International cohort study for pediatric Behçet’s Disease: update 2011

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From Acting What’s next to Speeding Trap: Co-Evolutionary Dynamics of an Emerging Technology-Leader

JEL Classifications: O33, O53, L63[[abstract]]How does technological innovation emerge and evolve? We approach such an inquiry by synthesizing the perspectives of dynamic capabilities and co-evolutionary dynamics to portray organizational routines and multi-phase strategic renewals of an emerging technology-leader. To untangle the emergence of technological innovation, we conducted a longitudinal case study on the first and the largest dedicated semiconductor foundry, TSMC, located in the emerging economy of Taiwan. The firm-case of TSMC illustrates two unique co-evolutionary paths, that is, transforming from industry-latecomer to technology-leader and from process innovation to product innovation. We found multi-motor co-evolutionary dynamics between TSMC and the semiconductor industry, where its co-evolutionary mechanism of managed selection in its creating phase of mature process-innovation (1987-1998) has migrated to hierarchical renewal in its extending phase of advanced process-innovation (1999-2001), and then to holistic renewal in its modifying phase of product-innovation (2002-2007). During such paths, our research discovered a unique type of organizational routines, acting what’s next because TSMC has proactively searched for potential problems sooner than its competitors. However, such routines, although driving technological innovation, also lead to a unique type of success-trap, that is, speeding trap. When an emerging technology-leader fundamentally changes the industrial structures to over-specs, the growth driven by technology speeding may trap such a leader in a loop of over-exploration.[[sponsorship]]The authors are grateful to the research grant from the National Science Council (NSC) in Taiwan. The earlier manuscript of this paper was presented at the 2009 Annual Meeting of Academy of International Business (AIB) in San Diego, USA.[[notice]]補正完畢[[journaltype]]國外[[ispeerreviewed]]Y[[booktype]]紙本[[booktype]]電子版[[countrycodes]]CA

The discovAIR project:a roadmap towards the Human Lung Cell Atlas

The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The lung biological network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and the cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework program. DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions

The Prevalence of degenerative radiographic findings in the small tarsal joints of two-year-old warmblood stallions and the development of these findings over five to sixteen months

For the equine veterinarian, it is often difficult to interpret degenerative radiographic changes in the small tarsal joints of clinically healthy young horses on sales or prepurchase radiographs. The aim of this study was to expand the knowledge in this area by investigating the prevalence and progression of degenerative radiographic findings of the small tarsal joints in a homogenous population of young horses. For this purpose, the first part of the study comprised the radiographic examination of 292 two-year-old, clinically healthy and untrained Warmblood stallions to determine the prevalence of radiographic degenerative changes in the small tarsal joints. The second part of the study assessed the development of such degenerative changes over five to sixteen months. This time period is relevant for the public sale or stallion approval preparation of the horses. Follow-up radiographs of 77 stallions with degenerative changes were taken and evaluated to monitor the development of these changes over time. A standardized evaluation of the radiographs was guaranteed by a detailed evaluation scheme and three experienced and specifically qualified investigators. Our hypotheses were: a. Degenerative radiologic findings in the small tarsal joints have a high prevalence even in young and clinically healthy horses, b. Such radiologic changes can be dynamic over a short period of time. In the first part of the study, 22.6% of the stallions showed radiologic changes consistent with degenerative joint disease. There were osteophytes in the distal intertarsal and/or tarsometatarsal joint in 15.4%, areas of reduced radiopacity in the central tarsal or third tarsal bone in 6.5%, narrowing of the joint space of the distal intertarsal and/or tarsometatarsal joint in 0.3%, and sclerosis at the distal intertarsal joint in 0.7% of the horses. Dorsoproximal spurs at the third metatarsal bone were observed in 27.4% of horses; this was the most common radiologic finding. However, this finding alone did not result in the radiologic diagnosis of degenerative joint disease. In part two of the study, there was a tendency for progression of the findings “spur at third metatarsal bone” and “osteophytes at distal intertarsal and/or tarsometatarsal joint” over time. The finding “areas of reduced radiopacity in the central tarsal or third tarsal bone” appeared to be regressive over time. While the progression of spurs and osteophytes was expected as described in the literature, there was an unexpected regressive dynamic of areas of reduced radiopacity in the small tarsal bones. In the literature, these changes have been interpreted as lytic areas and as a sign of degenerative joint disease. A regression of bone lysis secondary to degenerative joint disease is not described in the literature and seems not plausible. However, it is possible that such areas of reduced radiopacity in the small tarsal bones are due to a delayed increase in bone density in young horses – such areas could really be regressive due to the significant potential for bone remodelling, especially in young animals. Results of our study confirm the high prevalence of degenerative radiographic changes of the small tarsal joints even in young, untrained and clinically healthy Warmblood stallions. However, areas of reduced radiopacity in the small tarsal bones can be regressive over a short period of time and should be evaluated cautiously concerning the radiologic diagnosis of degenerative joint disease

Laryngeal dyskinesia in a horse

A 3‐year‐old Warmblood gelding was evaluated for intermittent respiratory distress and an inspiratory noise. These signs were mainly observed at exercise but sometimes occurred at rest as well. At the age of 2 months, a severe episode of respiratory distress had necessitated a temporary tracheotomy, which had then healed uneventfully. Examination of the patient and resting endoscopy revealed no structural laryngeal alterations. Exercise endoscopy revealed episodes of active bilateral laryngeal adduction during inspiration. Spirometrically, a corresponding impairment of inspiratory airflow was identified. These abnormalities were most pronounced at the trot but they occurred at magnitudes of inspiratory airflow lower than those inducing dynamic arytenoid collapse in horses with recurrent laryngeal neuropathy. Therefore, the diagnosis of a laryngeal dyskinesia characterised by an active bilateral arytenoid adduction during inspiration was made. No specific treatment was implemented. Three years later, the owner reported that the condition was markedly improved and the horse was used for pleasure ridin