Paper Session I-A - Modeling Current and Future Launch Vehicle Processing Using Object-Oriented Simulation Techniques

STARSIM, an acronym for Space Transportation Activities and Resources Simulation, is an objectoriented, menu-driven, user-friendly, decision support system for simulating National Space Transportation System (NSTS) processing, as well as Personnel Launch System (PLS)-National Launch System (NLS), PLS-Proton, PLS-Titan IV, Hermes-Ariane 5 and Cargo Transfer Return Vehicle (CTRV) processing. For each launch system modeled, output is displayed numerically (for global statistical information), in pie chart form (to visualize percentages of subcategories associated with a main category) and in Gantt chart form (for visualizing when and where each launch vehicle experiences waiting, processing, blocking and maintenance periods, and the reasons for blocking). Users may input a comprehensive set of system parameters (e.g., number of launch vehicles, processing times at each facility, number of bays at a particular facility) using a window-based environment, or by supplying an existing input data file. Data for existing launch systems and representative data for proposed systems are used to illustrate output for the models mentioned above. The object-oriented methodology employed in the initial model (i.e., NSTS processing) permitted additional models to be implemented in a minimum amount of time and effort

Kryptoracemates

Racemic crystals normally crystallise in centrosymmetric spacegroups containing equal numbers of enantiomers. More rarely, racemates may crystallise in non-centrosymmetric space-groups having glide symmetry or, even more rarely, in space-groups devoid of a centre of inversion, having no rotary-inversion axes nor glide plane. The latter class of crystals form the subject of the present bibliographic review – a survey of kryptoracemic behaviour. The term kryptoracemic alludes to the presence of a hidden or non-crystallographic centre of inversion between two molecules that might otherwise be expected to crystallise in an achiral space-group, often about a centre of inversion. Herein, examples of molecules with stereogenic centres crystallising in one of the 65 Sohncke space-groups are described. Genuine kryptoracemates, i.e. crystals comprising only enantiomorphous pairs are described followed by an overview of non-genuine kryptoracemates whereby the crystal also contains other species such as solvent and/or counterions. A full range, i.e. one to six, stereogenic centres are noted in genuine kryptoracemates. Examples will also be described whereby there are more that one enantiomeric pair of molecules in the crystallographic asymmetric unit. A more diverse range of examples are available for non-genuine kryptoracemates. There are unbalanced species where in addition to the enantiomeric pair of molecules, there is another enantiomeric molecule present. There are examples of genuine co-crystals, solvated species and of salts. Finally, special examples will be highlighted where the counterions are chiral and where they are disparate, both circumstances promoting kryptoracemic behaviour

Minimal Disturbance Back-Propagation Algorithm

Summary form only given, as follows. A novel learning algorithm for multilayered neural networks is presented. This algorithm, called minimal disturbance backpropagation, approximates a least mean squared error minimization of the error function while minimally disturbing the connection weights in the network. This means that the information previously trained into the network is disturbed to the smallest amount possible while achieving the desired error correction. Simulation results indicate that this algorithm is more robust and yields much faster convergence rates than the standard backpropagation algorithm

Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy

Human pancreatic islets are seldom assessed for dynamic responses to external stimuli. Thus, the elucidation of human islet functionality would provide insights into the progression of diabetes mellitus, evaluation of preparations for clinical transplantation, as well as for the development of novel therapeutics. The objective of this study was to develop a microfluidic platform for in vitro islet culture, allowing the multi-parametric investigation of islet response to chemical and biochemical stimuli. This was accomplished through the fabrication and implementation of a microfluidic platform that allowed the perifusion of islet culture while integrating real-time monitoring using impedance spectroscopy, through microfabricated, interdigitated electrodes located along the microchamber arrays. Real-time impedance measurements provide important dielectric parameters, such as cell membrane capacitance and cytoplasmic conductivity, representing proliferation, differentiation, viability, and functionality. The perifusion of varying glucose concentrations and monitoring of the resulting impedance of pancreatic islets were performed as proof-of-concept validation of the lab-on-chip platform. This novel technique to elucidate the underlying mechanisms that dictate islet functionality is presented, providing new information regarding islet function that could improve the evaluation of islet preparations for transplantation. In addition, it will lead to a better understanding of fundamental diabetes-related islet dysfunction and the development of therapeutics through evaluation of potential drug effects

Microfluidic platform for assessing pancreatic islet functionality through dielectric spectroscopy

Human pancreatic islets are seldom assessed for dynamic responses to external stimuli. Thus, the elucidation of human islet functionality would provide insights into the progression of diabetes mellitus, evaluation of preparations for clinical transplantation, as well as for the development of novel therapeutics. The objective of this study was to develop a microfluidic platform for in vitro islet culture, allowing the multi-parametric investigation of islet response to chemical and biochemical stimuli. This was accomplished through the fabrication and implementation of a microfluidic platform that allowed the perifusion of islet culture while integrating real-time monitoring using impedance spectroscopy, through microfabricated, interdigitated electrodes located along the microchamber arrays. [...