Adolescent Athletes’ Perspectives on the Social Implications of Sport-Related Concussion

Purpose: Sport-related concussion can affect many domains of a patient’s health status. Social functioning is an important consideration, especially for adolescent athletes. Our purpose was to explore adolescent athletes’ social perspectives regarding sport and concussion. Methods: Using a qualitative study design we interviewed 12 interscholastic athletes who had sustained a sport-related concussion. The interviews focused on injury details, and explored the physical, psychosocial, emotional, and spiritual components of sport and health. Themes and categories were identified using the consensual qualitative research process by a three-person research team. A comprehensive codebook that captured the main themes and categories resulted. Results: Following concussion, participants discussed two primary themes: perceptions regarding the social aspects of sport and social perspectives regarding their concussion. Specific categories related to the social aspects of sport included: friendships and family and decision to participate based on peers. Specific categories regarding the social perspectives of the concussion included uncertainty of the diagnosis, perceptions of others regarding their injury, being ashamed of the concussion, parent and peer roles, and communication and expectation about their concussion. Conclusions: Participation in sport and removal from sport following a concussion have significant social implications for adolescent athletes. Specifically, the perceptions of peers, parents/guardians, and others regarding the injury can influence reporting of symptoms and recovery following concussion. Limited communication regarding recovery and expectations post-concussion may cause undue social pressures to return to activity prematurely. Providing a supportive environment in which patients can recover from concussion while engaging with peers and teammates is important. Anticipatory guidance, with education regarding the possible signs and symptoms, risk factors pre- and post-injury, and recovery expectations following a concussion are important to include in post-injury management and should be known to all stakeholders

Weak Lensing from Space III: Cosmological Parameters

Weak gravitational lensing provides a unique method to directly map the dark matter in the universe and measure cosmological parameters. Current weak lensing surveys are limited by the atmospheric seeing from the ground and by the small field of view of existing space telescopes. We study how a future wide-field space telescope can measure the lensing power spectrum and skewness, and set constraints on cosmological parameters. The lensing sensitivity was calculated using detailed image simulations and instrumental specifications studied in earlier papers in this series. For instance, the planned SuperNova/Acceleration Probe (SNAP) mission will be able to measure the matter density parameter Omega_m and the dark energy equation of state parameter w with precisions comparable and nearly orthogonal to those derived with SNAP from supernovae. The constraints degrade by a factor of about 2 if redshift tomography is not used, but are little affected if the skewness only is dropped. We also study how the constraints on these parameters depend upon the survey geometry and define an optimal observing strategy.Comment: 12 pages, 11 figures. Accepted versio

SparsePak: A Formatted Fiber Field Unit for The WIYN Telescope Bench Spectrograph. I. Design, Construction, and Calibration

We describe the design and construction of a formatted fiber field-unit, SparsePak, and characterize its optical and astrometric performance. This array is optimized for spectroscopy of low-surface brightness, extended sources in the visible and near-infrared. SparsePak contains 82, 4.7" fibers subtending an area of 72"x71" in the telescope focal plane, and feeds the WIYN Bench spectrograph. Together, these instruments are capable of achieving spectral resolutions of lambda/dlambda ~ 20000 and an area--solid-angle product of ~140 arcsec^2 m^2 per fiber. Laboratory measurements of SparsePak lead to several important conclusions on the design of fiber termination and cable curvature to minimize focal ratio degradation. SparsePak itself has throughput >80% redwards of 5200 A, and 90-92% in the red. Fed at f/6.3, the cable delivers an output 90% encircled energy at nearly f/5.2. This has implications for performance gains if the WIYN Bench Spectrograph had a faster collimator. Our approach to integral-field spectroscopy yields an instrument which is simple and inexpensive to build, yet yields the highest area--solid-angle product per spectrum of any system in existence. An Appendix details the fabrication process in sufficient detail for others to repeat. SparsePak was funded by the National Science Foundation and the University of Wisconsin-Madison Graduate School, and is now publicly available on the WIYN Telescope through the National Optical Astronomical Observatories.Comment: accepted for publication in PASP; 17 pages text, 16 figures (embedded

Retrospective Review of the Patient Cases at a Major Trauma Center in Nairobi, Kenya and Implications for Emergency Care Development

Introduction Low- and middle-income countries (LMICs) are continuing to experience a “triple burden” of disease - traumatic injury, non-communicable diseases (NCDs), and communicable disease with maternal and neonatal conditions (CD&Ms). The epidemiology of this triad is not well characterised and poses significant challenges to resource allocations, administration, and education of emergency care providers. The data collected in this study provide a comprehensive description of the emergency centre at Kenya\u27s largest public tertiary care hospital. Methods This study is a retrospective chart review conducted at Kenyatta National Hospital of all patient encounters over a four-month period. Data were collected from financial and emergency centre triage records along with admission and mortality logbooks. Chief complaints and discharge diagnoses collected by specially trained research assistants were manually converted to standardised diagnoses using International Classification of Disease 10 (ICD-10) codes. ICD-10 codes were categorised into groups based on the ICD-10 classification system for presentation. Results A total of 23,941 patients presented to the emergency centre during the study period for an estimated annual census of 71,823. The majority of patients were aged 18-64 years (58%) with 50% of patients being male and only 3% of unknown sex. The majority of patients (61%) were treated in the emergency centre, observed, and discharged home. Admission was the next most common disposition (33%) followed by death (6%). Head injury was the overall most common diagnosis (11%) associated with admission. Conclusions Trends toward NCDs and traumatic diseases have been described by this study and merit further investigation in both the urban and rural setting. Specifically, the significance of head injury on healthcare cost, utilisation, and patient death and disability points to the growing need of additional resources at Kenyatta National Hospital for acute care. It further demonstrates the mounting impact of trauma in Kenya and throughout the developing world

Imbalance of Hsp70 family variants fosters tau accumulation

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154405/1/fsb2027004018.pd

How Does Information Processing Speed Relate to the Attentional Blink?

Background When observers are asked to identify two targets in rapid sequence, they often suffer profound performance deficits for the second target, even when the spatial location of the targets is known. This attentional blink (AB) is usually attributed to the time required to process a previous target, implying that a link should exist between individual differences in information processing speed and the AB. Methodology/Principal Findings The present work investigated this question by examining the relationship between a rapid automatized naming task typically used to assess information-processing speed and the magnitude of the AB. The results indicated that faster processing actually resulted in a greater AB, but only when targets were presented amongst high similarity distractors. When target-distractor similarity was minimal, processing speed was unrelated to the AB. Conclusions/Significance Our findings indicate that information-processing speed is unrelated to target processing efficiency per se, but rather to individual differences in observers' ability to suppress distractors. This is consistent with evidence that individuals who are able to avoid distraction are more efficient at deploying temporal attention, but argues against a direct link between general processing speed and efficient information selection

Speech and Non-Speech Audio-Visual Illusions: A Developmental Study

It is well known that simultaneous presentation of incongruent audio and visual stimuli can lead to illusory percepts. Recent data suggest that distinct processes underlie non-specific intersensory speech as opposed to non-speech perception. However, the development of both speech and non-speech intersensory perception across childhood and adolescence remains poorly defined. Thirty-eight observers aged 5 to 19 were tested on the McGurk effect (an audio-visual illusion involving speech), the Illusory Flash effect and the Fusion effect (two audio-visual illusions not involving speech) to investigate the development of audio-visual interactions and contrast speech vs. non-speech developmental patterns. Whereas the strength of audio-visual speech illusions varied as a direct function of maturational level, performance on non-speech illusory tasks appeared to be homogeneous across all ages. These data support the existence of independent maturational processes underlying speech and non-speech audio-visual illusory effects

Mosaic Chromosomal alterations in Blood across ancestries Using Whole-Genome Sequencing

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program. We observed higher sensitivity with whole-genome sequencing data, compared with array-based data, in uncovering mCAs at low mutant cell fractions and found that individuals of European ancestry have the highest rates of autosomal mCAs and the lowest rates of chromosome X mCAs, compared with individuals of African or Hispanic ancestry. Although further studies in diverse populations will be needed to replicate our findings, we report three loci associated with loss of chromosome X, associations between autosomal mCAs and rare variants in DCPS, ADM17, PPP1R16B and TET2 and ancestry-specific variants in ATM and MPL with mCAs in cis