367 research outputs found
Prediction of the partition coefficient between air and body compartments from the chemical structure
Online-Bestimmungshilfe für Schadorganismen für das Internetportal www.oekolandbau.de
Organic plant protection can be supported by diagnostic aids for pest organisms. A concept for a user-friendly, scientifically founded diagnostic aid for agriculturally
relevant pest organisms is presented, which is based on a flexible filter structure and conclusive images. To provide practical information on biology and regulation options
along with the diagnosis, recent scientific results and market availability of regulation options in organic farming are being reviewed. The on-going research and transfer
project has launched the first section on storage pests in 2016 at: www.oekolandbau.de/erzeuger/pflanzenbau/allgemeiner-pflanzenbau/pflanzenschut
Disseminated Toxoplasmosis in a Patient with Non-Hodgkin Lymphoma
Abstract : Toxoplasmosis is a well-recognized opportunistic disease in HIV-infected individuals that is caused by the reactivation of a previous infection, primarily in the central nervous system, during profound immunodeficiency. Toxoplasmosis has been described more rarely in patients with cancer and chemotherapy. We report a case of a patient with a history of chemotherapy for non-Hodgkin lymphoma who developed pain and progressive paresthesia of the right arm 6 weeks after remission. Relapsing lymphoma was suspected, and steroid and radiation treatment were initiated, but the patient died 5 days later due to multiple organ failure. Autopsy revealed disseminated toxoplasmosis. This case illustrates that toxoplasmosis should be suspected in patients with neoplastic disease, especially lymphomas, who present with unexplained neurologic, pulmonary, or febrile symptoms during or after chemotherap
Dewetting of thin films on heterogeneous substrates: Pinning vs. coarsening
We study a model for a thin liquid film dewetting from a periodic
heterogeneous substrate (template). The amplitude and periodicity of a striped
template heterogeneity necessary to obtain a stable periodic stripe pattern,
i.e. pinning, are computed. This requires a stabilization of the longitudinal
and transversal modes driving the typical coarsening dynamics during dewetting
of a thin film on a homogeneous substrate. If the heterogeneity has a larger
spatial period than the critical dewetting mode, weak heterogeneities are
sufficient for pinning. A large region of coexistence between coarsening
dynamics and pinning is found.Comment: 4 pages, 4 figure
A Prospective Multicenter SPOG 2003 FN Study of Microbiologically Defined Infections in Pediatric Cancer Patients with Fever and Neutropenia.
BACKGROUND: Fever and neutropenia (FN) often complicate anticancer treatment and can be caused by potentially fatal infections. Knowledge of pathogen distribution is paramount for optimal patient management.
METHODS: Microbiologically defined infections (MDI) in pediatric cancer patients presenting with FN by nonmyeloablative chemotherapy enrolled in a prospective multi-center study were analyzed. Effectiveness of empiric antibiotic therapy in FN episodes with bacteremia was assessed taking into consideration recently published treatment guidelines for pediatric patients with FN.
RESULTS: MDI were identified in a minority (22%) of pediatric cancer patients with FN. In patients with, compared to without MDI, fever (median, 5 [IQR 3-8] vs. 2 [IQR1-3] days, p < 0.001) and hospitalization (10 [6-14] vs. 5 [3-8] days, p < 0.001) lasted longer, transfer to the intensive care unit was more likely (13 of 95 [14%] vs. 7 of 346 [2.0%], p < 0.001), and antibiotics were given longer (10 [7-14] vs. 5 [4-7], p < 0.001). Empiric antibiotic therapy in FN episodes with bacteremia was highly effective if not only intrinsic and reported antimicrobial susceptibilities were considered but the purposeful omission of coverage for coagulase negative staphylococci and enterococci was also taken into account (81% [95%CI 68 - 90] vs. 96.6% [95%CI 87 - 99.4], p = 0.004) CONCLUSIONS: MDI were identified in a minority of FN episodes but they significantly affected management and the clinical course of pediatric cancer patients. Compliance with published guidelines was associated with effectiveness of empiric antibiotic therapy in FN episodes with bacteremia
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