Clinical and radiological features of nonfamilial cherubism : a case report

Background: Cherubism is an uncommon hereditary benign fibro-osseous disorder characterized by bilateral enlargement of the mandible and the maxilla that presents with varying degrees of involvement and a tendency toward spontaneous remission. On radiography cherubic lesions appear as cystic multilocular radiolucencies limited to the jaw bones. Case Report: A 5-year-old boy was referred to the Department of Maxillo-Facial Surgery due to deformation of the lower and middle section of the face and displacement or absence of teeth. A panoramic radiograph and a computed tomography revealed extensive multilocular, bilateral radiolucent areas and marked bony expansion in the mandible and maxilla, with sparing of the mandibular condyles. Histopathological evaluation of an incisional biopsy of the left maxilla and genotypic characterization confirmed the diagnosis of cherubism. Conclusions: The radiologic characteristics of cherubism are not pathognomonic but the diagnosis is strongly suggested by bilateral relatively symmetric jaw involvement that is limited to the jaw bones and, together with clinical and histopathologic findings, enables the diagnosis of cherubism. Genotypic characterization confirms the diagnosis

Wklinowanie do otworu wielkiego w przebiegu zapalenia móżdżku u 4-letniego chłopca w obrazie TK i MR : opis przypadku

Background: Acute cerebellitis is an uncommon but dangerous complication of infectious diseases. Besides neurological examination, neuroimaging (especially MR imaging) is very useful for diagnosing cerebellitis. Case Report: A 4-year-old boy was admitted to the hospital with a 1-week history of fever, vomiting and headache. His past medical history was unremarkable. The physical examination revealed disturbance of consciousness and truncal ataxia. He underwent urgent CT and MRI examinations which demonstrated isolated swelling of the cerebellar hemispheres and the vermis, with increased signal intensity in T2-weighted, FLAIR, and DWI sequence and a significant mass effect associated with tonsillar herniation. An emergent life-saving suboccipital craniectomy was performed with removal of the C1 vertebral arch. There was a gradual clinical improvement, and a follow-up brain MRI revealed disappearance of cerebellar swelling and of mass effect. Conclusions: Magnetic resonance (MR), including diffusion-weighted imaging (DWI) sequence, plays an important role in the diagnostic work-up of cerebellitis in children. This imaging method is very useful for detecting cerebellitis, evaluating its severity and monitoring the disease

Statistical, Morphometric, Anatomical Shape Model (Atlas) of Calcaneus

<div><p>The aim was to develop a morphometric and anatomically accurate atlas (statistical shape model) of calcaneus. The model is based on 18 left foot and 18 right foot computed tomography studies of 28 male individuals aged from 17 to 62 years, with no known foot pathology. A procedure for automatic atlas included extraction and identification of common features, averaging feature position, obtaining mean geometry, mathematical shape description and variability analysis. Expert manual assistance was included for the model to fulfil the accuracy sought by medical professionals. The proposed for the first time statistical shape model of the calcaneus could be of value in many orthopaedic applications including providing support in diagnosing pathological lesions, pre-operative planning, classification and treatment of calcaneus fractures as well as for the development of future implant procedures.</p></div

Correlation between the SPHARM coefficients of the left and the right calcaneus.

<p>Linear correlation is performed on the reduced set of coefficients excluding the three highest coefficients (see inset).</p

The process of building the morphometric and anatomical atlas of calcaneus.

<p>Hand icon denotes manual or semi-manual assisted processing lead by an experienced operator. Arrows icon denotes two isometric operations (translation and rotation) of the shape. Steps A to H are described in detail Section 2B.</p

An example of reconstructed SSM of right calcaneus using (from left to right) the 25th, 50th and 75th quartile of the spherical harmonic coefficients.

<p>An example of reconstructed SSM of right calcaneus using (from left to right) the 25th, 50th and 75th quartile of the spherical harmonic coefficients.</p

Additional file 1 of Statistical shape models of cuboid, navicular and talus bones

SPHARM coefficients for calcaneus, cuboid, navicular and talus bones. (XLS 127 KB