DSCOVR-EPIC MAIAC AOD - A Proxy for Understanding Aerosol Diurnal Patterns from Space

The Deep Space Climate Observatory (DSCOVR) spacecraft was launched on 11 February 2015 and in June 2015 achieved its orbit at the first Lagrange point (L1), 1.5 million km from Earth toward the sun. The Earth Polychromatic Imaging Camera (EPIC) onboard DSCOVR views the entire sunlit Earth from sunrise to sunset, every 1-2 hours, at scattering angles between 168.5 and 175.5 with 10 narrowband filters in the range of 317-779 nm. NASA Multiangle Implementation of Atmospheric Correction (MAIAC) algorithm, originally developed for MODIS, has been applied to EPIC data with an Aerosol Optical Depth (AOD) product at 440nm with a 10km spatial resolution. This high temporal resolution product is a unique dataset for investigating diurnal patterns in aerosols from space. Our work analyzed the capability of the satellite-borne data to capture the aerosol diurnal variation by associating it with AERONET AOD at 440nm data over the contiguous US. We validated the DSCOVR MAIAC AOD data over 100 AERONET stations during 2015-2018, and examined the contribution of the surface reflectance and relevant acquisition angles, derived by the MAIAC algorithm, to the predicted error. We used over 180,000 hourly DSCOVR-EPIC MAIAC AOD observations with collocated with AERONET AOD observations averaged over +-30 minutes from the satellite overpass time. The AERONET and DSCOVR AOD temporal patterns show that the diurnal variation is different across US AERONET sites, with higher diurnal variation in the DSCOVR dataset in general

Estimation of hourly near surface air temperature across Israel using an ensemble model

Mapping of near-surface air temperature (Ta) at high spatio-temporal resolution is essential for unbiased assessment of human health exposure to temperature extremes, not least given the observed trend of urbanization and global climate change. Data constraints have led previous studies to focus merely on daily Ta metrics, rather than hourly ones, making them insufficient for intra-day assessment of health exposure. In this study, we present a three-stage machine learning-based ensemble model to estimate hourly Ta at a high spatial resolution of 1 × 1 km2, incorporating remotely sensed surface skin temperature (Ts) from geostationary satellites, reanalysis synoptic variables, and observations from weather stations, as well as auxiliary geospatial variables, which account for spatio-temporal variability of Ta. The Stage 1 model gap-fills hourly Ts at 4 × 4 km2 from the Spinning Enhanced Visible and InfraRed Imager (SEVIRI), which are subsequently fed into the Stage 2 model to estimate hourly Ta at the same spatio-temporal resolution. The Stage 3 model downscales the residuals between estimated and measured Ta to a grid of 1 × 1 km2, taking into account additionally the monthly diurnal pattern of Ts derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) data. In each stage, the ensemble model synergizes estimates from the constituent base learners—random forest (RF) and extreme gradient boosting (XGBoost)—by applying a geographically weighted generalized additive model (GAM), which allows the weights of results from individual models to vary over space and time. Demonstrated for Israel for the period 2004–2017, the proposed ensemble model outperformed each of the two base learners. It also attained excellent five-fold cross-validated performance, with overall root mean square error (RMSE) of 0.8 and 0.9 °C, mean absolute error (MAE) of 0.6 and 0.7 °C, and R2 of 0.95 and 0.98 in Stage 1 and Stage 2, respectively. The Stage 3 model for downscaling Ta residuals to 1 km MODIS grids achieved overall RMSE of 0.3 °C, MAE of 0.5 °C, and R2 of 0.63. The generated hourly 1 × 1 km2 Ta thus serves as a foundation for monitoring and assessing human health exposure to temperature extremes at a larger geographical scale, helping to further minimize exposure misclassification in epidemiological studies

Estimation of hourly near surface air temperature across Israel using an ensemble model

Mapping of near-surface air temperature (Ta) at high spatio-temporal resolution is essential for unbiased assessment of human health exposure to temperature extremes, not least given the observed trend of urbanization and global climate change. Data constraints have led previous studies to focus merely on daily Ta metrics, rather than hourly ones, making them insufficient for intra-day assessment of health exposure. In this study, we present a three-stage machine learning-based ensemble model to estimate hourly Ta at a high spatial resolution of 1 × 1 km2, incorporating remotely sensed surface skin temperature (Ts) from geostationary satellites, reanalysis synoptic variables, and observations from weather stations, as well as auxiliary geospatial variables, which account for spatio-temporal variability of Ta. The Stage 1 model gap-fills hourly Ts at 4 × 4 km2 from the Spinning Enhanced Visible and InfraRed Imager (SEVIRI), which are subsequently fed into the Stage 2 model to estimate hourly Ta at the same spatio-temporal resolution. The Stage 3 model downscales the residuals between estimated and measured Ta to a grid of 1 × 1 km2, taking into account additionally the monthly diurnal pattern of Ts derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) data. In each stage, the ensemble model synergizes estimates from the constituent base learners—random forest (RF) and extreme gradient boosting (XGBoost)—by applying a geographically weighted generalized additive model (GAM), which allows the weights of results from individual models to vary over space and time. Demonstrated for Israel for the period 2004–2017, the proposed ensemble model outperformed each of the two base learners. It also attained excellent five-fold cross-validated performance, with overall root mean square error (RMSE) of 0.8 and 0.9 °C, mean absolute error (MAE) of 0.6 and 0.7 °C, and R2 of 0.95 and 0.98 in Stage 1 and Stage 2, respectively. The Stage 3 model for downscaling Ta residuals to 1 km MODIS grids achieved overall RMSE of 0.3 °C, MAE of 0.5 °C, and R2 of 0.63. The generated hourly 1 × 1 km2 Ta thus serves as a foundation for monitoring and assessing human health exposure to temperature extremes at a larger geographical scale, helping to further minimize exposure misclassification in epidemiological studies

Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study

Background: Given the relationship between iron metabolism and lead toxicokinetics, we hypothesized that polymorphisms in iron metabolism genes might modify maternal-fetal lead transfer. The objective of this study was to determine whether maternal and/or infant transferrin (TF) and hemochromatosis (HFE) gene missense variants modify the association between maternal blood lead (MBL) and umbilical cord blood lead (UCBL). Methods: We studied 476 mother-infant pairs whose archived blood specimens were genotyped for TF P570S, HFE H63D and HFE C282Y. MBL and UCBL were collected within 12 hours of delivery. Linear regression models were used to examine the association between log-transformed MBL and UCBL, examine for confounding and collinearity, and explore gene-environment interactions. Results: The geometric mean MBL was 0.61 μg/dL (range 0.03, 3.2) and UCBL 0.42 (<0.02, 3.9). Gene variants were common with carrier frequencies ranging from 12-31%; all were in Hardy-Weinberg equilibrium. In an adjusted linear regression model, log MBL was associated with log UCBL (β = 0.92, 95% CI: 0.82, 1.03; p < 0.01) such that a 1% increase in MBL was associated with a 0.92% increase in UCBL among infants born to wild-type mothers. In infants born to C282Y variants, however, a 1% increase in MBL is predicted to increase UCBL 0.65% (βMain Effect = −0.002, 95% CI: −0.09, −0.09; p = 0.97; βInteraction = −0.27, 95% CI: −0.52, −0.01; p = 0.04), representing a 35% lower placental lead transfer among women with MBL 5 μg/dL. Conclusions: Maternal HFE C282Y gene variant status is associated with greater reductions in placental transfer of lead as MBL increases. The inclusion of gene-environment interaction in risk assessment models may improve efforts to safeguard vulnerable populations. Electronic supplementary material The online version of this article (doi:10.1186/1476-069X-13-77) contains supplementary material, which is available to authorized users

Perinatal Air Pollutant Exposures and Autism Spectrum Disorder in the Children of Nurses’ Health Study II Participants

Objective: Air pollution contains many toxicants known to affect neurological function and to have effects on the fetus in utero. Recent studies have reported associations between perinatal exposure to air pollutants and autism spectrum disorder (ASD) in children. We tested the hypothesis that perinatal exposure to air pollutants is associated with ASD, focusing on pollutants associated with ASD in prior studies. Methods: We estimated associations between U.S. Environmental Protection Agency–modeled levels of hazardous air pollutants at the time and place of birth and ASD in the children of participants in the Nurses’ Health Study II (325 cases, 22,101 controls). Our analyses focused on pollutants associated with ASD in prior research. We accounted for possible confounding and ascertainment bias by adjusting for family-level socioeconomic status (maternal grandparents’ education) and census tract–level socioeconomic measures (e.g., tract median income and percent college educated), as well as maternal age at birth and year of birth. We also examined possible differences in the relationship between ASD and pollutant exposures by child’s sex. Results: Perinatal exposures to the highest versus lowest quintile of diesel, lead, manganese, mercury, methylene chloride, and an overall measure of metals were significantly associated with ASD, with odds ratios ranging from 1.5 (for overall metals measure) to 2.0 (for diesel and mercury). In addition, linear trends were positive and statistically significant for these exposures (p < .05 for each). For most pollutants, associations were stronger for boys (279 cases) than for girls (46 cases) and significantly different according to sex. Conclusions: Perinatal exposure to air pollutants may increase risk for ASD. Additionally, future studies should consider sex-specific biological pathways connecting perinatal exposure to pollutants with ASD

A New Hybrid Spatio-temporal Model for Estimating Daily Multi-year PM2.5 Concentrations Across Northeastern USA Using High Resolution Aerosol Optical Depth Data

The use of satellite-based aerosol optical depth (AOD) to estimate fine particulate matter PM(sub 2.5) for epidemiology studies has increased substantially over the past few years. These recent studies often report moderate predictive power, which can generate downward bias in effect estimates. In addition, AOD measurements have only moderate spatial resolution, and have substantial missing data. We make use of recent advances in MODIS satellite data processing algorithms (Multi-Angle Implementation of Atmospheric Correction (MAIAC), which allow us to use 1 km (versus currently available 10 km) resolution AOD data.We developed and cross validated models to predict daily PM(sub 2.5) at a 1X 1 km resolution across the northeastern USA (New England, New York and New Jersey) for the years 2003-2011, allowing us to better differentiate daily and long term exposure between urban, suburban, and rural areas. Additionally, we developed an approach that allows us to generate daily high-resolution 200 m localized predictions representing deviations from the area 1 X 1 km grid predictions. We used mixed models regressing PM(sub 2.5) measurements against day-specific random intercepts, and fixed and random AOD and temperature slopes. We then use generalized additive mixed models with spatial smoothing to generate grid cell predictions when AOD was missing. Finally, to get 200 m localized predictions, we regressed the residuals from the final model for each monitor against the local spatial and temporal variables at each monitoring site. Our model performance was excellent (mean out-of-sample R(sup 2) = 0.88). The spatial and temporal components of the out-of-sample results also presented very good fits to the withheld data (R(sup 2) = 0.87, R(sup)2 = 0.87). In addition, our results revealed very little bias in the predicted concentrations (Slope of predictions versus withheld observations = 0.99). Our daily model results show high predictive accuracy at high spatial resolutions and will be useful in reconstructing exposure histories for epidemiological studies across this region

Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study

Background: Lead (Pb) exposure during pregnancy may increase the risk of adverse maternal, infant, or childhood health outcomes by interfering with hypothalamic-pituitary-adrenal-axis function. We examined relationships between maternal blood or bone Pb concentrations and features of diurnal cortisol profiles in 936 pregnant women from Mexico City. Methods: From 2007–11 we recruited women from hospitals/clinics affiliated with the Mexican Social Security System. Pb was measured in blood (BPb) during the second trimester and in mothers’ tibia and patella 1-month postpartum. We characterized maternal HPA-axis function using 10 timed salivary cortisol measurements collected over 2-days (mean: 19.7, range: 14–35 weeks gestation). We used linear mixed models to examine the relationship between Pb biomarkers and cortisol area under the curve (AUC), awakening response (CAR), and diurnal slope. Results: After adjustment for confounders, women in the highest quintile of BPb concentrations had a reduced CAR (Ratio: −13%; Confidence Interval [CI]: −24, 1, p-value for trend < 0.05) compared to women in the lowest quintile. Tibia/patella Pb concentrations were not associated with CAR, but diurnal cortisol slopes were suggestively flatter among women in the highest patella Pb quantile compared to women in the lowest quantile (Ratio: 14%; CI: −2, 33). BPb and bone Pb concentrations were not associated with cortisol AUC. Conclusions: Concurrent blood Pb levels were associated with cortisol awakening response in these pregnant women and this might explain adverse health outcomes associated with Pb. Further research is needed to confirm these results and determine if other environmental chemicals disrupt hypothalamic-pituitary-adrenal-axis function during pregnancy

Gestational Exposure to Endocrine-Disrupting Chemicals and Reciprocal Social, Repetitive, and Stereotypic Behaviors in 4- and 5-Year-Old Children: The HOME Study

Background: Endocrine-disrupting chemicals (EDCs) may be involved in the etiology of autism spectrum disorders, but identifying relevant chemicals within mixtures of EDCs is difficult. Objective: Our goal was to identify gestational EDC exposures associated with autistic behaviors. Methods: We measured the concentrations of 8 phthalate metabolites, bisphenol A, 25 polychlorinated biphenyls (PCBs), 6 organochlorine pesticides, 8 brominated flame retardants, and 4 perfluoroalkyl substances in blood or urine samples from 175 pregnant women in the HOME (Health Outcomes and Measures of the Environment) Study (Cincinnati, OH). When children were 4 and 5 years old, mothers completed the Social Responsiveness Scale (SRS), a measure of autistic behaviors. We examined confounder-adjusted associations between 52 EDCs and SRS scores using a two-stage hierarchical analysis to account for repeated measures and confounding by correlated EDCs. Results: Most of the EDCs were associated with negligible absolute differences in SRS scores (≤ 1.5). Each 2-SD increase in serum concentrations of polybrominated diphenyl ether-28 (PBDE-28) (β = 2.5; 95% CI: –0.6, 5.6) or trans-nonachlor (β = 4.1; 95% CI: 0.8–7.3) was associated with more autistic behaviors. In contrast, fewer autistic behaviors were observed among children born to women with detectable versus nondetectable concentrations of PCB-178 (β = –3.0; 95% CI: –6.3, 0.2), β-hexachlorocyclohexane (β = –3.3; 95% CI: –6.1, –0.5), or PBDE-85 (β = –3.2; 95% CI: –5.9, –0.5). Increasing perfluorooctanoate (PFOA) concentrations were also associated with fewer autistic behaviors (β = –2.0; 95% CI: –4.4, 0.4). Conclusions: Some EDCs were associated with autistic behaviors in this cohort, but our modest sample size precludes us from dismissing chemicals with null associations. PFOA, β-hexachlorocyclohexane, PCB-178, PBDE-28, PBDE-85, and trans-nonachlor deserve additional scrutiny as factors that may be associated with childhood autistic behaviors. Citation: Braun JM, Kalkbrenner AE, Just AC, Yolton K, Calafat AM, Sjödin A, Hauser R, Webster GM, Chen A, Lanphear BP. 2014. Gestational exposure to endocrine-disrupting chemicals and reciprocal social, repetitive, and stereotypic behaviors in 4- and 5-year-old children: the HOME Study. Environ Health Perspect 122:513–520; http://dx.doi.org/10.1289/ehp.130726

Asthma in Inner-City Children at 5–11 Years of Age and Prenatal Exposure to Phthalates: The Columbia Center for Children’s Environmental Health Cohort

Background: Studies suggest that phthalate exposures may adversely affect child respiratory health. Objectives: We evaluated associations between asthma diagnosed in children between 5 and 11 years of age and prenatal exposures to butylbenzyl phthalate (BBzP), di-n-butyl phthalate (DnBP), di(2-ethylhexyl) phthalate (DEHP), and diethyl phthalate (DEP). Methods: Phthalate metabolites were measured in spot urine collected from 300 pregnant inner-city women. Children were examined by an allergist or pulmonologist based on the first parental report of wheeze, other respiratory symptoms, and/or use of asthma rescue/controller medication in the preceding 12 months on repeat follow-up questionnaires. Standardized diagnostic criteria were used to classify these children as either having or not having current asthma at the time of the physician examination. Children without any report of wheeze or the other asthma-like symptoms were classified as nonasthmatics at the time of the last negative questionnaire. Modified Poisson regression analyses were used to estimate relative risks (RR) controlling for specific gravity and potential confounders. Results: Of 300 children, 154 (51%) were examined by a physician because of reports of wheeze, other asthma-like symptoms, and/or medication use; 94 were diagnosed with current asthma and 60 without current asthma. The remaining 146 children were classified as nonasthmatic. Compared with levels in nonasthmatics, prenatal metabolites of BBzP and DnBP were associated with a history of asthma-like symptoms (p 70% higher among children with maternal prenatal BBzP and DnBP metabolite concentrations in the third versus the first tertile. Conclusion: Prenatal exposure to BBzP and DnBP may increase the risk of asthma among inner-city children. However, because this is the first such finding, results require replication. Citation: Whyatt RM, Perzanowski MS, Just AC, Rundle AG, Donohue KM, Calafat AM, Hoepner LA, Perera FP, Miller RL. 2014. Asthma in inner-city children at 5–11 years of age and prenatal exposure to phthalates: the Columbia Center for Children’s Environmental Health Cohort. Environ Health Perspect 122:1141–1146; http://dx.doi.org/10.1289/ehp.130767