Towards an Unsupervised Method for Network Anomaly Detection in Large Datasets

In this paper, we present an effective tree based subspace clustering technique (TreeCLUSS) for finding clusters in network intrusion data and for detecting known as well as unknown attacks without using any labelled traffic or signatures or training. To establish its effectiveness in finding the appropriate number of clusters, we perform a cluster stability analysis. We also introduce an effective cluster labelling technique (CLUSSLab) to label each cluster based on the stable cluster set obtained from TreeCLUSS. CLUSSLab is a multi-objective technique that employs an ensemble approach for labelling each stable cluster generated by TreeCLUSS to achieve high detection rate. We also introduce an effective unsupervised feature clustering technique to identify the dominating feature set from each cluster. We evaluate the performance of both TreeCLUSS and CLUSSLab using several real world intrusion datasets to identify known as well as unknown attacks and find that results are excellent

Impact of energy-momentum conservation violation on the configuration of compact stars and their GW echoes

This work investigates the impacts of energy-momentum conservation violation on the configuration of strange stars constraint with gravitational wave (GW) event GW190814 as well as eight recent observations of compact objects. The gravitational wave echoes from these interesting classes of compact objects are also calculated. To describe the matter of strange stars, we have used two different equations of state (EoSs): first an ad-hoc exotic EoS, the stiffer MIT Bag model and next realistic CFL phase of quark matter EoS. We choose Rastall gravity as a simple model with energy-momentum conservation violation with a set of model parameter values. Our results show that this gravity theory permits stable solutions of strange stars and the resulting structures can foster GW echoes. We illustrate the implication of the gravity theory and found that the negative values of the Rastall parameter result in more compact stellar configurations and lower GW echo frequency. With an increase in the Rastall parameter, both the compactness of the stellar configurations and echo time decrease. It is worth mentioning here that with the chosen set of some probable strange star candidates from observational data and also in light of GW 190814, we have evaluated the radii of stellar models. Also, the GW echo frequencies associated with strange stars are found to be in the range of $\approx 41-58$ kHz for both cases.Comment: 8 figures and 4 table

Genetic Parameters of Common Wheat in Nepal

Knowledge on variation within traits and their genetics are prerequisites in crop improvement program. Thus, in present paper we aimed to estimate genetic and environmental indices of common wheat genotypes. For the purpose, eight quantitative traits were measured from 30 wheat genotypes, which were in randomized complete block design with 3 replicates. Components of variance and covariance were estimated along with heritability, genetic gain, realized heritability, coheritability and correlated response. Differences between phenotypic and genotypic variances in heading days, maturity days and plant height were not large. Grain yield and plant height showed the highest phenotypic (18.189%) and genotypic (12.06%) coefficient of variances, respectively. Phenotypic covariance was higher than genotypic and environmental covariance in most of the traits. The highest heritability and realized heritability were of heading days followed by maturity days. Genetic gain for plant height was the highest. Co-heritability of 1000-grain weight with tillers number was the highest. The highest correlated response was expressed by grain yield with tillers number. This study indicates the possibility of improving wheat genotypes through selection utilizing existing variation in these traits.Journal of Nepal Agricultural Research Council Vol.1 2015 pp.9-1

An incremental clustering of gene expression data

Abstract-This paper presents an incremental clustering algorithm based on DGC, a density-based algorithm we developed earlier [1]. We experimented with real-life datasets and both methods perform satisfactorily. The methods have been compared with some well-known clustering algorithms and they perform well in terms of z-score cluster validity measure

A Requirement for Global Transcription Factor Lrp in Licensing Replication of Vibrio cholerae Chromosome 2

The human pathogen, Vibrio cholerae, belongs to the 10% of bacteria in which the genome is divided. Each of its two chromosomes, like bacterial chromosomes in general, replicates from a unique origin at fixed times in the cell cycle. Chr1 initiates first, and upon duplication of a site in Chr1, crtS, Chr2 replication initiates. Recent in vivo experiments demonstrate that crtS binds the Chr2-specific initiator RctB and promotes its initiator activity by remodeling it. Compared to the well-defined RctB binding sites in the Chr2 origin, crtS is an order of magnitude longer, suggesting that other factors can bind to it. We developed an in vivo screen to identify additional crtS-binding proteins and identified the global transcription factor, Lrp, as one such protein. Studies in vivo and in vitro indicate that Lrp binds to crtS and facilitates RctB binding to crtS. Chr2 replication is severely defective in the absence of Lrp, indicative of a critical role of the transcription factor in licensing Chr2 replication. Since Lrp responds to stresses such as nutrient limitation, its interaction with RctB presumably sensitizes Chr2 replication to the physiological state of the cell

Ribosome-DnaK interactions in relation to protein folding

Bacterial ribosomes or their 50S subunit can refold many unfolded proteins. The folding activity resides in domain V of 23S RNA of the 50S subunit. Here we show that ribosomes can also refold a denatured chaperone, DnaK, in vitro, and the activity may apply in the folding of nascent DnaK polypeptides in vivo. The chaperone was unusual as the native protein associated with the 50S subunit stably with a 1:1 stoichiometry in vitro. The binding site of the native protein appears to be different from the domain V of 23S RNA, the region with which denatured proteins interact. The DnaK binding influenced the protein folding activity of domain V modestly. Conversely, denatured protein binding to domain V led to dissociation of the native chaperone from the 50S subunit. DnaK thus appears to depend on ribosomes for its own folding, and upon folding, can rebind to ribosome to modulate its general protein folding activity