19,106 research outputs found
Radio Observations of the Supernova Remnant Candidate G312.5-3.0
The radio images from the Parkes-MIT-NRAO (PMN) Southern Sky Survey at 4850
MHz have revealed a number of previously unknown radio sources. One such
source, G312.5-3.0 (PMN J1421-6415), has been observed using the
multi-frequency capabilities of the Australia Telescope Compact Array (ATCA) at
frequencies of 1380 MHz and 2378 MHz. Further observations of the source were
made using the Molonglo Observatory Synthesis Telescope (MOST) at a frequency
of 843 MHz. The source has an angular size of 18 arcmin and has a distinct
shell structure. We present the reduced multi-frequency observations of this
source and provide a brief argument for its possible identification as a
supernova remnant.Comment: 5 pages, 5 figures, Accepted for publication in MNRA
Nonlocal feedback in ferromagnetic resonance
Ferromagnetic resonance in thin films is analyzed under the influence of
spatiotemporal feedback effects. The equation of motion for the magnetization
dynamics is nonlocal in both space and time and includes isotropic, anisotropic
and dipolar energy contributions as well as the conserved Gilbert- and the
non-conserved Bloch-damping. We derive an analytical expression for the
peak-to-peak linewidth. It consists of four separate parts originated by
Gilbert damping, Bloch-damping, a mixed Gilbert-Bloch component and a
contribution arising from retardation. In an intermediate frequency regime the
results are comparable with the commonly used Landau-Lifshitz-Gilbert theory
combined with two-magnon processes. Retardation effects together with Gilbert
damping lead to a linewidth the frequency dependence of which becomes strongly
nonlinear. The relevance and the applicability of our approach to ferromagnetic
resonance experiments is discussed.Comment: 22 pages, 9 figure
The Physics of Supernova Remnant Blast Waves. I. Kinematics of DEM L71 in the Large Magellanic Cloud
We present the results from Fabry-Perot imaging spectroscopy of the
Balmer-dominated supernova remnant DEM L71 (0505-67.9) in the LMC. Spectra
extracted from the entire circumference of the blast wave reveal the broad and
narrow component H-alpha line emission characteristic of non-radiative shocks
in partially neutral gas. The new spectra of DEM L71 include portions of the
rim that have not been previously observed. We find that the broad component
width varies azimuthally along the edge of DEM L71, ranging from 450+/-60 km/s
along the eastern edge to values as high as 985 (+210)(-165) km/s along the
faint western edge. In part of the faint northern rim the broad component is
not detected, possibly indicating a lower density in these regions and/or a
broad component width in excess of 1000 km/s. Between the limits of zero and
full electron-ion temperature equilibration at the shock front, the allowed
range of shock velocities is 430-560 km/s along the east rim and 700-1250 km/s
along other parts of the blast wave. The H-alpha broad-to-narrow flux ratios
vary considerably around the remnant, ranging from 0.4 to 0.8. These ratios lie
below the values predicted by our shock models. We find that narrow component
H-alpha emission from a cosmic ray precursor may be the cause of the
discrepancy. The least decelerated portions of the blast wave (i.e., regions
excluding the brightest filaments) are well characterized by Sedov models with
a kinetic energy E_51= (0.37+/-0.06)*D_50**(5/2), where D_50 is the LMC
distance in units of 50 kpc. The corresponding age for DEM L71 is
(4360+/-290)*D_50 yr. This is the first time that velocity information from the
entire blast wave has been utilized to study the global kinematics of a
non-radiative SNR at a known distance.Comment: 21 pages, including 8 postscript figures and 4 tables, LaTeX,
accepted to ApJ; see companion pape
Assessing the link between implementation fidelity and health outcomes for a trial of intensive case management by community health workers: a mixed methods study protocol
Background: Better systems of care are required to address chronic disease in Indigenous people to ensure they can access all their care needs. Health research has produced evidence about effective models of care and chronic disease strategies to address Indigenous health, however the transfer of research findings into routine clinical practice has proven challenging. Complex interventions, such as those related to chronic disease, have many components that are often poorly implemented and hence rarely achieve implementation fidelity. Implementation fidelity is "the degree to which programs are implemented as intended by the program developer". Knowing if an intervention was implemented as planned is fundamental to knowing what has contributed to the success of an intervention. Methods: The aim of this study is to adapt the implementation fidelity framework developed by Keith et al. and apply it to the intervention implemented in phase 1 of the Getting Better at Chronic Care in North Queensland study. The objectives are to quantify the level of implementation fidelity achieved during phase 1 of the study, measure the association between implementation fidelity and health outcomes and to explore the features of the primary health care system that contributed to improved health outcomes. A convergent parallel mixed methods study design will be used to develop a process for assessing implementation fidelity. Information collected via a questionnaire and routine data generated during phase 1 of the study will be used to explain the context for the intervention in each site and develop an implementation fidelity score for each component of the intervention. A weighting will be applied to each component of the intervention to calculate the overall implementation score for each participating community. Statistical analysis will assess the level of association between implementation fidelity scores and health outcomes. Discussion: Health services research seeks to find solutions to social and technical problems to improve health outcomes. The development of a tool and methodology for assessing implementation fidelity in the Indigenous primary health care context will help address some of the barriers to the translation of research into practice.Barbara Schmidt, Kerrianne Watt, Robyn McDermott and Jane Mill
Far-flung Filaments of Ejecta in the Young Supernova Remnant G292.0+1.8
New optical images of the young SNR G292.0+1.8, obtained from the 0.9-m
telescope at CTIO, show a more extensive network of filaments than had been
known previously. Filaments emitting in [O III] are distributed throughout much
of the 8 arcmin diameter shell seen in X-ray and radio images, including a few
at the very outermost shell limits. We have also detected four small complexes
of filaments that show [S II] emission along with [OIII]. In a single long-slit
spectrum we find variations of almost an order of magnitude in the relative
strengths of oxygen and sulfur lines, which must result from abundance
variations. None of the filaments, with or without [S II], shows any evidence
for hydrogen, so all appear to be fragments of pure SN ejecta. The [S II]
filaments provide the first evidence for undiluted products of oxygen burning
in the ejecta from the supernova that gave rise to G292.0+1.8. Some oxygen
burning must have occurred, but the paucity of [S II]-emitting filaments
suggests that either the oxygen burning was not extensive or that most of its
products have yet to be excited. Most of the outer filaments exhibit radial,
pencil-like morphologies that suggest an origin as Rayleigh-Taylor fingers of
ejecta, perhaps formed during the explosion. Simulations of core-collapse
supernovae predict such fingers, but these have never before been so clearly
observed in a young SNR. The total flux from the SNR in [OIII] 5007 is 5.4 *
10**-12 ergs/cm**2/s. Using a distance of 6 kpc and an extinction correction
corresponding to E(B-V) = 0.6 (lower than previous values but more consistent
both with our data and radio and X-ray estimates of NH), this leads to a
luminosity of 1.6 * 10**35 ergs/s in the 5007 Ang. line.Comment: 32 pages including 10 figures, and 3 tables, accepted for publication
in AJ. Vol 132, July 2006. Higher resolution versions of the figures and a
pdf of the manuscript can be found at
http://www-int.stsci.edu/~long/papers/g292_optical
Urine Proteomics Analysis of Patients with Neuronal Ceroid Lipofuscinoses
The Neuronal Ceroid Lipofuscinoses (NCL) are a group of 13 rare neurodegenerative disorders characterised by accumulation of cellular storage bodies. There are few therapeutic options and existing tests do not monitor disease progression and treatment response. However, urine biomarkers could address this need. Proteomic analysis of CLN2 patient urine revealed activation of immune response pathways and pathways associated with the unfolded protein response. Analysis of CLN5 and CLN6 sheep model urine showed subtle changes. To confirm and investigate the relevance of candidate biomarkers a targeted LC-MS/MS proteomic assay was created. We applied this assay to additional CLN2 samples as well as other NCL patients, (CLN1, CLN3, CLN5, CLN6 and CLN7) and demonstrated that Hexosaminidase-A, Aspartate Aminotransferase-1 and LAMP1, are increased in NCL samples and betaine-homocysteine S-methyltransferase-1 was specifically increased in CLN2 patients. These proteins could be used to monitor effectiveness of future therapies aimed at treating systemic NCL disease
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Notations and conventions in molecular spectroscopy: part 1. General spectroscopic notation
The field of Molecular Spectroscopy was surveyed in order to determine a set of
conventions and symbols which are in common use in the spectroscopic literature. This
document, which is Part I in a series, establishes the notations and conventions used for
general spectroscopic notations and deals with quantum mechanics, quantum numbers
(vibrational states, angular momentum and energy levels), spectroscopic transitions, and
miscellaneous notations (e.g. spectroscopic terms). Further parts will follow, dealing inter
alia with symmetry notation, permutation and permutation-inversion symmetry notation,
vibration-rotation spectroscopy and electronic spectroscopy
Altered expression of caspases-4 and -5 during inflammatory bowel disease and colorectal cancer : diagnostic and therapeutic potential
Caspases are a group of proteolytic enzymes involved in the co-ordination of cellular processes, including cellular homeostasis, inflammation and apoptosis. Altered activity of caspases, particularly caspase-1, has been implicated in the development of intestinal diseases, such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). However, the involvement of two related inflammatory caspase members, caspases-4 and -5, during intestinal homeostasis and disease has not yet been established. This study demonstrates that caspases-4 and -5 are involved in IBD-associated intestinal inflammation. Furthermore, we found a clear correlation between stromal caspase-4 and -5 expression levels, inflammation and disease activity in ulcerative colitis patients. Deregulated intestinal inflammation in IBD patients is associated with an increased risk of developing CRC. We found robust expression of caspases-4 and -5 within intestinal epithelial cells, exclusively within neoplastic tissue, of colorectal tumours. An examination of adjacent normal, inflamed and tumour tissue from patients with colitis-associated CRC confirmed that stromal expression of caspases-4 and -5 is increased in inflamed and dysplastic tissue, while epithelial expression is restricted to neoplastic tissue. In addition to identifying caspases-4 and -5 as potential targets for limiting intestinal inflammation, this study has identified epithelial-expressed caspases-4 and -5 as biomarkers with diagnostic and therapeutic potential in CRC
EUVE Observations of the Magnetic Cataclysmic Variable QQ Vulpeculae
We present simultaneous X-ray (lambda_peak ~ 44A) and EUV (lambda_peak = 89A)
light curves for the magnetic cataclysmic variable QQ Vulpeculae, obtained with
the EUVE satellite. We find that the unique shape of the X-ray light curve is
different from previously obtained X-ray light curves of QQ Vul and provides
evidence for two-pole accretion. Detailed examination of the photometric data
indicates that QQ Vul undergoes a stellar eclipse of the X-ray emitting region,
indicative of a high binary inclination. We discuss possible implications for
the nature of this system given the observed shape of its EUV and X-ray light
curves.Comment: 12 pages including 4 figures, accepted to PAS
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