Buddy Bench: A Strategy to Increase Social Inclusion for Students with Special Needs

Buddy Bench: A Strategy to Increase Social Inclusion for Students with Special Need

Optimising the location of tsunami detection buoys and sea-level monitors in the Indian Ocean

In the wake of the 2004 Boxing Day tsunami disaster, a global response to implement a tsunami warning system in the Indian Ocean became imperative. Steps in this direction were initiated in 2005 with plans for the deployment of up to 24 tsunami detection buoys. The purpose of this paper is to investigate the optimal placement of tsunami detection buoys and sea-level monitors, in order to provide warning to the greatest population potentially affected. We adopt a mathematical programming approach to examine this problem. It is determined that 10 sites are essential in ensuring that the maximum population can be warned. This has implications for construction and maintenance of the tsunami warning system in the Indian Ocean. Copyright © 2010 Inderscience Enterprises Ltd

Global intensity correction in dynamic scenes

Changing image intensities causes problems for many computer vision applications operating in unconstrained environments. We propose generally applicable algorithms to correct for global differences in intensity between images recorded with a static or slowly moving camera, regardless of the cause of intensity variation. The proposed intensity correction is based on intensity quotient estimation. Various intensity estimation methods are compared. Usability is evaluated with background classification as example application. For this application we introduced the PIPE error measure evaluating performance and robustness to parameter setting. Our approach retains local intensity information, is always operational and can cope with fast changes in intensity. We show that for intensity estimation, robustness to outliers is essential for dynamic scenes. For image sequences with changing intensity, the best performing algorithm (MofQ) improves foreground-background classification results up to a factor two to four on real data

Genetic background of cholesterol gallstone disease

AbstractCholesterol gallstone formation is a multifactorial process involving a multitude of metabolic pathways. The primary pathogenic factor is hypersecretion of free cholesterol into bile. For people living in the Western Hemisphere, this is almost a normal condition, certainly in the elderly, which explains the very high incidence of gallstone disease. It is probably because the multifactorial background genes responsible for the high incidence have not yet been identified, despite the fact that genetic factors clearly play a role. Analysis of the many pathways involved in biliary cholesterol secretion reveals many potential candidates and considering the progress in unraveling the regulatory mechanisms of the responsible genes, identification of the primary gallstone genes will be successful in the near future

Gut microbiota, metabolism and psychopathology:A critical review and novel perspectives

Psychiatric disorders are often associated with metabolic comorbidities. However, the mechanisms through which metabolic and psychiatric disorders are connected remain unclear. Pre-clinical studies in rodents indicate that the bidirectional signaling between the intestine and the brain, the so-called microbiome-gut-brain axis, plays an important role in the regulation of both metabolism and behavior. The gut microbiome produces a vast number of metabolites that may be transported into the host and play a part in homeostatic control of metabolism as well as brain function. In addition to short chain fatty acids, many of these metabolites have been identified in recent years. To what extent both microbiota and their products control human metabolism and behavior is a subject of intense investigation. In this review, we will discuss the most recent findings concerning alterations in the gut microbiota as a possible pathophysiological factor for the co-occurrence of metabolic comorbidities in psychiatric disorders

The short-chain fatty acid uptake fluxes by mice on a guar gum supplemented diet associate with amelioration of major biomarkers of the metabolic syndrome

Studies with dietary supplementation of various types of fibers have shown beneficial effects on symptoms of the metabolic syndrome. Short-chain fatty acids (SCFAs), the main products of intestinal bacterial fermentation of dietary fiber, have been suggested to play a key role. Whether the concentration of SCFAs or their metabolism drives these beneficial effects is not yet clear. In this study we investigated the SCFA concentrations and in vivo host uptake fluxes in the absence or presence of the dietary fiber guar gum. C57Bl/6J mice were fed a high-fat diet supplemented with 0%, 5%, 7.5% or 10% of the fiber guar gum. To determine the effect on SCFA metabolism, C-13-labeled acetate, propionate or butyrate were infused into the cecum of mice for 6 h and the isotopic enrichment of cecal SCFAs was measured. The in vivo production, uptake and bacterial interconversion of acetate, propionate and butyrate were calculated by combining the data from the three infusion experiments in a single steady-state isotope model. Guar gum treatment decreased markers of the metabolic syndrome (body weight, adipose weight, triglycerides, glucose and insulin levels and HOMA-IR) in a dose-dependent manner. In addition, hepatic mRNA expression of genes involved in gluconeogenesis and fatty acid synthesis decreased dose-dependently by guar gum treatment. Cecal SCFA concentrations were increased compared to the control group, but no differences were observed between the different guar gum doses. Thus, no significant correlation was found between cecal SCFA concentrations and metabolic markers. In contrast, in vivo SCFA uptake fluxes by the host correlated linearly with metabolic markers. We argue that in vivo SCFA fluxes, and not concentrations, govern the protection from the metabolic syndrome by dietary fibers

Genetic variances, trends and mode of inheritance for hip and elbow dysplasia in Finnish dog populations

The aims of this study were to assess genetic variances, trends and mode of inheritance for hip and elbow dysplasia in Finnish dog populations. The influence of time-dependent fixed effects in the model when estimating the genetic trends was also studied. Official hip and elbow dysplasia screening records of 42 421 dogs from seven breeds were analysed with REML. To investigate the mode of inheritance of hip and elbow dysplasia, trait distributions, genetic variances and regressions of offspring phenotypes on parental predicted breeding values were studied separately in males and in females. Genetic trends for hip dysplasia between the years 1983 and 1998 were favourable only in the Rottweiler. In elbow dysplasia, the trends were favourable after the year 1992 in all the four breeds studied but the overall changes were small. The reason for this seemed to be negligible selection pressure against these traits. Time-dependent fixed effects in the model had an influence on the estimated genetic trends, resulting either in a more negative or more positive genetic trend compared with the model from which the time-dependent effects were removed. Mitochondrial or sex-linked inheritance did not seem likely in the expression of hip and elbow dysplasia in the populations studied. Regression coefficients of offspring phenotypes on estimated parental breeding values were approximately equal to their expected value in a situation with equal parental contribution. Furthermore, the phenotypic frequency distributions of hip and elbow dysplasia grades were similar among males and females in each breed studied. No indication of major genes was found in the offspring frequency distributions within individual sires. According to these Finnish data, mode of inheritance for both hip and elbow dysplasia is polygenic (quantitative) with equal expression of the genes from both parents, although the estimates of heritability for hip dysplasia in the Rough Collie and for elbow dysplasia in the German Shepherd and the Golden Retriever were somewhat different in males compared with females