Journal of sol gel science and technology

Early hypertext systems were monolithic and closed, but newer systems tend to be open, distributed, and support collaboration. While this development has resulted in increased openness and flexibility, integrating or adapting various different tools, such as content editors, viewers or even other link servers has remained a tedious task. Many developers were implementing essentially similar components, simply for the benefit of having their own platform on which to experiment with hypertexts. The open hypermedia community is addressing this issue of interoperability between open hypermedia systems. The goal of the community is to provide an open hypermedia framework that can be used by application developers outside the community to construct more powerful hypermedia-aware applications. The design and evolution of this framework is presented along with the requirements that drove its development. The framework has matured to the point where it has supported the creation of a number of research prototypes. These prototypes are described and evaluated with respect to their use of the framework

Query Evaluation in an Object-Oriented Multimedia Mediator

A multimedia mediator aims at providing a well-structured gateway to some application dependent part of a federated multimedia system. Our specific design employs proxy objects for external multimedia items and introduces a new concept of semi-structured and self-describing types for multimedia items. Query evaluation and optimization hide all details of communication with external sources and explore the external parallel computation capacities, the selectivity of local preprocessing, and the impact of materialization

Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancer: a HuGE-GSEC review

The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html ). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer