22 research outputs found
Familial mutations in fibrinogen Aα (FGA) chain identified in renal amyloidosis increase in vitro amyloidogenicity of FGA fragment
No full textLearning from Synthetic Models of Extracellular Matrix; Differential Binding of Wild Type and Amyloidogenic Human Apolipoprotein A-I to Hydrogels Formed from Molecules Having Charges Similar to Those Found in Natural GAGs
No full textClinical Proteome Informatics Workbench Detects Pathogenic Mutations in Hereditary Amyloidoses
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Graphene-based label-free electrochemical aptasensor for rapid and sensitive detection of foodborne pathogen
No full textElectrochemical Biosensors for miRNA Detection
No full textMicroRNAs (miRNAs) are intensely studied as candidates for diagnostic and prognostic biomarkers. They are naturally occurring small RNAs (approximately 22 nucleotides in length) that act as regulators of protein translation. Because many diseases are caused by the misregulated activity of proteins, miRNAs have been implicated in a number of diseases including a broad range of cancers, heart disease, and immunological and neurological diseases. A great deal of effort, therefore, has been devoted to developing analytical methods for miRNA analysis. The consideration when selecting existing or designing new methods for miRNA analysis includes sensitivity and multiplexing capability without PCR. In this chapter, novel electrochemical strategies for miRNA detection and quantification will be reviewed
