The protective effect of intratympanic alpha lipoic acid on cisplatin-induced Ototoxicity on rats

OBJECTIVE: The objective of this study is to investigate the effect of intratympanic alpha lipoic acid (alpha-LA) on cisplatin-induced ototoxicity by using distortion product otoacoustic emission (DPOAE)

Effect of transtympanic injection of melatonin on cisplatin-induced ototoxicity

OBJECTIVE: Cisplatin is a chemotherapeutic agent that is widely used in cancer treatment. Numerous side effects have been detected, one of which is ototoxicity. Melatonin, a product of the pineal gland, has a neuroendocrinoimmunological role in vertebrates. In the present study, we investigated the effects of melatonin on cisplatin-induced ototoxicity

Oxytocin as a protective agent in cisplatin-induced ototoxicity

Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during pregnancy, has antioxidant and antiinflammatory effect. Our study aims to test and compare the effect of intratympanic (IT) and intraperitoneal (IP) oxytocin on cisplatin ototoxicity with DPOAE