-ST ACS, higher TNF-α and IL-1β levels, compared to the control, were registered only in the elderly frail patients. Under treatment, these parameters did not reached the reference ranges, being 187.7 ± 6.5 and 310.2 ± 29.5 pg/mL at day 5 from the beginning of the pain syndrome, 165 ± 6 and 299.5 ± 29.4 pg/mL at day 12 and 154 ± 5.9 and 265.9 ± 27.9 at day 26, respectively, compared to 68.7 ± 3 pg/mL (p < 0.05 for all comparisons to the control group). In the ST-ACS patients, TNF-α, IL-1β, IL-4, IL-6, and IL-10 levels exceeded the reference ranges in all groups studied for the whole study duration. In the patients with the elderly frailty syndrome the serum concentrations of TNF-α, IL-1β, IL-6 and IL-10 were higher than in the non-frail and pre-frail patients with ST-ACS. The IL-4 levels were not informative for the assessment of the contribution of the elderly frailty to the ST-ACS course.Conclusion: The frailty syndrome of the elderly provokes the activation of the pro-inflammatory system that is confirmed by the consistent increase of serum pro-inflammatory mediators associated to the degree of the frailty syndrome in ACS patients

The Effect of a Frailty Management Program on the Rehabilitation of Elderly Patients after Surgical Treatment

The article performs the results of rehabilitation programs realized among senile patients after videolaparoscopic cholecystectomy, based on specific for geriatrics senile patients’ status assessment methods with determination of frailty and geriatric syndromes exten

Progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias

Aim. To develop a progressive multifaceted approach to the management of geriatric patients with cardiac arrhythmias.Material and methods. The study was carried out in 2 stages. The study sample consisted of 262 elderly and senile people (mean age, 69,5±1,1 years). There 145 elderly (mean age, 68,4±1,2 years) and 117 senile patients (mean age 74,4±1,3 years). We analyzed medications used for six months in geriatric patients with arrhytmias and senile asthenia (SA) and without it. The combined strategy of management of geriatric patients with arrhytmias and SA was tested.Results. SA is most common in geriatric patients who are taking drugs such as class I a, b, c antiarrhythmics, class V antiarrhythmics (cardiac glycosides), diuretics (torasemide, furosemide), and statins. This indicates the need to avoid polypharmacy and to adjust the treatment of geriatric patients with cardiac arrhythmias in accordance with Beers criteria. Presented study revealed that in patients with SA, the total antioxidant activity is reduced, which indicates the need to restore antioxidant defence to such patients. A combined strategy has been developed for the management of geriatric patients with cardiac arrhytmias and SA.Conclusion. The combined strategy of managing older patients with arrhytmias and SA helped to improve the geriatric status, prevent SA, and increase antioxidant defence. A significant improvement in the quality of life was noted, in particular, in relation to the mental and psychological well-being

The genesis of polymorbidity in elder female & the role of neuronspecific enolase

The problem of correlation between polymorbidity and neuronspecific enolase is presented in this article

Physiotherapy in the system of medical aid for elders

In modern medicine the physiotherapy is one of the main methods oа treatment and rehabilitation. This problem in elders is presented in this article

Social and medical aspects longevity

yesThe article deals with the demographical problem's population aging, life expectancy, premature aging, are shown results on quality of life in countries in relation to different indexes, that form i