868 research outputs found
A Rare Presentation of Crohn's Disease
Free peritoneal perforation is a rare complication of Crohn's disease with a report of only 100 cases in the literature. It needs an emergency exploration and an unaware general surgeon is confounded in intraoperative decision-making. We present our experience when this rarity struck us in a district hospital and briefly review the guidelines of optimal management of this complication of Crohn's disease
Family Relations in Manushyaputra's Poems
The individual society is bound by the rope of the family. Human relationships begin from the single point of the family. Society is the entire group of families. Basically, the family consists of two relationships, husband and wife. Later on, the blood of the two expands into the system of continuous son and daughter. Moreover, all those who live around in families belong to family relationships. When did the system of the family appear in relationships? Research to find an answer to the question is continuing. The family system must have arisen only after the emergence of human beings. Thus, in the poems of Manushyaputran, the study of this article is only a summary of the pattern of affection in family relations and some of the changes that take place in it
AZIMA TETRACANTHA LAM. AGAINST CAUSATIVE AGENTS IN DIABETIC FOOT INFECTIONS
Objective: Azima tetracantha Lam.  (Salvadoraceae), a widely growing herb has been used in the traditional medicine for treating many ailments. The objective of the present study was to evaluate the antimicrobial activity of aqueous extract of A. tetracantha leaves (AEAT) against the causative agents in diabetic foot infections and to understand the major phyto-constituents.Methods: Susceptibility analysis was carried out by disc diffusion method at two different concentrations of AEAT ‘viz' 500 &1000 µg/ml. UHPLC-ESI MS/MS was carried over with C18 RP column using gradient mobile system and the spectrum obtained was interpreted.Results: All the strains tested were more susceptible to AEAT with maximum of 15mm inhibition observed for Aspergillus niger and Klebseilla pneumoniae. UHPLC-ESI MS/MS study confirmed the presence of Isorhamnetin-3-O-rutinoside, Myricetin and Friedelin in AEAT.Conclusion: To conclude AEAT is found to be a good source of lead compounds in diabetic foot infections.  KEYWORDS Azima tetracantha, UHPLC ESI-MS/MS, antimicrobia
The leaf-feeding geometrid Isturgia disputaria (Guenee)-A potential biological control agent for prickly acacia, Vachellia nilotica subsp. indica (Benth.) Kyal. & Boatwr. (Mimosaceae) in Australia
Prickly acacia (Vachellia nilotica subsp. indica), a native multipurpose tree in India, is a weed of National significance, and a target for biological control in Australia. Based on plant genetic and climatic similarities, native range surveys for identifying potential biological control agents for prickly acacia were conducted in India during 2008-2011. In the survey leaf-feeding geometrid, Isturgia disputaria Guenee (syn. Tephrina pulinda), widespread in Tamil Nadu and Karnataka States, was prioritized as a potential biological control agent based on field host range, damage potential and no choice test on non target plant species. Though the field host range study exhibited that V. nilotica ssp. indica and V. nilotica ssp. tomentosa were the primary hosts for successful development of the insect, I. disputaria, replicated no - choice larval feeding and development tests conducted on cut foliage and live plants of nine non-target acacia test plant species in India revealed the larval feeding and development on three of the nine non-target acacia species, V. tortilis, V. planiferons and V. leucophloea in addition to the V. nilotica ssp. indica and V. nilotica ssp. tomentosa. However, the proportion of larvae developing into adults was higher on V. nilotica subsp. indica and V. nilotica subsp. tomentosa, with 90% and 80% of the larvae completing development, respectively. In contrast, the larval mortality was higher on V. tortilis (70%), V. leucophloea (90%) and V. planiferons (70%). The no-choice test results support the earlier host specificity test results of I. disputaria from Pakistan, Kenya and under quarantine in Australia. Contrasting results between field host range and host use pattern under no-choice conditions are discussed
Computational evaluation of small molecule inhibitors of RGS4 to regulate the dopaminergic control of striatal LTD
Parkinson’s disease is a neurodegenerative disease which is the result of the degradation of the dopaminergic neurons in the substantia nigra pars compacta, leading to a disregulation of thalamocortical circuits. Traditional treatment involves the use of levodopa which increases the dopamine level in the striatum. There is a need for alternative non-dopamine therapy to prevent the side effects of the conventional drugs used. Recently small molecule inhibitors of RGS have become the prime candidates in studies related to regulating RGS by binding to its allosteric site and thus changing its structure. Through the docking studies we observed that these small molecule modulators of RGS4 make stable complexes with RGS4 when compared to native RGS4. The Gq(alpha)–GS4–rug complexes are less stable. The increase in flexibility of the RGS4–rug complex could be the reason for the inability of the RGS4–rug complex to bind to the G protein. In our docking results, CCG63802 formed the most promising drug as a RGS4 inhibitor as it formed the most stable complex with RGS4 and also formed the least stable complex, Gq(alpha)–RGS4–CCG63802 complex. In our studies we evaluated the therapeutic potential of the small molecule inhibitors to provide a prospective treatment for Parkinson’s disease.Keywords: RGS4 inhibitor; Parkinson disease; Flexibility; MGlu receptors; Neural plasticityThe Egyptian Journal of Medical Human Genetics (2013) 14, 135–14
The leaf-feeding geometrid Isturgia disputaria (Guenee)-A potential biological control agent for prickly acacia, Vachellia nilotica subsp. indica (Benth.) Kyal. & Boatwr. (Mimosaceae) in Australia
Prickly acacia (Vachellia nilotica subsp. indica), a native multipurpose tree in India, is a weed of National significance, and a target for biological control in Australia. Based on plant genetic and climatic similarities, native range surveys for identifying potential biological control agents for prickly acacia were conducted in India during 2008-2011. In the survey leaf-feeding geometrid, Isturgia disputaria Guenee (syn. Tephrina pulinda), widespread in Tamil Nadu and Karnataka States, was prioritized as a potential biological control agent based on field host range, damage potential and no choice test on non target plant species. Though the field host range study exhibited that V. nilotica ssp. indica and V. nilotica ssp. tomentosa were the primary hosts for successful development of the insect, I. disputaria, replicated no - choice larval feeding and development tests conducted on cut foliage and live plants of nine non-target acacia test plant species in India revealed the larval feeding and development on three of the nine non-target acacia species, V. tortilis, V. planiferons and V. leucophloea in addition to the V. nilotica ssp. indica and V. nilotica ssp. tomentosa. However, the proportion of larvae developing into adults was higher on V. nilotica subsp. indica and V. nilotica subsp. tomentosa, with 90% and 80% of the larvae completing development, respectively. In contrast, the larval mortality was higher on V. tortilis (70%), V. leucophloea (90%) and V. planiferons (70%). The no-choice test results support the earlier host specificity test results of I. disputaria from Pakistan, Kenya and under quarantine in Australia. Contrasting results between field host range and host use pattern under no-choice conditions are discussed
PCV15 COMBINED OPTIMAL LIPID VALUE GOAL ATTAINMENT AFTER TREATMENT INITIATION WITH SIMVASTATIN PLUS NIACIN EXTENDED-RELEASE COMBINATION THERAPY VERSUS EZETIMIBE PLUS SIMVASTATIN COMBINATION THERAPY IN A MANAGED CARE PATIENT POPULATION WITH PRIOR CARDIOVASCULAR DISEASE IN THE UNITED STATES
The Effectiveness of Engineering Design in Developing Engineering Habits of Mind among Eight Grade Students in Sultanate of Oman
This research investigates the effect of engineering design on the development of the engineering habits of mind among eighth grade students in the Sultanate of Oman. The study adopted the semi-experimental research design. The study sample had two experimental groups; the first group (23 students) was enrolled in a special program of engineering design; and the second group was a control group (25 students) which had not participated in any engineering design programs. The quantitative results revealed statistically significant differences at the level of significance ( Â between the performance of students of the two groups in identifying problem habits, optimization and development, and system thinking in favour of the experimental group in the scale of the habits of the engineering mind. However, there were no statistically significant differences between the performance of the two groups in the habits of visualizing, creativity in problem solving, and adaptation. Analysis of qualitative data reached similar findings. Taken together, these findings suggest a set of recommendations, including the integration of engineering design into science curricula for contribution to the development of engineering habits of mind. Further surveyed studies can be conducted to discover the most common engineering habits of mind among students of all stages in the study
Anthelminthic activity of Asta Churna
Purpose: To determine the effect of Asta churna (an
ayurvedic preparation of Impcops) on Indian
earthworms. Methods: Asta churna (2.5 mg/mL and 5 mg/mL) were investigated for activity in Indian earthworms (Pheretima postuma) against piperazine citrate (15 mg/mL) and albendazole (20 mg/mL) as standard references and normal saline as control. The time to achieve paralysis of the worms was determined. Results: The two concentrations of Asta churna exhibited significant anthelminthic activity (p < 0.001) when compared with the piperazine citrate, albendazole and normal saline. Conclusion: Asta chuma has paralytic effect on Indian earthworms.
Keywords: Asta churna, Pheretima postuma, Anthelminthic activit
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