1,094 research outputs found

    Pretreatment health measures and complications after surgical management of elderly women with breast cancer

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    Elderly patients with breast cancer are less likely to be offered surgery, partly owing to co-morbidities and reduced functional ability. However, there is little consensus on how best to assess surgical risk in this patient group.The ability of pretreatment health measures to predict complications was investigated in a prospective cohort study of a consecutive series of women aged at least 70 years undergoing surgery for operable (stage I-IIIa) breast cancer at 22 English breast units between 2010 and 2013. Data on treatment, surgical complications, health measures and tumour characteristics were collected by case-note review and/or patient interview. Outcome measures were all complications and serious complications within 30 days of surgery.The study included 664 women. One or more complications were experienced by 41·0 per cent of the patients, predominantly seroma or primary/minor infections. Complications were serious in 6·5 per cent. More extensive surgery predicted a higher number of complications, but not serious complications. Older age did not predict complications. Several health measures were associated with complications in univariable analysis, and were included in multivariable analyses, adjusting for type/extent of surgery and tumour characteristics. In the final models, pain predicted a higher count of complications (incidence rate ratio 1·01, 95 per cent c.i. 1·00 to 1·01; P = 0·004). Fatigue (odds ratio (OR) 1·02, 95 per cent c.i. 1·01 to 1·03; P = 0·004), low platelet count (OR 4·19, 1·03 to 17·12: P = 0·046) and pulse rate (OR 0·96, 0·93 to 0·99; P = 0·010) predicted serious complications.The risk of serious complications from breast surgery is low for older patients. Surgical decisions should be based on patient fitness rather than age. Health measures that predict surgical risk were identified in multivariable models, but the effects were weak, with 95 per cent c.i. close to unity.This paper presents independent research funded by theBreast Cancer Campaign (2008NOVPR35), a NationalInstitute for Health Research (NIHR) Programme Grantfor Applied Research (RP-PG-0608-10168) and researcharising from a Post Doctoral Fellowship supported by theNIHR (PDF/01/2008/027). The views expressed in thispublication are those of the authors and not necessarilythose of the NHS, the NIHR or the Department of Health

    Using the NPSS Environment to Model an Altitude Test Facility

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    An altitude test facility was modeled using Numerical Propulsion System Simulation (NPSS). This altitude test facility model represents the most detailed facility model developed in the NPSS architecture. The current paper demonstrates the use of the NPSS system to define the required operating range of a component for the facility. A significant number of additional component models were easily developed to complete the model. Discussed in this paper are the additional components developed and what was done in the development of these components

    Meson Structure Functions in Valon Model

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    Parton distributions in a {\it{valon}} in the next-to-leading order is used to determine the patron distributions in pion and kaon. The validity of the valon model is tested and shown that the partonic content of the valon is universal and independent of the valon type. We have evaluated the valon distribution in pion and kaon, and in particular it is shown that the results are in good agreement with the experimental data on pion structure in a wide range of x=[104,1]x=[10^{-4},1]Comment: 13 pages with 7 figures included, The manuscript is revised, figures are added and some errors are corrected. Accepted for publication in Physical Review

    Charges in Gauge Theories

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    In this article we investigate charged particles in gauge theories. After reviewing the physical and theoretical problems, a method to construct charged particles is presented. Explicit solutions are found in the Abelian theory and a physical interpretation is given. These solutions and our interpretation of these variables as the true degrees of freedom for charged particles, are then tested in the perturbative domain and are demonstrated to yield infra-red finite, on-shell Green's functions at all orders of perturbation theory. The extension to collinear divergences is studied and it is shown that this method applies to the case of massless charged particles. The application of these constructions to the charged sectors of the standard model is reviewed and we conclude with a discussion of the successes achieved so far in this programme and a list of open questions.Comment: 47 pages, LaTeX, 14 figures, uses feynmp, necessary Metapost files included. Review to appear in Pramana, Journal of Physics. Minor LaTeX change to make page numbers visible on "Letter" paper forma

    Squeezed gluon vacuum and the global colour model of QCD

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    We discuss how the vacuum model of Celenza and Shakin with a squeezed gluon condensate can explain the existence of an infrared singular gluon propagator frequently used in calculations within the global colour model. In particular, it reproduces a recently proposed QCD-motivated model where low energy chiral parameters were computed as a function of a dynamically generated gluon mass. We show how the strength of the confining interaction of this gluon propagator and the value of the physical gluon condensate may be connected.Comment: 13 pages, LaTe

    PIN32 COST-EFFECTIVENESS OF 2009 PANDEMIC INFLUENZA A(H I N I) VACCINATION IN THE UNITED STATES

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    Symmetry breaking, conformal geometry and gauge invariance

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    When the electroweak action is rewritten in terms of SU(2) gauge invariant variables, the Higgs can be interpreted as a conformal metric factor. We show that asymptotic flatness of the metric is required to avoid a Gribov problem: without it, the new variables fail to be nonperturbatively gauge invariant. We also clarify the relations between this approach and unitary gauge fixing, and the existence of similar transformations in other gauge theories.Comment: 11 pages. Version 2: typos corrected, discussion of Elitzur's theorem added. Version to appear in J.Phys.
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