The Concept of Raktamokshana in the management of Badhirya

The ear is a complex and sensitive organ in our body. Unfortunately, damage to the organ, whether through any disease, physical insult, long term exposure excessive noise, some drugs or simply the effects of aging, can cause the ear to malfunction. The result of malfunction is usually to produce some degree of deafness. Hearing impairment is affecting more than 360 million persons of the world (5. % of the world’s population). Among them, 328 million (91%) are adult (183 million male and 145 million females) and 32 million (9%) of these are children. In Ayurveda, it can be correlated with Badhirya. Ayurvedic science may help to cure the disease. In Ayurvedic literature, many treatment modalities are mentioned for Badhirya like Snehavirechana, Raktmokshana, Basti Karma, Murdhabasti, Nasya, Dhupana. Raktamokshana is one of the treatment mentioned by Acharyas. According to Acharya Sushruta, vitiated Vatadosha along with Kaphadosha resides in Shabdanu Vaha Sira and leads to Badhirya. Acharya Sushruta has mentioned Rakstmokshana when Vata resides in the Sira and Shirah. So Raktmokshana can play an important role in the management of Badhirya

Efficient synthesis, molecular docking and biological evaluation of novel isatine linked spiroheterocycle through multi-component reaction

400-406In this work, twelve compounds have been newly synthesized by one pot N-Mannich base multicomponent reaction. The synthesized compounds have been characterized by using FT-IR, 1H and 13C NMR and mass spectrometry. The final compounds have been evaluated for their in vitro antibacterial and antifungal activity using agar-well diffusion method. The tested compounds show poor to good activity with inhibition zone value between 8 to 25 mm, when compared to reference Ciprofloxacin and Flocanazole. Among them compounds 6b, 6c, 6d and 6g show most promoting activity against E.coli, B. cereus, B. substilis, A. niger and R. nigricans