Mężczyźni bezdomni o aktywnościach codziennych: Etnograficzne studia przypadków

Niniejszy artykuł stanowi etnograficzne studia przypadków aktywności codziennych podejmowanych przez 4 bezdomnych mężczyzn w wieku 52–72 lat, zamieszkujących w schronisku. Pytaniem badawczym, postawionym w niniejszym raporcie z badań, było: jakie aktywności codzienne podejmują bezdomni mężczyźni? Gromadzenie danych odbywało się telefonicznie w maju 2020 roku w czasie pandemii Covid-19 w Polsce. Dane analizowano techniką kodowania i kategoryzacji [Gibbs 2011]. Wyniki badań pozwoliły na ustalenie kategorii głównej – aktywności codziennych oraz 3 podkategorii: struktury aktywności codziennych, aktywności sprawiające przyjemności oraz aktywności związane z obowiązkami w schronisku. Oprócz tego, wyniki badań wskazały również pewna nieproporcjonalność czasu aktywności codziennych (zajęć, prac) w stosunku do czasu wolnego, który jest przyczyną odczuwanej monotonii, przez bezdomnych mężczyzn

Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.

Statins are widely used to lower plasma concentrations of lipids, e.g. cholesterol. One of the main effects of statin treatment is inhibition of hydroxymethyl glutaryl-coenzyme A reductase. The role of fluvastatin, a frequently used statin, was examined in potential modulation of tyrosinase (key enzyme of melanogenesis) synthesis. Levels of tyrosinase mRNA induced by UVB irradiation of B16F10 melanoma cell line were measured by real time PCR. Fluvastatin increases tyrosinase mRNA production induced by UVB irradiation in B16F10 melanoma cell line. Fluvastatin treatment may potentially influence melanin synthesis and protection against UV irradiation

Differences in lifestyle between students of medical and biological fields of study in Poland

Students are a specific social group characterized by different lifestyle behaviours.The aim of the study was to determine whether there are lifestyle differences between students of medical and biological fields from three different universities in Poland.The research material consisted of answers from 1163 students (781 women and 382 men), aged 17.5– 26.0 from the medical faculty of the Wroclaw Medical University, biological faculties of the Cardinal Stefan Wyszynski University in Warsaw and the University of Lodz. The survey included questions regarding gender, socio-demographic situation, lifestyle and eating habits. Students also provided height and weight data, which was used for BMI calculation. Chi-square test and one-way ANOVA were used to indicate differences in BMI between students and to estimate differences in lifestyle between students from three different university centres.Medical students exhibited significantly lower BMI values compared to students from other academic centres. They also more often reported doing additional sports and assessed their overall level of physical activity significantly higher compared to students from other academic centres. Biology students reported to sleep longer and being more exhausted compared to medical students. Biology students tended to drink sugar-sweetened beverages and eat fast-food significantly more often than medical students. Students from the medical faculty in Wroclaw reported to smoke cigarettes less often compared to students from non-medical study. There were no significant differences in other studied factors, such as the use of alcohol, snacking between the meals and consumption of energy drinks.Overall, students of medical fields reported a healthier lifestyle compared to their peers from biological faculties, although this was not consistent for all examined factors

Homeless males on daily activities: Ethnographic case studies

Niniejszy artykuł stanowi etnograficzne studia przypadków aktywności codziennych podejmowanych przez 4 bezdomnych mężczyzn w wieku 52–72 lat, zamieszkujących w schronisku. Pytaniem badawczym, postawionym w niniejszym raporcie z badań, było: jakie aktywności codzienne podejmują bezdomni mężczyźni? Gromadzenie danych odbywało się telefonicznie w maju 2020 roku w czasie pandemii Covid-19 w Polsce. Dane analizowano techniką kodowania i kategoryzacji [Gibbs 2011]. Wyniki badań pozwoliły na ustalenie kategorii głównej – aktywności codziennych oraz 3 podkategorii: struktury aktywności codziennych, aktywności sprawiające przyjemności oraz aktywności związane z obowiązkami w schronisku. Oprócz tego, wyniki badań wskazały również pewną nieproporcjonalność czasu aktywności codziennych (zajęć, prac) w stosunku do czasu wolnego, który jest przyczyną odczuwanej monotonii, przez bezdomnych mężczyzn.This article is an ethnographic case studies report of daily activities undertaken by 4 homeless males aged 52–72 living in the shelter. The research question posed in this research report was: what daily activities do homeless males undertake? Data collection was carried out by phone in May 2020 during the Covid-19 pandemic in Poland. Data was analyzed by coding and categorization [Gibbs 2011]. The results of the research allowed to establish the main category - everyday activities and 3 subcategories: the structure of everyday activities, activities giving pleasure and activities related to duties in the shelter. In addition, the results of the study also indicated a certain disproportionate amount of daily activities (activities, work) in relation to free time, which is the cause of monotony experienced by homeless male

The Influence of Socioeconomic Factors on the Body Characteristics, Proportion, and Health Behavior of Children Aged 6–12 Years

Background: The research aimed to determine how socioeconomic factors influence the body structure and health behaviors of children in a suburban commune. Methods: Data from 376 children aged 6.78 to 11.82 years from Jabłonna, Poland, were analyzed. A questionnaire was used to gather information regarding the socioeconomic status and dietary habits of these children, and physical measurements such as height, weight, pelvic width, shoulder width, chest, waist, hip, and arm circumferences, and three skinfolds were taken. Hip index, pelvi-acromial index, Marty’s index, BMI (body mass index), WHR (waist–hip ratio), and the sum of three skinfolds were calculated. One-way analysis of variance, Student’s t-test, and X2 test with p 0.05 were used. Results: The size of the family and the level of education and occupation of the fathers had a significant impact on the body proportions of the children. Children from larger centers with more educated parents were seen to have healthier eating habits and higher levels of physical activity, and their parents were less likely to smoke cigarettes. Conclusions: It was concluded that the development environment of the parents, such as their level of education and profession, play a more important role than the size of birthplace

Salivary IL-17A, IL-17F, and TNF-α Are Associated with Disease Advancement in Patients with Oral and Oropharyngeal Cancer

Delayed diagnosis of oral cavity and oropharyngeal cancer is associated with a poor prognosis. Despite progress in systemic therapy and radiotherapy, there has only been a slight improvement in the five-year survival rate. A non-invasive diagnostic method that consists of an assessment of specific proteins in saliva samples may significantly facilitate assessment of treatment results in patients diagnosed with oral and oropharyngeal cancer. The aim of this study was to assess the levels of IL-17 and TNF-α in the saliva of patients with oral and oropharyngeal cancer. The study was conducted prior to treatment in patients hospitalized in the Frederic Chopin Provincial Specialist Hospital No. 1 in Rzeszów, Poland. Saliva samples were collected from subjects on an empty stomach. Cytokine concentrations in the saliva were measured with ELISA and Luminex Multiplex Assays. The higher salivary concentrations of IL-17A, IL-17F, and TNF-α were significantly associated with disease advancement. Lower levels of IL-17A were associated with colonization of the oral cavity with aerobic bacteria. On the other hand, higher concentration of TNF-α was observed in patients with positive aerobic culture of oral swabs. Our results suggest that IL-17A, IL-17F, and TNF-α measured in the saliva may be a potential biomarker for cancer of the oral cavity and oropharynx

LncCDH5-3:3 Regulates Apoptosis, Proliferation, and Aggressiveness in Human Lung Cancer Cells

(1) Lung cancer (both small cell and non-small cell) is the leading cause of new deaths associated with cancers globally in men and women. Long noncoding RNAs (lncRNAs) are associated with tumorigenesis in different types of tumors, including lung cancer. Herein, we discuss: (1) An examination of the expression profile of lncCDH5-3:3 in non-small cell lung cancer (NSCLC), and an evaluation of its functional role in lung cancer development and progression using in vitro models; (2) A quantitative real-time polymerase chain reaction assay that confirms lncCDH5-3:3 expression in tumor samples resected from 20 NSCLC patients, and that shows its statistically higher expression levels at stage III NSCLC, compared to stages I and II. Moreover, knockout (KO) and overexpression, as well as molecular and biochemical techniques, were used to investigate the biological functions of lncCDH5-3:3 in NSCLC cells, with a focus on the cells’ proliferation and migration; (3) The finding that lncCDH5-3:3 silencing promotes apoptosis and probably regulates the cell cycle and E-cadherin expression in adenocarcinoma cell lines. In comparison, lncCDH5-3:3 overexpression increases the expression levels of proliferation and epithelial-to-mesenchymal transition markers, such as EpCAM, Akt, and ERK1/2; however, at the same time, it also stimulates the expression of E-cadherin, which conversely inhibits the mobility capabilities of lung cancer cells; (4) The results of this study, which provide important insights into the role of lncRNAs in lung cancer. Our study shows that lncCDH5-3:3 affects important features of lung cancer cells, such as their viability and motility. The results support the idea that lncCDH5-3:3 is probably involved in the oncogenesis of NSCLC through the regulation of apoptosis and tumor cell metastasis formation