Cerebral Venous Sinus Thrombosis as a Rare Complication of Systemic Lupus Erythematosus: Subgroup Analysis of the VENOST Study

Aim: Systemic lupus erythematosus (SLE) is an unusual risk factor for cerebral venous sinus thrombosis (CVST). As few CVST patients with SLE have been reported, little is known regarding its frequency as an underlying etiology, clinical characteristics, or long-term outcome. We evaluated a large cohort of CVST patients with SLE in a multicenter study of cerebral venous thrombosis, the VENOST study, and their clinical characteristics. Material and Method: Among the 1144 CVST patients in the VENOST cohort, patients diagnosed with SLE were studied. Their demographic and clinical characteristics, etiological risk factors, venous involvement status, and outcomes were recorded. Results: In total, 15 (1.31%) of 1144 CVST patients had SLE. The mean age of these patients was 39.9 ± 12.1 years and 13 (86.7%) were female. Presenting symptoms included headache (73.3%), visual field defects (40.0%), and altered consciousness (26.7%). The main sinuses involved were the transverse (60.0%), sagittal (40.0%), and sigmoid (20.0%) sinuses. Parenchymal involvement was not seen in 73.3% of the patients. On the modified Rankin scale, 92.9% of the patients scored 0-1 at the 1-month follow-up and 90.9% scored 0-1 at the 1-year follow-up. Conclusions: SLE was found in 1.31% of the CVST patients, most frequently in young women. Headache was the most common symptom and the CVST onset was chronic in the majority of cases. The patient outcomes were favorable. CVST should be suspected in SLE patients, even in those with isolated chronic headache symptoms with or without other neurological findings. © 2019 Elsevier Inc

A tabu search algorithm for the traveling purchaser problem with transportation time limit

Bu çalışma, 06-08, Eylül 2023 tarihlerinde Berlin[Almanya]’da düzenlenen 14. International Conferences on Computational Logistics (ICCL) Kongresi‘nde bildiri olarak sunulmuştur.This study extends the well-known traveling purchaser problem (TPP) by considering a transportation time limit of perishable food in cold-chain logistics. The problem is called the traveling purchaser problem with transportation time limit (TPP-TTL). The objective of the TPP-TTL is to find a route and procurement plan for the purchaser to satisfy the demand of a number of product types with minimum cost. To satisfy the product demand, the purchaser visits a number of capacitated markets, in which the available amount of products is limited. Furthermore, since the travel times cause deterioration on the perishable products, a transportation time limit is taken into account in the TPP-TTL for each product type. The problem is formulated as a mixed-integer programming model and solved by using a tabu search (TS) algorithm. In the computational experiments, TS is carried out for a number of different-sized instances and the results are compared to the results obtained by GUROBI solver to determine the performance of the proposed algorithm. The results of the experiments show that the TS is capable to find many optimal results with less computational time than the GUROBI solver