Cross cultural Web design: an experience of developing UK and Korean cultural markers

The international and multicultural nature of the World Wide Web positions the issues of recognizing and observing cultural differences at the forefront of considerations in the design of Web pages. We address some of these issues. Research has already identified some Web page design elements that may be culturally or genre specific, that may also be generalised as 'cultural markers', and that consequently influence Web page design and usability. These cultural markers represent a significant aspect of today's electronic environments in terms of influencing people's behaviour, changing their practices and attitudes, and affecting their learning and performance abilities. We identify general issues of cross-cultural Web page design by defining a check-list of design elements relevant for developing a Web site and investigate culturally specific design elements, on examples of South Korean and UK Web environments

Scalar field theory on kappa-Minkowski spacetime and translation and Lorentz invariance

We investigate the properties of kappa-Minkowski spacetime by using representations of the corresponding deformed algebra in terms of undeformed Heisenberg-Weyl algebra. The deformed algebra consists of kappa-Poincare algebra extended with the generators of the deformed Weyl algebra. The part of deformed algebra, generated by rotation, boost and momentum generators, is described by the Hopf algebra structure. The approach used in our considerations is completely Lorentz covariant. We further use an adventages of this approach to consistently construct a star product which has a property that under integration sign it can be replaced by a standard pointwise multiplication, a property that was since known to hold for Moyal, but not also for kappa-Minkowski spacetime. This star product also has generalized trace and cyclic properties and the construction alone is accomplished by considering a classical Dirac operator representation of deformed algebra and by requiring it to be hermitian. We find that the obtained star product is not translationally invariant, leading to a conclusion that the classical Dirac operator representation is the one where translation invariance cannot simultaneously be implemented along with hermiticity. However, due to the integral property satisfied by the star product, noncommutative free scalar field theory does not have a problem with translation symmetry breaking and can be shown to reduce to an ordinary free scalar field theory without nonlocal features and tachionic modes and basicaly of the very same form. The issue of Lorentz invariance of the theory is also discussed.Comment: 22 pages, no figures, revtex4, in new version comments regarding translation invariance and few references are added, accepted for publication in Int. J. Mod. Phys.

Kappa-deformed Snyder spacetime

We present Lie-algebraic deformations of Minkowski space with undeformed Poincare algebra. These deformations interpolate between Snyder and kappa-Minkowski space. We find realizations of noncommutative coordinates in terms of commutative coordinates and derivatives. Deformed Leibniz rule, the coproduct structure and star product are found. Special cases, particularly Snyder and kappa-Minkowski in Maggiore-type realizations are discussed. Our construction leads to a new class of deformed special relativity theories.Comment: 12 pages, no figures, LaTeX2e class file, accepted for publication in Modern Physics Letters

Evolution of Giant Planets in Eccentric Disks

We investigate the interaction between a giant planet and a viscous circumstellar disk by means of high-resolution, two-dimensional hydrodynamical simulations. We consider planet masses that range from 1 to 3 Jupiter masses (Mjup) and initial orbital eccentricities that range from 0 to 0.4. We find that a planet can cause eccentricity growth in a disk region adjacent to the planet's orbit, even if the planet's orbit is circular. Disk-planet interactions lead to growth in a planet's orbital eccentricity. The orbital eccentricities of a 2 Mjup and a 3 Mjup planet increase from 0 to 0.11 within about 3000 orbits. Over a similar time period, the orbital eccentricity of a 1 Mjup planet grows from 0 to 0.02. For a case of a 1 Mjup planet with an initial eccentricity of 0.01, the orbital eccentricity grows to 0.09 over 4000 orbits. Radial migration is directed inwards, but slows considerably as a planet's orbit becomes eccentric. If a planet's orbital eccentricity becomes sufficiently large, e > ~0.2, migration can reverse and so be directed outwards. The accretion rate towards a planet depends on both the disk and the planet orbital eccentricity and is pulsed over the orbital period. Planet mass growth rates increase with planet orbital eccentricity. For e~0.2 the mass growth rate of a planet increases by approximately 30% above the value for e=0. For e > ~0.1, most of the accretion within the planet's Roche lobe occurs when the planet is near the apocenter. Similar accretion modulation occurs for flow at the inner disk boundary which represents accretion toward the star.Comment: 20 pages 16 figures, 3 tables. To appear in The Astrophysical Journal vol.652 (December 1, 2006 issue

Proper Motions in Kapteyn Selected Area 103: A Preliminary Orbit for the Virgo Stellar Stream

We present absolute proper motions in Kapteyn Selected Area (SA) 103. This field is located 7 degrees west of the center of the Virgo Stellar Stream (VSS, Duffau et al. 2006), and has a well-defined main sequence representing the stream. In SA 103 we identify one RR Lyrae star as a member of the VSS according to its metallicity, radial velocity and distance. VSS candidate turnoff stars and subgiant stars have proper motions consistent with that of the RR Lyrae star. The 3D velocity data imply an orbit with a pericenter of 11 kpc and an apocenter of ~90 kpc. Thus, the VSS comprises tidal debris found near the pericenter of a highly destructive orbit. Examining the six globular clusters at distances larger than 50 kpc from the Galactic center, and the proposed orbit of the VSS, we find one tentative association, NGC 2419. We speculate that NGC 2419 is possibly the nucleus of a disrupted system of which the VSS is a part.Comment: ApJL accepte

The intellectual information system for management of geological and technical arrangements during oil field exploitation

The intellectual information system for management of geological and technical arrangements during oil fields exploitation is developed. Service-oriented architecture of its software is a distinctive feature of the system. The results of the cluster analysis of real field data received by means of this system are shown

Time course and management of key adverse events during the randomized phase III SOLAR-1 study of PI3K inhibitor alpelisib plus fulvestrant in patients with HR-positive advanced breast cancer.

Background Alpelisib (α-selective phosphatidylinositol 3-kinase inhibitor) plus fulvestrant is approved in multiple countries for men and postmenopausal women with PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer following progression on or after endocrine therapy. A detailed understanding of alpelisib's safety profile should inform adverse event (AE) management and enhance patient care. Patients and methods AEs in the phase III SOLAR-1 trial were assessed in patients with and without PIK3CA mutations. The impact of protocol-specified AE-management recommendations was evaluated, including an amendment to optimize hyperglycemia and rash management. Results Patients were randomly assigned to receive fulvestrant plus alpelisib (n = 284) or placebo (n = 287). The most common grade 3/4 AEs with alpelisib were hyperglycemia (grade 3, 32.7%; grade 4, 3.9%), rash (grade 3, 9.9%), and diarrhea (grade 3, 6.7%). Median time to onset of grade ≥3 toxicity was 15 days (hyperglycemia, based on fasting plasma glucose), 13 days (rash), and 139 days (diarrhea). Metformin alone or in combination with other antidiabetic agents was used by most patients (87.1%) with hyperglycemia. Preventive anti-rash medication resulted in lower incidence (any grade, 26.7% versus 64.1%) and severity of rash (grade 3, 11.6% versus 22.7%) versus no preventative medication. Discontinuations due to grade ≥3 AEs were lower following more-detailed AE management guidelines (7.9% versus 18.1% previously). Patients with PIK3CA mutations had a median alpelisib dose intensity of 248 mg/day. Median progression-free survival with alpelisib was 12.5 and 9.6 months for alpelisib dose intensities of ≥248 mg/day and Conclusions Hyperglycemia and rash occurred early during alpelisib treatment, while diarrhea occurred at a later time point. Early identification, prevention, and intervention, including concomitant medications and alpelisib dose modifications, resulted in less severe toxicities. Reductions in treatment discontinuations and improved progression-free survival at higher alpelisib dose intensities support the need for optimal AE management. ClinicalTrials.gov Id NCT02437318

Nuclei, Superheavy Nuclei and Hypermatter in a chiral SU(3)-Modell

A model based on chiral SU(3)-symmetry in nonlinear realisation is used for the investigation of nuclei, superheavy nuclei, hypernuclei and multistrange nuclear objects (so called MEMOs). The model works very well in the case of nuclei and hypernuclei with one Lambda-particle and rules out MEMOs. Basic observables which are known for nuclei and hypernuclei are reproduced satisfactorily. The model predicts Z=120 and N=172, 184 and 198 as the next shell closures in the region of superheavy nuclei. The calculations have been performed in self-consistent relativistic mean field approximation assuming spherical symmetry. The parameters were adapted to known nuclei.Comment: 19 pages, 11 figure