72 research outputs found
Determination of Strange Sea Quark Distributions from Fixed-target and Collider Data
We present an improved determination of the strange sea distribution in the
nucleon with constraints coming from the recent charm production data in
neutrino-nucleon deep-inelastic scattering by the NOMAD and CHORUS experiments
and from charged current inclusive deep-inelastic scattering at HERA. We
demonstrate that the results are consistent with the data from the ATLAS and
the CMS experiments on the associated production of -bosons with
-quarks. We also discuss issues related to the recent strange sea
determination by the ATLAS experiment using LHC collider data.Comment: 23 pages, 14 figure
Histaminylation of glutamine residues is a novel posttranslational modification implicated in G-protein signaling
Posttranslational modifications (PTM) have been shown to be essential for protein function and signaling. Here we report the identification of a novel modification, protein transfer of histamine, and provide evidence for its function in G protein signaling. Histamine, known as neurotransmitter and mediator of the inflammatory response, was found incorporated into mastocytoma proteins. Histaminylation was dependent on transglutaminase II. Mass spectrometry confirmed histamine modification of the small and heterotrimeric G proteins Cdc42, Galphao1 and Galphaq. The modification was specific for glutamine residues in the catalytic core, and triggered their constitutive activation. TGM2-mediated histaminylation is thus a novel PTM that functions in G protein signaling. Protein alphamonoaminylations, thus including histaminylation, serotonylation, dopaminylation and norepinephrinylation, hence emerge as a novel class of regulatory PTMs
Modified Wandzura-Wilczek Relation with the Nachtmann Variable
If one retains M^2/Q^2 terms in the kinematics, the Nachtmann variable \xi
seems to be more appropriate to describe deep inelastic lepton-nucleon
scattering. Up to the first power of M^2/Q^2, a modified Wandzura-Wilczek
relation with respect to \xi was derived. Kinematical correction factors are
given as functions of \xi and Q^2. A comparison of the modified g_2^WW(\xi) and
original g_2^WW(x) with the most recent g_2 data is shown.Comment: 10 pages, 3 figures, revised version with minor correction
Higher Twist, Scaling, and Effective for Lepton Scattering in the Few GeV Region
We use a new scaling variable , and add low modifications to
GRV98 leading order parton distribution functions such that they can be used to
model electron, muon and neutrino inelastic scattering cross sections (and also
photoproduction) at both very low and high energies.Comment: 6 pages, 3 figures. To be published in J. Phys. G (Conf. Proceedings)
based on two talks by Arie Bodek at the NuFact conference, Imperial
College, London, England, July 200
Constraints from Precision Electroweak Data on Leptoquarks and Bileptons
Explicit expressions are derived for the oblique parameters and in
certain extensions of the standard model. In particular, we consider
leptoquarks and bileptons, and find phenomenological constraints on their
allowed masses. Leptoquarks suggested by the neutral and charged current
anomalies at HERA can give improved agreement with both and . If
bileptons are the only new states, the singly-charged one must be heavier than
the directly-established lower limit. Finally, we study SU(15) grand
unification and show that there are regions of parameter space where the theory
is compatible with experimental data.Comment: 25 pages LaTeX including 7 figures. With improved comparison to
experimental data and other update
In utero exposure to cigarette chemicals induces sex-specific disruption of one-carbon metabolism and DNA methylation in the human fetal liver
Background: Maternal smoking is one of the most important modifiable risk factors for low birthweight, which is strongly associated with increased cardiometabolic disease risk in adulthood. Maternal smoking reduces the levels of the methyl donor vitamin B12 and is associated with altered DNA methylation at birth. Altered DNA methylation may be an important mechanism underlying increased disease susceptibility; however, the extent to which this can be induced in the developing fetus is unknown.
Methods: In this retrospective study, we measured concentrations of cobalt, vitamin B12, and mRNA transcripts encoding key enzymes in the 1-carbon cycle in 55 fetal human livers obtained from 11 to 21 weeks of gestation elective terminations and matched for gestation and maternal smoking. DNA methylation was measured at critical regions known to be susceptible to the in utero environment. Homocysteine concentrations were analyzed in plasma from 60 fetuses. Results: In addition to identifying baseline sex differences, we found that maternal smoking was associated with sex-specific alterations of fetal liver vitamin B12, plasma homocysteine and expression of enzymes in the 1-carbon cycle in fetal liver. In the majority of the measured parameters which showed a sex difference, maternal smoking reduced the magnitude of that difference. Maternal smoking also altered DNA methylation at the imprinted gene IGF2 and the glucocorticoid receptor (GR/NR3C1).
Conclusions: Our unique data strengthen studies linking in utero exposures to altered DNA methylation by showing, for the first time, that such changes are present in fetal life and in a key metabolic target tissue, human fetal liver. Furthermore, these data propose a novel mechanism by which such changes are induced, namely through alterations in methyl donor availability and changes in 1-carbon metabolism
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics
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