CoPd alloy nanoparticles catalyzed tandem ammonia borane dehydrogenation and reduction of aromatic nitro, nitrile and carbonyl compounds

Can, Hasan/0000-0002-5723-2959; Metin, Onder/0000-0003-1622-4992WOS: 000346214100020Addressed herein is a general and facile route for the reduction of aromatic nitro, nitrile, and carbonyl compounds to the corresponding primary amines and alcohols, respectively, under ambient conditions. Our reduction approach comprises the tandem AB dehydrogenation and hydrogenation of unsaturated organic groups catalyzed by reduced graphene oxide supported Co30Pd70 alloy nanoparticles (rGO-Co30Pd70) in water/methanol mixture (v/v = 7/3) at room temperature. Monodisperse Co30Pd70 alloy NPs were synthesized by using an organic solution phase protocol involving the co-reduction of cobalt(II) acetylacetonate and palladium(II) acetylacetonate in oleylamine and borane-tert-butylamine mixture at 100 degrees C. The colloidal Co30Pd70 NPs were assembled on reduced graphene oxide (rGO-Co30Pd70) before their use as catalysts in the tandem reactions. A variety of aromatic nitro, nitriles, and carbonyl compounds were tested by the rGO-Co30Pd70 catalyzed tandem reaction and all the corresponding primary amines or alcohols were obtained by the yields reaching up to 99% within reaction times of 5-15 min. (C) 2014 Elsevier B.V. All rights reserved.Scientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z276]; Turkish Academy of Science Young Scientist program (TUBA-GEBIP)Turkish Academy of SciencesThe financial support by the Scientific and Technological Research Council of Turkey (TUBITAK, Project No: 113Z276) and partial support by Turkish Academy of Science Young Scientist program (TUBA-GEBIP) is highly acknowledged

A Novel Method for the Synthesis of Newfangled Asymmetric Schiff Bases from -amino Acids under Ultrasonic Conditions and in Aqueous Medium

WOS: 000385373600009Chiral Schiff bases were obtained at high yields via a novel technique. Aryl aldehydes and chiral -amino acids were treated (1) in the presence of H3PO4 in ethanol at 80 degrees C for 24 h, and (2) in the presence of K2CO3 under ultrasonic conditions in an aqueous ethanol medium within 5 min with yields reaching up to 96%. The results showed that the presented methodology under ultrasonic conditions was effective, practical, and eco-friendly compared to that using an acidic medium. The corresponding asymmetric Schiff bases were synthesized for the first time, and were characterized by H-1 and C-13 nuclear magnetic resonance and infrared spectroscopy and high-resolution mass spectrometry.TUBA (Turkish Academy of Sciences)Turkish Academy of SciencesThe authors are grateful to TUBA (Turkish Academy of Sciences) for their support of this work

The synthesis of (<i>Z</i>)-4-oxo-4-(arylamino)but-2-enoic acids derivatives and determination of their inhibition properties against human carbonic anhydrase I and II isoenzymes

<p>The synthesis of (<i>Z</i>)-4-oxo-4-(arylamino)but-2-enoic acid (<b>4</b>) derivatives containing structural characteristics that can be used for the synthesis of several active molecules, is presented. Some of the butenoic acid derivatives (<b>4a</b>, <b>4c</b>, <b>4e</b>, <b>4i</b>, <b>4j</b>, <b>4k</b>) are synthesized following literature procedures and at the end of the reaction. In addition, structures of all synthesized derivatives (<b>4a</b>–<b>4m</b>) were determined by ¹H-NMR, ¹³C-NMR and IR spectroscopy. Carbonic anhydrase is a metalloenzyme involved in many crucial physiologic processes as it catalyzes a simple but fundamental reaction, the reversible hydration of carbon dioxide to bicarbonate and protons. Significant results were obtained by evaluating the enzyme inhibitory activities of these derivatives against human carbonic anhydrase hCA I and II isoenzymes (hCA I and II). Butenoic acid derivatives (<b>4a</b>–<b>4m</b>) strongly inhibited hCA I and II with <i>K</i>_is in the low nanomolar range of 1.85 ± 0.58 to 5.04 ± 1.46 nM against hCA I and in the range of 2.01 ± 0.52 to 2.94 ± 1.31 nM against hCA II.</p