Peripherality of breakup reactions

The sensitivity of elastic breakup to the interior of the projectile wave function is analyzed. Breakup calculations of loosely bound nuclei (8B and 11Be) are performed with two different descriptions of the projectile. The descriptions differ strongly in the interior of the wave function, but exhibit identical asymptotic properties, namely the same asymptotic normalization coefficient, and phase shifts. Breakup calculations are performed at intermediate energies (40-70 MeV/nucleon) on lead and carbon targets as well as at low energy (26 MeV) on a nickel target. No dependence on the projectile description is observed. This result confirms that breakup reactions are peripheral in the sense that they probe only the external part of the wave function. These measurements are thus not directly sensitive to the total normalization of the wave function, i.e. spectroscopic factor.Comment: Reviewed version accepted for publication in Phys. Rev. C; 1 new section (Sec. III E), 2 new figures (Figs. 3 and 5

Intermediate energy Coulomb excitation as a probe of nuclear structure at radioactive beam facilities

The effects of retardation in the Coulomb excitation of radioactive nuclei in intermediate energy collisions (Elab ~100 MeV/nucleon) are investigated. We show that the excitation cross sections of low-lying states in 11Be, {38,40,42}S and {44,46}Ar projectiles incident on gold and lead targets are modified by as much as 20% due to these effects. The angular distributions of decaying gamma-rays are also appreciably modified.Comment: 21 pages, 3 figures, Phys. Rev. C, in pres

Coulomb Excitation of Multi-Phonon Levels of the Giant Dipole Resonance

A closed expression is obtained for the cross-section for Coulomb excitation of levels of the giant dipole resonance of given angular momentum and phonon number. Applications are made to the Goldhaber-Teller and Steinwedel-Jensen descriptions of the resonance, at non-relativistic and relativistic bombarding energies.Comment: 16 pages, 5 figure

The Semiclassical Coulomb Interaction

The semiclassical Coulomb excitation interaction is at times expressed in the Lorentz gauge in terms of the electromagnetic fields and a contribution from the scalar electric potential. We point out that the potential term can make spurious contributions to excitation cross sections, especially when the the decay of excited states is taken into account. We show that, through an appropriate gauge transformation, the excitation interaction can be expressed in terms of the electromagnetic fields alone.Comment: 12 pages. Phys. Rev. C, Rapid Communication, in pres

Semiclassical treatment of fusion processes in collisions of weakly bound nuclei

We describe a semiclassical treatment of nuclear fusion reactions involving weakly bound nuclei. In this treatment, the complete fusion probabilities are approximated by products of two factors: a tunneling probability and the probability that the system is in its ground state at the strong absorption radius. We investigate the validity of the method in a schematic two-channel application, where the channels in the continuum are represented by a single resonant state. Comparisons with full coupled-channels calculations are performed. The agreement between semiclassical and quantal calculations isquite good, suggesting that the procedure may be extended to more sophisticated discretizations of the continuum.Comment: 11 pages, 5 figure

Long-Time Behavior of Velocity Autocorrelation Function for Interacting Particles in a Two-Dimensional Disordered System

The long-time behavior of the velocity autocorrelation function (VACF) is investigated by the molecular dynamics simulation of a two-dimensional system which has both a many-body interaction and a random potential. With strengthening the random potential by increasing the density of impurities, a crossover behavior of the VACF is observed from a positive tail, which is proportional to t^{-1}, to a negative tail, proportional to -t^{-2}. The latter tail exists even when the density of particles is the same order as the density of impurities. The behavior of the VACF in a nonequilibrium steady state is also studied. In the linear response regime the behavior is similar to that in the equilibrium state, whereas it changes drastically in the nonlinear response regime.Comment: 12 pages, 5 figure

Embryonic Precursor Cells from the Rhombic Lip Are Specified to a Cerebellar Granule Neuron Identity

AbstractThe specification of diverse classes of neurons is critical to the development of the cerebellar cortex. Here, we describe the purification of early embryonic precursors of cerebellar granule neurons from the rhombic lip, the dorsal aspect of the midbrain/hindbrain region. Isolation of rhombic lip cells reveals a homogenous population of precursor cells that express general neuronal markers and the granule cell marker RU49, but fail to extend neurites or express differentiation markers. Differentiation is induced by coculture with external germinal layer (EGL) cells, or their membranes, suggesting that a local inducing factor acts after formation of the EGL. Thus, proliferating precursors within the rhombic lip are specified to be granule cells very early, with the availability of an inducing factor increasing over the course of development

Selective Targeting to Glioma with Nucleic Acid Aptamers

Malignant glioma is characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue; hence, diagnosis and treatment is difficult and patient survival is poor. Aptamers contribute a promising and unique technology for the in vitro imaging of live cells and tissues, with a potentially bright future in clinical diagnostics and therapeutics for malignant glioma. The binding selectivity, uptake capacity and binding target of two DNA aptamers, SA43 and SA44, were investigated in glioma cells and patient tissues. The binding assay showed that SA43 and SA44 bound with strong affinity (Kd, 21.56 ± 4.60 nM and Kd, 21.11 ± 3.30 nM respectively) to the target U87MG cells. Quantitative analysis by flow cytometry showed that the aptamers were able to actively internalise in U87MG and 1321N1 glioma cells compared to the non-cancerous and non-glioma cell types. Confocal microscopy confirmed staining in the cytoplasm, and co-localisation studies with endoplasmic reticulum, Golgi apparatus and lysosomal markers suggested internalisation and compartmentalisation within the endomembrane system. Both aptamers selectively bound to Ku 70 and Ku 80 DNA repair proteins as determined by aptoprecipitation (AP) followed by mass spectrometry analysis and confirmation by Western blot. In addition, aptohistochemical (AHC) staining on paraffin embedded, formalin fixed patient tissues revealed that the binding selectivity was significantly higher for SA43 aptamer in glioma tissues (grade I, II, III and IV) compared to the non-cancerous tissues, whereas SA44 did not show selectivity towards glioma tissues. The results indicate that SA43 aptamer can differentiate between glioma and non-cancerous cells and tissues and therefore, shows promise for histological diagnosis of glioma

Coulomb corrected eikonal description of the breakup of halo nuclei

The eikonal description of breakup reactions diverges because of the Coulomb interaction between the projectile and the target. This divergence is due to the adiabatic, or sudden, approximation usually made, which is incompatible with the infinite range of the Coulomb interaction. A correction for this divergence is analysed by comparison with the Dynamical Eikonal Approximation, which is derived without the adiabatic approximation. The correction consists in replacing the first-order term of the eikonal Coulomb phase by the first-order of the perturbation theory. This allows taking into account both nuclear and Coulomb interactions on the same footing within the computationally efficient eikonal model. Excellent results are found for the dissociation of 11Be on lead at 69 MeV/nucleon. This Coulomb Corrected Eikonal approximation provides a competitive alternative to more elaborate reaction models for investigating breakup of three-body projectiles at intermediate and high energies.Comment: 19 pages, 9 figures, accepted for publication in Phys. Rev.

Structure Effects on Coulomb Dissociation of 8^8B

Coulomb Dissociation provides an alternative method for determining the radiative capture cross sections at astrophysically relevant low relative energies. For the breakup of $^8$B on $^{58}$Ni, we calculate the total Coulomb Dissociation cross section and the angular distribution for E1, E2 and M1. Our calculations are performed first within the standard first order semiclassical theory of Coulomb Excitation, including the correct three body kinematics, and later including the projectile-target nuclear interactions.Comment: 6 pages, proceedings from International Workshop on RNB, Puri, India, January 1998 - to be published in J. Phys.