Jefferson Graduate Certificate Programs for Career Advancement

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Facial diplegia with hyperreflexia-a mild Guillain-Barre Syndrome variant, to treat or not to treat?

Guillain Barre Syndrome (GBS) is readily diagnosed when the presentation is that of ascending weakness and areflexia. Atypical presentations with preserved, and at times, brisk reflexes, can be a diagnostic dilemma. We describe a patient with GBS who presented with facial diplegia and hyperreflexia on examination and discuss management options

Type I cAMP-Dependent Protein Kinase Delays Apoptosis in Human Neutrophils at a Site Upstream of Caspase-3

Current data suggest that apoptosis controls neutrophil numbers in tissues. We analyzed roles for and the sites of action for the cAMP-dependent protein kinases (cAPKs) in apoptosis induced in human neutrophils by in vitro storage, cycloheximide (CHX) exposure, and anti-Fas exposure. Treatment with 8-chlorophenylthio-cAMP (8-CPT-cAMP) prolonged the time required for 50% of the cells to exhibit apoptotic morphology (t 50) from 16.3 to 41.8 h (in vitro culture), from 2.4 to 7.8 h (CHX), and from 4.8 to 6.5 h (anti-Fas). CHX ± 8-CPT-cAMP did not significantly alter resting intracellular calcium levels and H-89, a selective inhibitor of cAPK, had no effect on apoptosis in the absence of the analogue. In contrast, site-selective cAMP analogues that specifically activated the type I cAPK, but not type II cAPK, synergistically attenuated apoptosis. Exposure to 8-CPT-cAMP delayed, in parallel, the activity of caspase-3 (CPP-32β), whereas mitogen-activated protein kinase kinase (MAPKK) inhibitor, PD98059, had no effect on CHX-induced apoptosis ± 8-CPT-cAMP. Together these results indicate that type I cAPK activation is necessary and sufficient to mediate cAMP-induced delay in human neutrophil apoptosis induced by several mechanisms and suggest that one of the major sites of cAPK action is upstream of caspase-3 (CPP-32β) activation

Credit card fraud detection: An application of the gene expression messy genetic algorithm

This paper describes an application of the recently introduced gene expression messy genetic algorithm (GEMGA) (Kargupta, 1996) for detecting fraudulent transactions of credit cards. It also explains the fundamental concepts underlying the GEMGA in the light of the SEARCH (Search Envisioned As Relation and Class Hierarchizing) (Kargupta, 1995) framework

Constrained blackbox optimization: The SEARCH perspective

Search and optimization in the context of blackbox objective function evaluation subject to blackbox constraints satisfaction is the thesis of this work. The SEARCH (Search Envisioned As Relation and Class Hierarchizing) framework introduced by Kargupta (1995) offered an alternate perspective of blackbox optimization in terms of relations, classes, and partial ordering. The primary motivation comes from the observation that sampling in blackbox optimization is essentially an inductive process and in the absence of any relation among the members of the search space, induction is no better than enumeration. SEARCH also offers conditions for polynomial complexity search and bounds on sample complexity using its ordinal, probabilistic, and approximate framework. In this work the authors extend the SEARCH framework to tackle constrained blackbox optimization problems. The methodology aims at characterizing the search domain into feasible and infeasible relations among which the feasible relations can be explored further to optimize an objective function. Both -- objective function and constraints -- can be in the form of blackboxes. The authors derive results for bounds on sample complexity. They demonstrate their methodology on several benchmark problems

Probing RS scenarios of flavour at LHC via leptonic channels

We study a purely leptonic signature of the Randall-Sundrum scenario with Standard Model fields in the bulk at LHC: the contribution from the exchange of Kaluza-Klein (KK) excitations of gauge bosons to the clear Drell-Yan reaction. We show that this contribution is detectable (even with the low luminosities of the LHC initial regime) for KK masses around the TeV scale and for sufficiently large lepton couplings to KK gauge bosons. Such large couplings can be compatible with ElectroWeak precision data on the Zff coupling in the framework of the custodial O(3) symmetry recently proposed, for specific configurations of lepton localizations (along the extra dimension). These configurations can simultaneously reproduce the correct lepton masses, while generating acceptably small Flavour Changing Neutral Current (FCNC) effects. This LHC phenomenological analysis is realistic in the sense that it is based on fermion localizations which reproduce all the quark/lepton masses plus mixing angles and respect FCNC constraints in both the hadron and lepton sectors.Comment: 15 pages, 6 Figures, Latex fil

Evidence of kaon nuclear and Coulomb potential effects on soft K+ production from nuclei

The ratio of forward K+ production on copper, silver and gold targets to that on carbon has been measured at proton beam energies between 1.5 and 2.3 GeV as a function of the kaon momentum p_K using the ANKE spectrometer at COSY-Juelich. The strong suppression in the ratios observed for p_K<200-250 MeV/c can be ascribed to a combination of Coulomb and nuclear repulsion in the K+A system. This opens a new way to investigate the interaction of K+-mesons in the nuclear medium. Our data are consistent with a K+A nuclear potential of V_K~20 MeV at low kaon momenta and normal nuclear density. Given the sensitivity of the data to the kaon potential, the current experimental precision might allow one to determine V_K to better than 3 MeV.Comment: 9 pages, 3 figures; changed conten

Measurement of the isospin-filtering dd -> 4He K+ K- reaction at Q=39 MeV

The total cross section for the dd -> 4He K+ K- reaction has been measured at a beam momentum of 3.7 GeV/c, corresponding to an excess energy of 39 MeV, which is the maximum possible at the Cooler Synchrotron COSY-J\"{u}lich. A deuterium cluster-jet target and the ANKE forward magnetic spectrometer, placed inside the storage ring, have been employed in this investigation. We find a total cross section of sigma(tot) < 14 pb, which brings into question the viability of investigating the dd -> 4He a0(980) reaction as a means of studying isospin violation.Comment: Five pages with three eps figure