Clinical efficacy of Kapha Ketu Rasa on Tamaka Swasa

Context: Compound drugs are scientifically formulated aiming to get the desired therapeutic effects through synergy. Kapha Ketu Rasa is one such compound drug which is a classical herbo mineral marine Khalvi Rasayana judicially containing Shankha Bhasma, Vatsanabha, Tankana and Pippali. Treating GERD along with the treatment of bronchial asthma will enhance the clinical success rate. At this juncture, it is worth to notice the pharmacology of Kapha Ketu Rasa in the same perspective. Aims: To study the clinical effect of Kapha Ketu Rasa on Tamaka Swasa (Bronchial asthma). Materials and Methods: 30 Patients of Tamaka Swasa irrespective of age, sex, religion etc., were randomly selected and treated with 125 mg of Kapha Ketu Rasa capsules twice a day with Ardraka Swarasa before meals for 21 days, then followed for 21 more days. Results: The clinical study showed statistically highly significant improvement in both subjective and objective parameters viz. Kasa (91%), Ghurghurata (83%) and Swasakruchrata (82%) including decrease in AEC, ESR, Differential eosinophil count and PEF was also statistically significantly improved. Conclusions: Kapha Ketu Rasa is an effective Vyadhi Pratyanika herbo mineral Shamana Rasayana in the management of Tamaka Swasa

Biodegradation of Synthetic Polyesters (BTA and PCL) with Natural Flora in Soil Burial and Pure Cultures under Ambient Temperature

Abstract: The aim of this study was to study the biodegradation of two synthetic polyesters, one aliphaticaromatic (1, 4-butanediol, terephthalic-adipic acid, BTA) and the other aliphatic (poly (,-caprolactone), PCL, under different soil types (canal shore soil, garden soil, compost and Peat moss, respectively), as well as using locally isolated cultures at ambient temperature. The results showed that the BTA films buried in canal shore and garden soil were degraded faster than that in the other soils. After six weeks about 90, 88 and 80% were degraded in garden, canal shore soil and compost respectively, while only 52% were degraded in Peat moss. On the other hand, 95 and 93% weight loss was obtained for PCL films buried for three weeks in canal shore and garden soil respectively. The Scanning Electron Microscope photos confirm the results of weight loss and revealed the presence of cracks and fungal growth on films buried in different soils. The results with pure cultures, especially with Fusarium solani, also confirmed the biodegradability of two polyesters under ambient temperature. Finally, it could be concluded that both synthetic polyester are degradable under ambient conditions

Sensor Based Wearable System to Assist Paralytic Patient with Continuous Health Monitoring

In Today�s world many people are suffering from paralysis and most of the paralytic patients are dependent on care takers. Paralysis is a condition in which there is impairment of one or more muscles in the body. In order to assist these patients, fingers of the hand play a major role in this proposed system. The patient is made to wear the sensor glove and recognition of finger bending is the mathematical interpretation of finger movement by the computing device. The system ensures the patient to express his requirements by converting the finger bending into auditory speech. If the same action is repeated thrice, indicating that the requirement is not yet fulfilled, the system will send a text message to the concerned care taker with the help of GSM module. Home appliances are also controlled by the patient�s finger wearing the sensor glove. In addition to this, the system continuously monitors the patient�s heart beat and body temperature. If the body temperature and heart beat exceeds the normal value, the buzzer will be activated to show the abnormalities with respect to patient so that the care taker can attend the patient

Modeling of Degradation in Gas Turbine Engine by Modified Off Design Simulation

Legacy turbojet engines suffer degradation in performance with usage. Degradations in engine components show different observable symptoms based on the control mode of the engine. Hence, to accurately model the engine and its degradations, a novel off-design modeling method that considers the control settings of the engine is presented. The improvement in degradation modeling due to the modified scheme is presented in detail. The mathematical model used in the degradation simulation is validated by comparing the model outputs to the engine mounted sensor measurements at various ratings in the engine test bed. The estimation component parameters used in the model through nonlinear gas path analysis and optimisation-based routines is also presented

Endophytes: A Treasure House of Bioactive Compounds of Medicinal Importance

Endophytes are an endosymbiotic group of microorganisms that colonize in plants and microbes that can be readily isolated from any microbial or plant growth medium. They act as reservoirs of novel bioactive secondary metabolites, such as alkaloids, phenolic acids, quinones, steroids, saponins, tannins, and terpenoids that serve as a potential candidate for antimicrobial, anti-insect, anticancer and many more properties. While plant sources are being extensively explored for new chemical entities for therapeutic purposes, endophytic microbes also constitute an important source for drug discovery. This review aims to comprehend the contribution and uses of endophytes as an impending source of drugs against various forms of diseases and other possible medicinal use

Shapes and Positions of Black Hole Shadows in Accretion Disks and Spin Parameters of Black Holes

Can we determine a spin parameter of a black hole by observation of a black hole shadow in an accretion disk? In order to answer this question, we make a qualitative analysis and a quantitative analysis of a shape and a position of a black hole shadow casted by a rotating black hole on an optically thick accretion disk and its dependence on an angular momentum of a black hole. We have found black hole shadows with a quite similar size and a shape for largely different black hole spin parameters and a same black hole mass. Thus, it is practically difficult to determine a spin parameter of a black hole from a size and a shape of a black hole shadow in an accretion disk. We newly introduce a bisector axis of a black hole shadow named a shadow axis. For a rotating black hole a shape and a position of a black hole shadow are not symmetric with respect to a rotation axis of a black hole shadow. So, in this case the minimum interval between a mass center of a black hole and a shadow axis is finite. An extent of this minimum interval is roughly proportional to a spin parameter of a black hole for a fixed inclination angle between a rotation axis of a black hole and a direction of an observer. In order to measure a spin parameter of a black hole, if a shadow axis is determined observationally, it is crucially important to determine a position of a mass center of a black hole in a region of a black hole shadow.Comment: 13 pages, 6 figures, accepted for publication in Ap

Periodontal Management of Non Healing Endodontic Lesion– A Case Report

The fact that the periodontium is anatomically interrelated with the dental pulp by virtue of apical foramina and lateral canals creates pathways for exchange of noxious agents between the two tissue compartments when either or both of the tissues are diseased. Proper diagnosis of the various disorders affecting the periodontium and the pulp is important to exclude unnecessary and even detrimental treatment. This is a clinical case report of an enododontic–periodontic lesion in relation to lower left central incisor. Root canal treatment has been done with the respected tooth six months ago, but the lesion showed no sign of healing resulting in draining sinus and increasing pocket depth. Radiographic examination revealed over-obturation of gutta-percha with peri-radicular pathology. Periodontal flap surgery was performed and the defect was filled with bone graft mixed with Platelet rich plasma (PRP) and covered by platelet rich fibrin (PRF). Patient reviewed for six months which showed uneventful healing and no recurrence of the lesion

Effects of residual stresses on interlaminar radial strength of Glass-Epoxy L-bend composite laminates

The built-in heterogeneity of the composite laminates has been exploited to tailor the stiffness and strength requirements of modern structures to meet the specific functional demands. However, the non-homogeneity in these composites is the root cause for most of their failures. One of the undesirable consequences of the inherited heterogeneity is the development of cure-induced stresses during composite manufacturing. This work aims to investigate the influence of process-induced stresses on interlaminar radial strength in curved composite laminates. Glass-Epoxy (GE) laminates of two different thicknesses were prepared by hand lamination technique using V-shaped tooling and cured under room temperature. The state of residual stresses in GE laminates is varied by post-curing these laminates at different temperatures. Curved bending strength (CBS) and corresponding interlaminar radial stress for delamination of L-bend laminates were evaluated experimentally using four points bending test. The residual stress profile in each GE laminate is experimentally characterized by employing the Slitting method. The results indicate that the residual stresses have a negligible effect on the critical stress for initial delamination in GE laminates. But, the critical stress for delamination was found to be independent of the laminate thickness and increased with higher curing temperatures. The delaminated surfaces of L-bend laminates were studied using a scanning electronic microscope (SEM). The enhancement in the critical stress due to post-curing can be attributed to the improved fiber-matrix interfacial bonding with higher curing temperature